Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBCK2S)

• Drug Name: Sulfametopyrazine Drug Info
• Synonyms: Dalysep; Kelfizin; Kelfizina; Kelfizine; Longum; Polycidal; SMP; SULFALENE; Solfametopirazina; Sulfalen; Sulfaleno; Sulfalenum; Sulfamethopyrazine; Sulfamethoxypyrazine; Sulfamethoxysuccinate; Sulfametoxypyridazin; Sulfapyrazinemethoxine; Sulfapyrazinemethoxyine; Sulfapyrazinemethoxyne; Sulfapyrazinmethoxine; Sulphalene; Sulphametopyrazine; Kelfizine W; Solfametopirazina [DCIT]; AS 18908; CBMicro_013257; FI 5978; WR 4629; Farmitalia 204/122; Kelfizina (TN); Sulfalene (USAN); Sulfalene [USAN:INN]; Sulfaleno [INN-Spanish]; Sulfalenum [INN-Latin]; Sulfamethopyrazine (JAN); N1-(3-Methoxypyrazinyl)sulfanilamide; N(sup 1)-(3-Methoxypyrazinyl)sulfanilamide; N(sup1)-(3-Methoxypyrazinyl)sulfanilamide; N(sup 1)-(3-Methoxy-2-pyrazinyl)sulfanilamide; N(sup1)-(3-Methoxy-2-pyrazinyl)sulfanilamide; Sulfanilamide, N1-(3-methoxypyrazinyl)-(8CI); 2-(p-Aminobenzenesulfanamide)-3-methoxypyrazine; 2-(p-Aminobenzenesulfonamido)-3-methoxypyrazine; 2-Methoxy-3-sulfanilamidopyrazine; 2-Sulfanilamide 3-methoxy-pyrazine; 2-Sulfanilamido-3-methoxypyrazine; 3-Methoxy-2-sulfanilamidopyrazine; 3-Methoxy-2-sulfapyrazine; 3-Methoxypyrazine sulfanilamide; 4-Amino-N-(3-methoxy-pyrazin-2-yl)-benzenesulfonamide; 4-Amino-N-(3-methoxypyrazinyl)-benzenesulfonamide; 4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide; 4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Urinary tract infection	GC08	Withdrawn from market	[1]

• Therapeutic Class: Antiinfective Agents
• Cross-matching ID:
  PubChem CID: 9047
  ChEBI ID: CHEBI:32162
  CAS Number: CAS 152-47-6
  TTD Drug ID: DMBCK2S

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[3]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[4]
Doripenem	DM9UCJK	Cholecystitis		Approved	[5]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[6]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[7]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[8]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[9]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[10]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[5]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydropteroate synthetase (Bact folP)	TT4ILYC	DHPS_ECOLI	Inhibitor	[2]

References

• [1] Drug information of Sulfametopyrazine, 2008. eduDrugs.
• [2] Plasmodium falciparum dihydrofolate reductase Val-16 and Thr-108 mutation associated with in vivo resistance to antifolate drug: a case study. Indian J Malariol. 2001 Sep-Dec;38(3-4):76-83.
• [3] In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
• [4] Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
• [5] Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
• [6] Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.
• [7] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [8] Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
• [9] A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
• [10] Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.