Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBG534)

Drug Name

Org-25435 Drug Info

Synonyms

Org 25435; CHEMBL325728

Indication

Disease Entry	ICD 11	Status	REF
Epilepsy	8A60-8A68	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[3]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[4]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[5]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[3]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[6]
Thiamylal	DMHDF7B	Anaesthesia	9A78.6	Approved	[5]
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[4]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[5]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[5]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT01062867) First Administration to Man Of Org 25435 a New Intravenous Anesthetic. U.S. National Institutes of Health.
2	First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial. BMC Anesthesiol. 2010 Jun 29;10:10.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.