Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC5O3X)

Drug Name

FRG-8701 Drug Info

Synonyms

FRG8701; 108498-50-6; Acetamide,2-[(2-furanylmethyl)sulfinyl]-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-; Frg 8701; Frg-8701; ACMC-20mbjv; AC1L2WUW; SCHEMBL5083014; CTK4A6065; IWLUMUDDKHJJPB-UHFFFAOYSA-N; HY-U00238; AKOS030565773; N-(3-(3-(Piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide; CS-7405; L002080; N-{3-[3-(piperidinomethyl)phenoxy] propyl]-2-(furfurylsulfinyl) acetamide; Acetamide, 2-((2-furanylmethyl)sulfinyl)-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-

Indication

Disease Entry	ICD 11	Status	REF
Stomach ulcer	DA60.Z	Terminated	[1]

Cross-matching ID

PubChem CID: 130145
CAS Number: CAS 108498-50-6
TTD Drug ID: DMC5O3X

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Histamine H2 receptor (H2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[2]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[3]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[3]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[4]
Betazole	DMUFGAY	Gastric secretory disorder	DD90	Approved	[5]
Ebrotidine	DMV5KR3	Duodenal ulcer	DA63	Withdrawn from market	[6]
Pibutidine	DMXSTRM	Ulcerative colitis	DD71	Discontinued in Phase 3	[7]
Osutidine	DMN7TL8	Duodenal ulcer	DA63	Discontinued in Phase 3	[8]
KU-1257	DMZMFX6	Duodenal ulcer	DA63	Discontinued in Phase 3	[9]
Lavoltidine	DMTY5VE	Gastroesophageal reflux disease	DA22.Z	Discontinued in Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H2 receptor (H2R)	TTQHJ1K	HRH2_HUMAN	Modulator	[1]

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References

1	Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85.
2	Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
3	Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment. J Invest Dermatol. 2001 Feb;116(2):261-5.
4	Does the use of nizatidine, as a pro-kinetic agent, improve gastric emptying in patients post-oesophagectomy J Gastrointest Surg. 2009 Mar;13(3):432-7.
5	Effect of nizatidine and cimetidine on betazole-stimulated gastric secretion of normal subjects: comparison of effects on acid, water, and pepsin. Am J Gastroenterol. 1988 Jan;83(1):32-6.
6	Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.
7	Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 1995 Oct;48(4):774-82.
8	Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51(1):46-50.
9	Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea. Arzneimittelforschung. 1993 Feb;43(2):129-33.
10	New and Future Drug Development for Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2014 January; 20(1): 6-16.