Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCVO2Y)

• Drug Name: MLN-576 Drug Info
• Synonyms: XR-11576

Indication

Disease Entry	ICD 11	Status	REF
Acute lymphoblastic leukaemia	2A85	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 9886593
  TTD Drug ID: DMCVO2Y

Molecule-Related Drug Atlas

Drug(s) Targeting DNA topoisomerase I (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[2]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[2]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[3]
Belotecan hydrocholoride	DM3SRJZ	Small-cell lung cancer	2C25.Y	Approved	[4]
Topetecan	DMAE6LK	Small-cell lung cancer	2C25.Y	Approved	[5]
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[6]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
Exatecan	DMCA7FN	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
Edotecarin	DM3ZL7D	Gastric adenocarcinoma	2B72	Phase 3	[9]
Rubitecan	DMDWU1S	Human immunodeficiency virus infection	1C62	Phase 3	[10]

Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[2]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[12]
Idarubicin	DMM0XGL	Acute myelogenous leukaemia	2A41	Approved	[2]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[13]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[2]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[14]
Enoxacin	DMYTE6L	Acute gonococcal cervicitis		Approved	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[1]
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[1]

References

• [1] In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61.
• [4] Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009 Jul;109(7):3012-43.
• [5] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [6] Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol.2000 Mar;57(3):453-9.
• [7] Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.
• [8] Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks. Clin Cancer Res. 2001 Dec;7(12):3963-70.
• [9] Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36.
• [10] Rubitecan. Expert Opin Investig Drugs. 2006 Jan;15(1):71-9.
• [11] Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
• [12] Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
• [13] Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.
• [14] Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39.
• [15] Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121.