Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDBU7Q)

• Drug Name: D[Leu4,Lys8]VP Drug Info
• Synonyms: 42061-33-6; CHEMBL412972; d[Leu4,Lys8]-VP; d[Leu4,Lys8]VP; 1-Deamino-4-leu-8-lys-vasopressin; Vasopressin, 1-deamino-leu(4)-lys(8)-; Vasopressin, 1-deamino-leucyl(4)-lysine(8)-; BDBM50205309; AKOS024457446; (Deamino-Cys1,Leu4,Lys8)-Vasopressin; Vasopressin, 1-(3-mercaptopropanoic acid)-4-L-leucine-8-L-lysine-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44419030
  CAS Number: CAS 42061-33-6
  TTD Drug ID: DMDBU7Q

Molecule-Related Drug Atlas

Drug(s) Targeting Vasopressin V1b receptor (V1BR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[4]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[5]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[6]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[7]
ABT-436	DMNAU1V	Anxiety disorder	6B00-6B0Z	Phase 2	[8]
ARGENINE VASOPRESSIN	DM8KN0Q	Discovery agent	N.A.	Investigative	[2]
D[Arg4,Orn8]VP	DM8D4QT	Discovery agent	N.A.	Investigative	[2]
D[Arg4,Lys8]VP	DM69OVM	Discovery agent	N.A.	Investigative	[2]
D[Cha4,Lys8]VP	DM0GO7U	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Vasopressin V2 receptor (V2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[9]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[10]
Tolvaptan	DMIWFRL	Autosomal dominant polycystic kidney disease	GB81	Approved	[11]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[12]
Vasopressin	DMQ2FPC	Diabetes insipidus	5A61.5	Approved	[13]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[6]
Lixivaptan	DMDN4ZP	Hyponatraemia	5C72	Phase 3	[14]
Satavaptan	DME5PN3	Acute and chronic heart failure	BD1Z	Phase 3	[15]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[16]

Drug(s) Targeting Vasopressin V1a receptor (V1AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[17]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[18]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[12]
Felypressin	DMHLP9C	Localisation	N.A.	Approved	[19]
Terlipressin	DMT9FH3	Hypertension	BA00-BA04	Approved	[20]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[6]
Balovaptan	DMKMTDG	Autism spectrum disorder	6A02	Phase 3	[21]
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[22]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[16]

Drug(s) Targeting Oxytocin receptor (OTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[3]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[23]
Carbetocin	DMUSLW3	Postpartum haemorrhage	JA43	Approved	[19]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[24]
Retosiban	DMOYGZF	Preterm labour	JB00	Phase 3	[25]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[16]
Barusiban	DMWI0X3	Androgen deficiency	5A81.1	Phase 2	[26]
FE-202767	DMDGZ1C	Erectile dysfunction	HA01.1	Phase 2	[23]
GSK-557296	DM3ZL2O	Premature ejaculation	HA03.0Z	Phase 2	[27]
Pyrrolidine derivative 13	DM3VA8P	N. A.	N. A.	Patented	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxytocin receptor (OTR)	TTSCIUP	OXYR_HUMAN	Inhibitor	[2]
Vasopressin V1a receptor (V1AR)	TT4TFGN	V1AR_HUMAN	Inhibitor	[2]
Vasopressin V1b receptor (V1BR)	TTL9MHW	V1BR_HUMAN	Inhibitor	[2]
Vasopressin V2 receptor (V2R)	TTK8R02	V2R_HUMAN	Inhibitor	[2]

References

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• [15] Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. Biochem J. 2009 Apr 15;419(2):507-17.
• [16] Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6018-22.
• [17] Nonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene. Exp Clin Endocrinol Diabetes. 1999;107(3):157-65.
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• [19] Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473-512.
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• [21] Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder. J Med Chem. 2020 Feb 27;63(4):1511-1525.
• [22] Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92.
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• [24] Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9.
• [25] The Effect of an Oxytocin Receptor Antagonist (Retosiban, GSK221149A) on the Response of Human Myometrial Explants to Prolonged Mechanical Stretch.Endocrinology.2015 Oct;156(10):3511-6.
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