Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME3FUD)

Drug Name
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol Drug Info
Synonyms
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol; JPN; Triclosan derivative, 22; CHEMBL259880; BDBM25421; 6760-EP2316452A1; 6760-EP2311801A1; 6760-EP2311797A1; 6760-EP2311455A1; 6760-EP2301536A1; 6760-EP2298767A1; 6760-EP2281818A1; 6760-EP2311798A1; 6760-EP2308509A1; 6760-EP2305250A1; 6760-EP2301627A1; 6760-EP2301538A1; 6760-EP2298734A2; 6760-EP2295053A1; 6760-EP2292614A1; 6760-EP2287155A1; 6760-EP2277876A1; 6760-EP1441224A2; 6760-EP2314587A1; 6760-EP2311831A1; 6760-EP2311799A1; 6760-EP2308874A1; 6760-EP2308873A1; 6760-EP2305653A1
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16220126
TTD Drug ID
DME3FUD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [2]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [4]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [4]
MORIN DM2OGZ5 Discovery agent N.A. Investigative [5]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [5]
(-)-CATECHINGALLATE DMZOGSK Discovery agent N.A. Investigative [5]
Thiolactomycin DMBAWDG Malaria 1F40-1F45 Investigative [2]
GALLOCATECHIN GALLATE DMX2084 Discovery agent N.A. Investigative [5]
Diazaborines DM5UFZX Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasmodium Enoyl-ACP reductase (Malaria fabI) TTNX2CS Q965D5_PLAFA Inhibitor [1]

References

1 X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44.
2 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
3 Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
6 Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.