Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMET64R)

• Drug Name: Sucrose Octasulfate Drug Info
• Synonyms: SCHEMBL145070

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 444237
  CAS Number: CAS 57680-56-5
  TTD Drug ID: DMET64R

Molecule-Related Drug Atlas

Drug(s) Targeting Heparin-binding growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CVBT-141H	DMYPXQ2	Coronary artery disease	BA80	Phase 2	[3]
Riferminogene pecaplasmid	DMBKN4P	Critical limb ischemia	BD4Y	Discontinued in Phase 3	[4]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[1]
N,O6-Disulfo-Glucosamine	DMYCV7U	Discovery agent	N.A.	Investigative	[1]
O2-Sulfo-Glucuronic Acid	DME78MS	Discovery agent	N.A.	Investigative	[1]
Naphthalene Trisulfonate	DML6FI3	Discovery agent	N.A.	Investigative	[1]
5-AMINO-NAPHTALENE-2-MONOSULFONATE	DMYTUNE	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[10]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heparin-binding growth factor 1 (FGF1)	TTMY81X	FGF1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Fibroblast growth factor receptor 2 (FGFR2)	OTLOPACK	FGFR2_HUMAN	Protein Interaction/Cellular Processes	[2]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Molecular cloning, overexpression, and characterization of the ligand-binding D2 domain of fibroblast growth factor receptor. Biochem Biophys Res Commun. 2004 Apr 23;317(1):253-8. doi: 10.1016/j.bbrc.2004.03.028.
• [3] Clinical pipeline report, company report or official report of CVBT.
• [4] Riferminogene pecaplasmide. Am J Cardiovasc Drugs. 2010;10(5):343-6.
• [5] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [6] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [7] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [8] Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells. Biochem Biophys Res Commun. 1993 Feb 26;191(1):149-56. doi: 10.1006/bbrc.1993.1196.
• [9] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [10] Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
• [11] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [12] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [13] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.