General Information of Drug (ID: DMEZVGK)

Drug Name
DAU-5884 Drug Info
Synonyms 131780-47-7
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16759154
CAS Number
CAS 131780-47-7
TTD Drug ID
DMEZVGK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [2]
Fesoterodine fumarate DM13495 Overactive bladder GC50.0 Approved [3]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [4]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [5]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [6]
Oxyphenonium DMMQHOZ Visceral spasms MD81.4 Approved [7]
Benztropine DMGZOVN Parkinson disease 8A00.0 Approved [8]
Glycopyrrolate DM2M3ZA Anaesthesia 9A78.6 Approved [9]
Pirenzepine DMP6M1N Peptic ulcer DA61 Approved [10]
Cycrimine DM8C43Q Parkinson disease 8A00.0 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [12]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [2]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [13]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [14]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [15]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [16]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [4]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [17]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [18]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [19]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M1 (CHRM1) TTZ9SOR ACM1_HUMAN Modulator [1]
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Modulator [1]

References

1 Doi: 10.1038/bjp.2008.208
2 Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64.
5 Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460.
6 The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic dr... Psychopharmacology (Berl). 2009 Apr;203(2):295-301.
7 Ultraviolet spectroscopic estimation of microenvironments and bitter tastes of oxyphenonium bromide in cyclodextrin solutions. J Pharm Sci. 1999 Aug;88(8):759-62.
8 Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. Int J Pharm. 2008 Jun 5;357(1-2):55-60.
9 Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clin Pharmacol Ther. 2008 May;83(5):692-701.
10 Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31.
11 Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. J Chromatogr. 1989 Sep 29;494:135-42.
12 Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53.
13 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
14 Role of parasympathetic nerves and muscarinic receptors in allergy and asthma.Chem Immunol Allergy.2012;98:48-69.
15 M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor. Pharmacol Res. 2009 May;59(5):300-5.
16 Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am J Respir Cell Mol Biol. 2003 Feb;28(2):257-62.
17 Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout ... Eur J Pharmacol. 2009 Aug 1;615(1-3):201-6.
18 Interaction of neuromuscular blocking drugs with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Nov;125(5):1088-94.
19 Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor ... Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G112-G123.