Details of the Drug

General Information of Drug (ID: DMSHPW8)

• Drug Name: Tolterodine
• Synonyms: Tolterodina; Tolterodinum; Detrol (TN); Detrusitol (TN); Kabi-2234; 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol; 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol; 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol; 2-{(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl}-4-methylphenol

Indication

Disease Entry	ICD 11	Status	REF
Overactive bladder	GC50.0	Approved	[1]
Priapism	N.A.	Investigative	[2]

• Therapeutic Class: Antispasmodics
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 325.5
  Logarithm of the Partition Coefficient (xlogp); 5.6
  Rotatable Bond Count (rotbonds); 7
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 2
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
  Clearance: The drug present in the plasma can be removed from the body at the rate of 8.4 mL/min/kg [4]
  Elimination: 1% of drug is excreted from urine in the unchanged form [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 1.9 - 3.7 hours [4]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 24.57769 micromolar/kg/day [5]
  Unbound Fraction: The unbound fraction of drug in plasma is 0.037% [4]
  Vd: The volume of distribution (Vd) of drug is 113 +/- 26.7 L []
  Water Solubility: The ability of drug to dissolve in water is measured as 12 mg/mL [3]
• Chemical Identifiers:
  Formula: C22H31NO
  IUPAC Name: 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol
  Canonical SMILES: CC1=CC(=C(C=C1)O)[C@H](CCN(C(C)C)C(C)C)C2=CC=CC=C2
  InChI: InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1
  InChIKey: OOGJQPCLVADCPB-HXUWFJFHSA-N
• Cross-matching ID:
  PubChem CID: 443879
  ChEBI ID: CHEBI:9622
  CAS Number: 124937-51-5
  DrugBank ID: DB01036
  TTD ID: D0BZ7W
  INTEDE ID: DR1616
  ACDINA ID: D00183
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Antagonist	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[7]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[7]

Molecular Expression Atlas of This Drug

• The Studied Disease: Overactive bladder
• ICD Disease Classification: GC50.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M3 (CHRM3)	DTT	CHRM3	4.61E-07	-0.59	-0.73
Mephenytoin 4-hydroxylase (CYP2C19)	DME	CYP2C19	2.40E-01	-3.31E-02	-1.97E-01
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	7.30E-01	-1.91E-02	-1.41E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	1.90E-01	-9.81E-03	-5.96E-02
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	1.04E-02	6.29E-02	3.54E-01

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Tolterodine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Solifenacin	DMG592Q	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Solifenacin.	Functional bladder disorder [GC50]	[9]

Coadministration of a Drug Treating the Disease Different from Tolterodine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Arn-509	DMT81LZ	Moderate	Increased metabolism of Tolterodine caused by Arn-509 mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[10]
Oliceridine	DM6MDCF	Moderate	Additive CNS depression effects by the combination of Tolterodine and Oliceridine.	Acute pain [MG31]	[11]
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[12]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[12]
Memantine	DMD9WSC	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Memantine.	Alzheimer disease [8A20]	[9]
Dronedarone	DMA8FS5	Moderate	Decreased metabolism of Tolterodine caused by Dronedarone mediated inhibition of CYP450 enzyme.	Angina pectoris [BA40]	[13]
Nifedipine	DMSVOZT	Moderate	Decreased metabolism of Tolterodine caused by Nifedipine mediated inhibition of CYP450 enzyme.	Angina pectoris [BA40]	[13]
Posaconazole	DMUL5EW	Moderate	Decreased metabolism of Tolterodine caused by Posaconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[13]
Desipramine	DMT2FDC	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Desipramine.	Attention deficit hyperactivity disorder [6A05]	[9]
Dalfopristin	DM4LTKV	Moderate	Decreased metabolism of Tolterodine caused by Dalfopristin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[13]
Clarithromycin	DM4M1SG	Moderate	Decreased metabolism of Tolterodine caused by Clarithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[13]
Troleandomycin	DMUZNIG	Moderate	Decreased metabolism of Tolterodine caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[13]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Cariprazine.	Bipolar disorder [6A60]	[9]
Lapatinib	DM3BH1Y	Moderate	Decreased metabolism of Tolterodine caused by Lapatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Tucatinib	DMBESUA	Moderate	Decreased metabolism of Tolterodine caused by Tucatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Acetylcholine	DMDF79Z	Moderate	Antagonize the effect of Tolterodine when combined with Acetylcholine.	Cataract [9B10]	[14]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[15]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[15]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[15]
Dihydrocodeine	DMB0FWL	Moderate	Additive CNS depression effects by the combination of Tolterodine and Dihydrocodeine.	Chronic pain [MG30]	[16]
Arbutamine	DMCY8AF	Moderate	Increased risk of rapid heart rate by the combination of Tolterodine and Arbutamine.	Coronary atherosclerosis [BA80]	[17]
Osilodrostat	DMIJC9X	Moderate	Decreased metabolism of Tolterodine caused by Osilodrostat mediated inhibition of CYP450 enzyme.	Cushing syndrome [5A70]	[13]
Ivacaftor	DMZC1HS	Moderate	Decreased metabolism of Tolterodine caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[13]
MK-8228	DMOB58Q	Moderate	Decreased metabolism of Tolterodine caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[13]
Sertraline	DM0FB1J	Minor	Decreased metabolism of Tolterodine caused by Sertraline mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[18]
Nefazodone	DM4ZS8M	Moderate	Decreased metabolism of Tolterodine caused by Nefazodone mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[13]
Escitalopram	DMFK9HG	Minor	Decreased metabolism of Tolterodine caused by Escitalopram mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[18]
OPC-34712	DMHG57U	Moderate	Additive anticholinergic effects by the combination of Tolterodine and OPC-34712.	Depression [6A70-6A7Z]	[9]
Clomipramine	DMINRKW	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Clomipramine.	Depression [6A70-6A7Z]	[9]
Doxepin	DMPI98T	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Doxepin.	Depression [6A70-6A7Z]	[9]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Mepenzolate.	Digestive system disease [DE2Z]	[9]
Oxybutynine	DMJPBAX	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Oxybutynine.	Discovery agent [N.A.]	[9]
Cenobamate	DM8KLU9	Moderate	Increased metabolism of Tolterodine caused by Cenobamate mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[19]
Stiripentol	DMMSDOY	Moderate	Decreased metabolism of Tolterodine caused by Stiripentol mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[13]
Rufinamide	DMWE60C	Moderate	Increased metabolism of Tolterodine caused by Rufinamide mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[10]
Diphenhydramine	DMKQTBA	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Diphenhydramine.	Episodic vestibular syndrome [AB31]	[9]
Nadolol	DMW6GVL	Moderate	Additive CNS depression effects by the combination of Tolterodine and Nadolol.	Essential hypertension [BA00]	[10]
Itraconazole	DMCR1MV	Moderate	Decreased metabolism of Tolterodine caused by Itraconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[13]
Miconazole	DMPMYE8	Moderate	Decreased metabolism of Tolterodine caused by Miconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[13]
Pilocarpine	DMV9ADG	Moderate	Antagonize the effect of Tolterodine when combined with Pilocarpine.	Glaucoma [9C61]	[20]
Carvedilol	DMHTEAO	Moderate	Antagonize the effect of Tolterodine when combined with Carvedilol.	Heart failure [BD10-BD1Z]	[10]
Boceprevir	DMBSHMF	Moderate	Decreased metabolism of Tolterodine caused by Boceprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[13]
Telaprevir	DMMRV29	Moderate	Decreased metabolism of Tolterodine caused by Telaprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[13]
Rifapentine	DMCHV4I	Moderate	Increased metabolism of Tolterodine caused by Rifapentine mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[21]
Fosamprenavir	DM4W9B3	Moderate	Decreased metabolism of Tolterodine caused by Fosamprenavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[13]
Cobicistat	DM6L4H2	Moderate	Decreased metabolism of Tolterodine caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[13]
Saquinavir	DMG814N	Moderate	Decreased metabolism of Tolterodine caused by Saquinavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[13]
Etravirine	DMGV8QU	Moderate	Increased metabolism of Tolterodine caused by Etravirine mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[22]
Darunavir	DMN3GCH	Moderate	Decreased metabolism of Tolterodine caused by Darunavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[13]
Atazanavir	DMSYRBX	Moderate	Decreased metabolism of Tolterodine caused by Atazanavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[13]
Acebutolol	DM0TI4U	Moderate	Antagonize the effect of Tolterodine when combined with Acebutolol.	Hypertension [BA00-BA04]	[10]
Penbutolol	DM4ES8F	Moderate	Additive CNS depression effects by the combination of Tolterodine and Penbutolol.	Hypertension [BA00-BA04]	[10]
Nebivolol	DM7F1PA	Moderate	Antagonize the effect of Tolterodine when combined with Nebivolol.	Hypertension [BA00-BA04]	[10]
Givosiran	DM5PFIJ	Minor	Decreased metabolism of Tolterodine caused by Givosiran mediated inhibition of CYP450 enzyme.	Inborn porphyrin/heme metabolism error [5C58]	[18]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[9]
Berotralstat	DMWA2DZ	Moderate	Decreased metabolism of Tolterodine caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[23]
ITI-007	DMUQ1DO	Moderate	Additive anticholinergic effects by the combination of Tolterodine and ITI-007.	Insomnia [7A00-7A0Z]	[9]
R0-93877	DMM4U9G	Moderate	Antagonize the effect of Tolterodine when combined with R0-93877.	Irritable bowel syndrome [DD91]	[24]
Glycerol phenylbutyrate	DMDGRQO	Minor	Decreased metabolism of Tolterodine caused by Glycerol phenylbutyrate mediated inhibition of CYP450 enzyme.	Liver disease [DB90-DB9Z]	[18]
Crizotinib	DM4F29C	Moderate	Decreased metabolism of Tolterodine caused by Crizotinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[13]
Brigatinib	DM7W94S	Moderate	Increased metabolism of Tolterodine caused by Brigatinib mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[25]
Ceritinib	DMB920Z	Moderate	Decreased metabolism of Tolterodine caused by Ceritinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[13]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Tolterodine caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[26]
Dacomitinib	DMOH8VY	Minor	Decreased metabolism of Tolterodine caused by Dacomitinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[18]
Selpercatinib	DMZR15V	Moderate	Decreased metabolism of Tolterodine caused by Selpercatinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[13]
Lumefantrine	DM29GAD	Minor	Decreased metabolism of Tolterodine caused by Lumefantrine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[18]
Halofantrine	DMOMK1V	Minor	Decreased metabolism of Tolterodine caused by Halofantrine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[18]
Hydroxychloroquine	DMSIVND	Minor	Decreased metabolism of Tolterodine caused by Hydroxychloroquine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[18]
Primaquine	DMWQ16I	Minor	Decreased metabolism of Tolterodine caused by Primaquine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[18]
Idelalisib	DM602WT	Moderate	Decreased metabolism of Tolterodine caused by Idelalisib mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[13]
IPI-145	DMWA24P	Moderate	Decreased metabolism of Tolterodine caused by IPI-145 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[13]
Vemurafenib	DM62UG5	Minor	Decreased metabolism of Tolterodine caused by Vemurafenib mediated inhibition of CYP450 enzyme.	Melanoma [2C30]	[18]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Tolterodine caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[10]
Danazol	DML8KTN	Moderate	Decreased metabolism of Tolterodine caused by Danazol mediated inhibition of CYP450 enzyme.	Menstrual cycle bleeding disorder [GA20]	[13]
Exjade	DMHPRWG	Moderate	Decreased metabolism of Tolterodine caused by Exjade mediated inhibition of CYP450 enzyme.	Mineral absorption/transport disorder [5C64]	[27]
Panobinostat	DM58WKG	Minor	Decreased metabolism of Tolterodine caused by Panobinostat mediated inhibition of CYP450 enzyme.	Multiple myeloma [2A83]	[18]
Neostigmine	DM6T2J3	Moderate	Antagonize the effect of Tolterodine when combined with Neostigmine.	Myasthenia gravis [8C6Y]	[28]
Ambenonium	DMOP0BL	Moderate	Antagonize the effect of Tolterodine when combined with Ambenonium.	Myasthenia gravis [8C6Y]	[28]
Nilotinib	DM7HXWT	Moderate	Decreased metabolism of Tolterodine caused by Nilotinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[29]
Phenindamine	DMDTC7R	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Phenindamine.	Nasopharyngitis [CA00]	[9]
Promethazine	DM6I5GR	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Promethazine.	Nausea/vomiting [MD90]	[9]
Rolapitant	DM8XP26	Minor	Decreased metabolism of Tolterodine caused by Rolapitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[18]
Cyclizine	DM9G7BS	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Cyclizine.	Nausea/vomiting [MD90]	[9]
Netupitant	DMEKAYI	Moderate	Decreased metabolism of Tolterodine caused by Netupitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[13]
Metoclopramide	DMFA5MY	Moderate	Antagonize the effect of Tolterodine when combined with Metoclopramide.	Nausea/vomiting [MD90]	[30]
Bupropion	DM5PCS7	Minor	Decreased metabolism of Tolterodine caused by Bupropion mediated inhibition of CYP450 enzyme.	Nicotine use disorder [6C4A]	[18]
Entrectinib	DMMPTLH	Moderate	Decreased metabolism of Tolterodine caused by Entrectinib mediated inhibition of CYP450 enzyme.	Non-small cell lung cancer [2C25]	[13]
Lorcaserin	DMG6OYJ	Minor	Decreased metabolism of Tolterodine caused by Lorcaserin mediated inhibition of CYP450 enzyme.	Obesity [5B80-5B81]	[18]
Dexfenfluramine	DMJ7YDS	Minor	Decreased metabolism of Tolterodine caused by Dexfenfluramine mediated inhibition of CYP450 enzyme.	Obesity [5B80-5B81]	[18]
Polythiazide	DMCH80F	Minor	Altered absorption of Tolterodine due to GI dynamics variation caused by Polythiazide.	Oedema [MG29]	[31]
Levomethadyl Acetate	DM06HG5	Moderate	Additive CNS depression effects by the combination of Tolterodine and Levomethadyl Acetate.	Opioid use disorder [6C43]	[16]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Tolterodine caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[13]
Oxymorphone	DM65AGJ	Moderate	Additive CNS depression effects by the combination of Tolterodine and Oxymorphone.	Pain [MG30-MG3Z]	[11]
Dezocine	DMJDB0Y	Moderate	Additive CNS depression effects by the combination of Tolterodine and Dezocine.	Pain [MG30-MG3Z]	[11]
Flavoxate	DMKV4NL	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Flavoxate.	Pain [MG30-MG3Z]	[9]
Levodopa	DMN3E57	Moderate	Altered absorption of Tolterodine due to GI dynamics variation caused by Levodopa.	Parkinsonism [8A00]	[32]
Orphenadrine	DMW542E	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Orphenadrine.	Parkinsonism [8A00]	[9]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Tolterodine caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[33]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Methylscopolamine.	Peptic ulcer [DA61]	[9]
Lefamulin	DME6G97	Moderate	Decreased metabolism of Tolterodine caused by Lefamulin mediated inhibition of CYP450 enzyme.	Pneumonia [CA40]	[34]
Lonafarnib	DMGM2Z6	Moderate	Decreased metabolism of Tolterodine caused by Lonafarnib mediated inhibition of CYP450 enzyme.	Premature ageing appearance [LD2B]	[13]
ABIRATERONE	DM8V75C	Minor	Decreased metabolism of Tolterodine caused by ABIRATERONE mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[18]
Enzalutamide	DMGL19D	Moderate	Increased metabolism of Tolterodine caused by Enzalutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[35]
Bicalutamide	DMZMSPF	Moderate	Decreased metabolism of Tolterodine caused by Bicalutamide mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[13]
Levomepromazine	DMIKFEL	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Levomepromazine.	Psychotic disorder [6A20-6A25]	[9]
Temsirolimus	DMS104F	Moderate	Increased plasma concentrations of Tolterodine and Temsirolimus due to competitive inhibition of the same metabolic pathway.	Renal cell carcinoma [2C90]	[36]
Oxamniquine	DM2QDX1	Minor	Decreased metabolism of Tolterodine caused by Oxamniquine mediated inhibition of CYP450 enzyme.	Schistosomiasis [1F86]	[18]
Quetiapine	DM1N62C	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Quetiapine.	Schizophrenia [6A20]	[9]
Aripiprazole	DM3NUMH	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Aripiprazole.	Schizophrenia [6A20]	[9]
Iloperidone	DM6AUFY	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Iloperidone.	Schizophrenia [6A20]	[9]
Paliperidone	DM7NPJS	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Paliperidone.	Schizophrenia [6A20]	[9]
Molindone	DMAH70G	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Molindone.	Schizophrenia [6A20]	[9]
Thiothixene	DMDINC4	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Thiothixene.	Schizophrenia [6A20]	[9]
Asenapine	DMSQZE2	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Asenapine.	Schizophrenia [6A20]	[9]
Pimozide	DMW83TP	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Pimozide.	Schizophrenia [6A20]	[9]
Voxelotor	DMCS6M5	Moderate	Decreased metabolism of Tolterodine caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[13]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Tolterodine caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[10]
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Tolterodine caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Armodafinil	DMGB035	Minor	Increased metabolism of Tolterodine caused by Armodafinil mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[37]
LEE011	DMMX75K	Moderate	Decreased metabolism of Tolterodine caused by LEE011 mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Pitolisant	DM8RFNJ	Moderate	Increased metabolism of Tolterodine caused by Pitolisant mediated induction of CYP450 enzyme.	Somnolence [MG42]	[10]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Tolterodine caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[38]
Chlorpheniramine	DM5URA2	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Chlorpheniramine.	Vasomotor/allergic rhinitis [CA08]	[9]
Trimeprazine	DMEMV9D	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[12]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Tolterodine and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[9]
Propafenone	DMPIBJK	Minor	Decreased metabolism of Tolterodine caused by Propafenone mediated inhibition of CYP450 enzyme.	Ventricular tachyarrhythmia [BC71]	[18]
Amiodarone	DMUTEX3	Moderate	Decreased metabolism of Tolterodine caused by Amiodarone mediated inhibition of CYP450 enzyme.	Ventricular tachyarrhythmia [BC71]	[13]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Ethyl acrylate	E00191	8821	Film/membrane-forming agent; Flavoring agent
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Isopropyl alcohol	E00070	3776	Antimicrobial preservative; Solvent
Oleic acid	E00421	445639	Emulsifying agent; Penetration agent; Solubilizing agent
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sodium stearyl fumarate	E00545	23665634	lubricant
Stearic acid	E00079	5281	Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Ammonia	E00007	222	Alkalizing agent
Brushite	E00392	104805	Diluent
Butyl alcohol	E00011	263	Flavoring agent; Solvent
Calcium hydrogenphosphate	E00294	24441	Diluent
Carmellose sodium	E00625	Not Available	Disintegrant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Hypromellose	E00634	Not Available	Coating agent
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Medium-chain triglyceride	E00640	Not Available	Emollient; Lubricant; Surfactant
Methyl methacrylate	E00133	6658	Film/membrane-forming agent
Polyethylene glycol 6000	E00655	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Potassium hydroxide	E00233	14797	Alkalizing agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Saccharose	E00091	5988	Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Triacetin	E00080	5541	Humectant; Plasticizing agent; Solvent
Triethyl citrate	E00128	6506	Plasticizing agent; Solvent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Tolterodine 2 mg capsule	2 mg	24 HR Extended Release Oral Capsule	Oral
Tolterodine 4 mg capsule	4 mg	24 HR Extended Release Oral Capsule	Oral
Tolterodine 1 mg tablet	1 mg	Oral Tablet	Oral
Tolterodine 2 mg tablet	2 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

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