Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFEGB0)

Drug Name

Segesterone acetate; ethinyl estradiol Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Contraception	QA21	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[2]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[3]
Ulipristal	DMBNI20	Contraception	QA21	Approved	[4]
Etonogestrel	DMKA8J4	Contraception	QA21	Approved	[5]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[6]
Norgestimate	DMYP4XC	Acne vulgaris	ED80	Approved	[5]
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[7]
Medroxyprogesterone	DMBGWPH	Solid tumour/cancer	2A00-2F9Z	Approved	[7]
Ethynodiol Diacetate	DMZM84R	Contraception	QA21	Approved	[8]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[9]
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Drug(s) Targeting G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[10]
G15	DMMEC9D	Discovery agent	N.A.	Investigative	[11]
G36	DMDJCIP	Discovery agent	N.A.	Investigative	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled estrogen receptor 1 (GPER1)	TTDSB34	GPER1_HUMAN	Modulator	[1]
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Modulator	[1]

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References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	Clinical pipeline report, company report or official report of lipocine.
3	Preclinical experience with two selective progesterone receptor modulators on breast and endometrium. Steroids. 2000 Oct-Nov;65(10-11):733-40.
4	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5	Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7.
6	Focus on anastrozole and breast cancer. Curr Med Res Opin. 2003;19(8):683-8.
7	Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharm... Steroids. 2008 Feb;73(2):222-31.
8	Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus. Endocrinology. 1977 Jun;100(6):1579-84.
9	Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins. Mol Pharmacol. 2009 Jun;75(6):1317-24.
10	Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol. 2006 Apr;2(4):207-12.
11	In vivo effects of a GPR30 antagonist. Nat Chem Biol. 2009 Jun;5(6):421-7.
12	Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66.