Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFHTBX)

• Drug Name: L-threonine Drug Info
• Synonyms: L-threonine; threonine; 72-19-5; H-Thr-OH; Threonin; L-(-)-Threonine; (2S,3R)-2-amino-3-hydroxybutanoic acid; (S)-Threonine; 2-amino-3-hydroxybutyric acid; H-DL-Thr-OH; Threonine (VAN); Treonina [Spanish]; Threoninum [Latin]; Threonine [USAN:INN]; Threonine, L-; (2S,3R)-2-Amino-3-hydroxybutyric acid; thre; L-Threonin; L-thr; (2S)-threonine; L-alpha-Amino-beta-hydroxybutyric acid; (2S,3R)-(-)-Threonine; 2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))-; UNII-2ZD004190S; Butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6288
  ChEBI ID: CHEBI:16857
  CAS Number: CAS 72-19-5
  TTD Drug ID: DMFHTBX
  VARIDT Drug ID: DR00244

Molecule-Related Drug Atlas

Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[3]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[3]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[4]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[5]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[6]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[7]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[8]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[9]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[2]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)	DTW7AE3	AAAT_HUMAN	Substrate	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4785).
• [2] D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.
• [3] Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64.
• [4] A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochem Biophys Res Commun. 2008 Nov 14;376(2):267-70.
• [5] Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53.
• [6] High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5.
• [7] Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.
• [8] Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10.
• [9] Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005 Apr 25;579(11):2499-506.