Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFK8Y9)

• Drug Name: Dehydrocholic acid Drug Info
• Synonyms: Sodium dehydrocholate; 145-41-5; DEHYDROCHOLATE SODIUM; Dehydrocholate (sodium); Biliron; Carachol; Dehydrocholic acid sodium salt; UNII-W4193719XR; Suprachol; Biliton; Dycholium; Dilabil sodium; Decholin Sodium; Decholin sodium salt; W4193719XR; Natriumdehydrocholat [German]; Dehydrocholic acid, sodium salt; Sodium 3,7,12-triketocholanate; Natrii dehydrocholas [INN-Latin]; Dehidrocolato sodico [INN-Spanish]; EINECS 205-652-1; 81-23-2 (Parent); Dehydrocholate de sodium [INN-French]; Natriumdehydrocholat; Sodium 3,7,12-trioxo-5-bet

Indication

Disease Entry	ICD 11	Status	REF
Constipation	DD91.1	Approved	[1]

• Cross-matching ID:
  PubChem CID: 6674
  ChEBI ID: CHEBI:31459
  CAS Number: CAS 81-23-2
  TTD Drug ID: DMFK8Y9

Molecule-Related Drug Atlas

Drug(s) Metabolized By Beta-hydroxysteroid dehydrogenase (hdhB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[2]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[3]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[8]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-hydroxysteroid dehydrogenase (hdhB) Main DME	DEOMLHG	A4ECA9_9ACTN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Dehydrogenase/reductase SDR family member 11 (DHRS11)	OTU3J0ZL	DHR11_HUMAN	Biotransformations	[3]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35.
• [3] Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chem Biol Interact. 2019 May 25;305:12-20. doi: 10.1016/j.cbi.2019.03.026. Epub 2019 Mar 26.
• [4] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [5] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [6] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [7] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [8] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [9] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [10] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.