Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGKSVF)

• Drug Name: carbocyclic thromboxane A2 Drug Info
• Synonyms: 9alpha,11alpha,11a-dicarba-TXA2; CTA-2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5311387
  CAS Number: CAS 74034-56-3
  TTD Drug ID: DMGKSVF

Molecule-Related Drug Atlas

Drug(s) Targeting Thromboxane A2 receptor (TBXA2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[4]
Ridogrel	DMWH9CN	Acute myocardial infarction	BA41	Approved	[5]
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[6]
Ramatroban	DMB8UQ3	Perennial allergic rhinitis	CA08.03	Phase 2/3	[7]
KP-496	DMCO8UZ	Asthma	CA23	Phase 2	[8]
FK-070	DMJSD5W	Angina pectoris	BA40	Phase 2	[9]
TAK-128	DMHPEFS	Diabetic neuropathy	8C0Z	Phase 2	[10]
Ifetroban sodium	DMZP84Y	Thrombosis	DB61-GB90	Phase 2	[11]
Ifetroban	DMEV39E	Aspirin-induced asthma	CA23.20	Phase 2	[12]
YM-57158	DMS31YW	Allergic rhinitis	CA08.0	Phase 1	[13]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[15]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[23]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thromboxane A2 receptor (TBXA2R)	TT2O84V	TA2R_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Tumor necrosis factor ligand superfamily member 11 (TNFSF11)	OTJEPKEQ	TNF11_HUMAN	Gene/Protein Processing	[3]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Gene/Protein Processing	[3]

References

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• [27] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [28] 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):381-8. doi: 10.1016/j.jsbmb.2006.12.054. Epub 2007 Feb 12.
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• [30] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.