Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGOXPQ)

• Drug Name: DP-VPA Drug Info
• Synonyms: TVA; RAP-valproate; SPD-421; Valproic acid prodrug, Shire; RAP-valproate, D-Pharm

Indication

Disease Entry	ICD 11	Status	REF
Bipolar disorder	6A60	Approved	[1]

• Cross-matching ID: TTD Drug ID: DMGOXPQ

Molecule-Related Drug Atlas

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Seizure disorder	8A6Z	Approved	[3]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	Approved	[4]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[5]
Clonazepam	DMTO13J	Epilepsy	8A60-8A68	Approved	[6]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[7]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[8]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[9]
Androsterone	DMITJAK	N. A.	N. A.	Phase 3	[4]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[10]
Phentermine+topiramate	DMVEHM4	Obesity	5B81	Phase 3	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008928)
• [2] DP-VPA D-Pharm. Curr Opin Investig Drugs. 2002 Jun;3(6):921-3.
• [3] DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
• [4] Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605.
• [5] 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7.
• [6] Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
• [7] Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action. Int J Antimicrob Agents. 2003 Sep;22(3):318-31.
• [8] Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new se... J Med Chem. 1997 Sep 12;40(19):3109-18.
• [9] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [10] Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9.
• [11] Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.