Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHZV7X)

• Drug Name: Golimumab Drug Info
• Synonyms: Simponi (TN); Golimumab (USAN/INN)

Indication

Disease Entry	ICD 11	Status	REF
Psoriatic arthritis	FA21	Approved	[1]
Rheumatoid arthritis	FA20	Approved	[2]
Ulcerative colitis	DD71	Approved	[3]
Inflammatory bowel disease	DD72	Phase 2/3	[4]

• Cross-matching ID: TTD Drug ID: DMHZV7X

Molecule-Related Drug Atlas

Drug(s) Targeting Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[6]
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[7]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[8]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[9]
Enbrel	DM7RNP3	Arthritis	FA20	Approved	[10]
Certolizumab	DM5CL9Z	Rheumatoid arthritis	FA20	Approved	[11]
Etanercept	DMCV109	Arthritis	FA20	Approved	[12]
Adalimumab	DMQMV1B	Crohn disease	DD70	Approved	[13]
Infliximab	DMH7OIA	Crohn disease	DD70	Approved	[14]
Golnerminogene pradenovac	DMKWV4B	Esophageal cancer	2B70	Phase 3	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Not Available	[5]

References

• [1] Efficacy and safety of biologics in psoriatic arthritis: a systematic literature review and network meta-analysis. RMD Open. 2020 Feb;6(1):e001117.
• [2] ClinicalTrials.gov (NCT02390700) Observational Study of Golimumab Intravenous Infusion
• [3] Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol. 2022 Feb;7(2):161-170.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6776).
• [5] Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
• [6] Efficacy of different thalidomide regimens for patients with multiple myeloma and its relationship with TNF-alpha level. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1312-5.
• [7] Clinical pipeline report, company report or official report of AstraZeneca (2009).
• [8] Targeted therapies in myelodysplastic syndromes: ASH 2003 review. Semin Hematol. 2004 Apr;41(2 Suppl 4):13-20.
• [9] Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351.
• [10] Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loose... J Bone Joint Surg Am. 2001 Jul;83(7):1057-61.
• [11] Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
• [12] The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.
• [13] Adalimumab for psoriasis patients who are non-responders to etanercept: open-label prospective evaluation. J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1394-7.
• [14] Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2008 Jun;4(6):300-9.
• [15] TNFerade, an adenovector carrying the transgene for human tumor necrosis factor alpha, for patients with advanced solid tumors: surgical experience... Ann Surg Oncol. 2005 Oct;12(10):825-30.