General Information of Drug (ID: DMI4OTW)

Drug Name
ALFAXALONE Drug Info
Synonyms
Alphaxalone; Alfaxalone; 23930-19-0; 5alpha-Pregnan-3alpha-ol-11,20-dione; GR 2/234; Alfaxalonum [INN-Latin]; Alfaxalona [INN-Spanish]; 3alpha-Hydroxy-5alpha-pregnane-11,20-dione; UNII-BD07M97B2A; BRN 3217240; MLS001076262; MLS000069684; 3alpha-Hydroxy-5alpha-pregnan-11,20-dion; BD07M97B2A; CHEMBL190279; CHEBI:34531; 3-alpha-Hydroxy-5-alpha-pregnane-11,20-dione; (3-alpha,5-alpha)-3-Hydroxypregnane-11,20-dione; alfaxolone; 3-Hydroxypregnane-11,20-dione; NCGC00023100-03; SMR000058494; (3a,5a)-3-Hydroxypregnane-11,20-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
104845
ChEBI ID
CHEBI:34531
CAS Number
CAS 23930-19-0
TTD Drug ID
DMI4OTW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [3]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [4]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [5]
Clonazepam DMTO13J Absence epilepsy Approved [6]
Piperazine DMTY9LU Ascariasis 1F62 Approved [7]
Alpidem DMN7Y9K Anxiety disorder 6B00-6B0Z Approved [8]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [9]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [10]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [4]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5461).
2 Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54.
3 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
4 Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605.
5 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7.
6 Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
7 Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action. Int J Antimicrob Agents. 2003 Sep;22(3):318-31.
8 Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new se... J Med Chem. 1997 Sep 12;40(19):3109-18.
9 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
10 DP-VPA D-Pharm. Curr Opin Investig Drugs. 2002 Jun;3(6):921-3.
11 Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9.