General Information of Drug (ID: DMJ38YV)

Drug Name
QEDIIRNIARHLAQVGDSMDR Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
77280325
TTD Drug ID
DMJ38YV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
AZD5991 DM7QGHO Haematological malignancy 2B33.Y Phase 1 [3]
AMG 176 DM0Q7NO Acute myeloid leukaemia 2A60 Phase 1 [3]
PRT1419 DMIKE0O Melanoma 2C30 Phase 1 [4]
ABBV-467 DM87SM9 Multiple myeloma 2A83 Phase 1 [5]
MIK665 DMTUVCG Acute myeloid leukaemia 2A60 Phase 1 [6]
AMG 397 DM7CNTG Refractory hematologic malignancy 2A85.5 Phase 1 [7]
PMID27744724-Compound-18 DM73S2C N. A. N. A. Patented [8]
Indole-based analog 2 DM0NEVC N. A. N. A. Patented [8]
PMID27744724-Compound-10 DMFKS2P N. A. N. A. Patented [8]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PURPUROGALLIN DM63O4F N. A. N. A. Terminated [9]
TW-37 DMDE8YS Discovery agent N.A. Investigative [10]
4,5-dibenzylbenzene-1,2-diol DMHURXY Discovery agent N.A. Investigative [11]
ISIS 11219 DMW3145 Discovery agent N.A. Investigative [12]
ISIS 11220 DMNJS0K Discovery agent N.A. Investigative [12]
ISIS 11224 DMMGA6K Discovery agent N.A. Investigative [12]
ISIS 11223 DM7LPI4 Discovery agent N.A. Investigative [12]
ISIS 16010 DMZID0W Discovery agent N.A. Investigative [12]
ISIS 16009 DMBRKFC Discovery agent N.A. Investigative [12]
ISIS 15998 DMAQ9EB Discovery agent N.A. Investigative [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MCI-186 DM8ZHP1 Amyotrophic lateral sclerosis 8B60.0 Approved [13]
Taxol DMUOT9V Breast cancer 2C60-2C65 Approved [14]
GDC-0199 DMH0QKA Chronic lymphocytic leukaemia 2A82.0 Approved [15]
ABT-263 DMNE56X Myelofibrosis 2A20.2 Phase 3 [16]
Taxol/Paraplatin/Herceptin DML6GAN Breast cancer 2C60-2C65 Phase 3 [17]
Oblimersen DM7KI4E Melanoma 2C30 Phase 3 [18]
RG7601 DMDVAFP Chronic lymphocytic leukaemia 2A82.0 Phase 3 [15]
Thymoquinone DMVDTR2 Polycystic ovarian syndrome 5A80.1 Phase 2/3 [19]
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
PI-88/Taxotere DM4FIWC Solid tumour/cancer 2A00-2F9Z Phase 2 [20]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis regulator Bcl-2 (BCL-2) TTJGNVC BCL2_HUMAN Inhibitor [1]
Bcl-x messenger RNA (BCL2L1 mRNA) TTRE6AX B2CL1_HUMAN Inhibitor [1]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) TTL53M6 MCL1_HUMAN Inhibitor [1]

References

1 Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42.
2 Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of Prelude Therapeutics.
5 Clinical pipeline report, company report or official report of AbbVie.
6 MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443.
7 Clinical pipeline report, company report or official report of Amgen.
8 Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.
9 Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25;46(20):4259-64.
10 Fragment-based deconstruction of Bcl-xL inhibitors. J Med Chem. 2010 Mar 25;53(6):2577-88.
11 Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem. 2010 May 27;53(10):3899-906.
12 US patent application no. 7,148,204, Antisense modulation of bcl-x expression.
13 Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
14 Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14.
15 ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8.
16 Clinical pipeline report, company report or official report of Roche (2009).
17 Two concurrent phase II trials of paclitaxel/carboplatin/trastuzumab (weekly or every-3-week schedule) as first-line therapy in women with HER2-overexpressing metastatic breast cancer: NCCTG study 983252. Clin Breast Cancer. 2005 Dec;6(5):425-32.
18 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
19 Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.
20 Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol. 2010 Jun;21(6):1302-7.