General Information of Drug (ID: DMJHWGS)

Drug Name
NB3322 Drug Info
Indication
Disease Entry ICD 11 Status REF
Gram-positive bacterial infection 1B74-1G40 Investigative [1]
Cross-matching ID
TTD Drug ID
DMJHWGS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Proguanil DMBL79I Malaria 1F40-1F45 Approved [2]
Meprobamate DMHM93Y Anxiety Approved [3]
Pralatrexate DMAO80I Breast cancer 2C60-2C65 Approved [4]
Ustekinumab DMHTYK3 Plaque psoriasis EA90.0 Approved [5]
Trimetrexate DMDEA85 Toxoplasmosis 1F57 Approved [6]
MCB-3837 DM0R4Z5 Malaria 1F40-1F45 Approved [3]
Chlorproguanil DM1IFGT Malaria 1F40-1F45 Approved [3]
LY333531 DMGMC8H Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
Metoprine DM5GQD7 Advanced cancer 2A00-2F9Z Phase 2 [8]
Aminopterin DMQ9RBV leukaemia 2A60-2B33 Withdrawn from market [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Polypeptide deformylase (PDF) TT9SL3Q DEFM_HUMAN Inhibitor [1]

References

1 Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
2 Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6.
3 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
4 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5 Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase. Antimicrob Agents Chemother. 2002 Nov;46(11):3362-9.
6 Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. Antimicrob Agents Chemother. 2000 Nov;44(11):3092-6.
7 Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J Mol Biol. 2000 Jan 14;295(2):307-23.
8 Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34.
9 Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99.