Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJMHNL)

• Drug Name: Bethanidine Drug Info
• Synonyms: Betanidina; Betanidine; Betanidinum; Betanidole; Bethanid; Esbatal; Regulin; Tenathan; Bethanidine hemisulfate; Bethanidinesulfate; BW 467C60; BW467C60; Betanidina [INN-Spanish]; Betanidine [INN:BAN]; Betanidinum [INN-Latin]; Esbatal (TN); Regulin (TN); Tenathan (TN); Bethanidine Sulfate (2:1); Ulfate (2:1); BW-467-C-60;Bethanidine Sulfate (2:1) (USAN); Bethanidine, Sulfate (2:1); Guanidine, 1-benzyl-2,3-dimethyl-(8CI); Guanidine, 1-benzyl-2,3-dimethyl-, s; N-Benzyl-N',N''-dimethylguanidine sulfate; N,N'-dimethyl-N''-(phenylmethyl)-guanidine; Sulfuric acid compound with N''-benzyl-N,N'-dimethylguanidine (1:1); Guanidine, N, N'-dimethyl-N''-(phenylmethyl)-, sulfate (2:1); 1,2-dimethyl-3-(phenylmethyl)guanidine; 1-BENZYL-2,3-DIMETHYLGUANIDINE; 1-Benzyl-2,3-dimethylguanidine sulfate; 1-Benzyl-2,3-dimethylguanidine sulfate (1:1/2); 1-Benzyl-2,3-dimethylguanidinium sulfate; 2-Benzyl-1,3-dimethylguanidine

Indication

Disease Entry	ICD 11	Status	REF
Heart arrhythmia	BC65	Withdrawn from market	[1]

• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 2368
  ChEBI ID: CHEBI:37937
  CAS Number: CAS 55-73-2
  TTD Drug ID: DMJMHNL

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[3]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[4]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[5]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[6]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[6]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[6]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[7]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[8]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[9]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Antagonist	[2]

References

• [1] FDA Approved Drug Products from FDA Official Website. 1981. Application Number: (ANDA) 008102.
• [2] Withdrawal syndromes and the cessation of antihypertensive therapy. Arch Intern Med. 1981 Aug;141(9):1125-7.
• [3] Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
• [4] Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: involvement of beta1- and beta2-adrenergic receptors. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G269-77.
• [5] Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med. 1999 Feb;27(2):325-31.
• [6] Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6.
• [7] Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. Drugs Aging. 2006;23(12):977-95.
• [8] Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404.
• [9] beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):519-29.
• [10] beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25.