Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK18CS)

• Drug Name: [Phe3]OT Drug Info
• Synonyms: [Phe3]oxytocin; oxypressin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 164712
  CAS Number: CAS 642-35-3
  TTD Drug ID: DMK18CS

Molecule-Related Drug Atlas

Drug(s) Targeting Vasopressin V2 receptor (V2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[4]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[5]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[6]
Tolvaptan	DMIWFRL	Autosomal dominant polycystic kidney disease	GB81	Approved	[7]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[8]
Vasopressin	DMQ2FPC	Diabetes insipidus	5A61.5	Approved	[9]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[10]
Lixivaptan	DMDN4ZP	Hyponatraemia	5C72	Phase 3	[11]
Satavaptan	DME5PN3	Acute and chronic heart failure	BD1Z	Phase 3	[12]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[13]

Drug(s) Targeting Vasopressin V1a receptor (V1AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[4]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[14]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[15]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[8]
Felypressin	DMHLP9C	Localisation	N.A.	Approved	[16]
Terlipressin	DMT9FH3	Hypertension	BA00-BA04	Approved	[17]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[10]
Balovaptan	DMKMTDG	Autism spectrum disorder	6A02	Phase 3	[18]
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[19]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[13]

Drug(s) Targeting Oxytocin receptor (OTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[4]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[20]
Carbetocin	DMUSLW3	Postpartum haemorrhage	JA43	Approved	[16]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[21]
Retosiban	DMOYGZF	Preterm labour	JB00	Phase 3	[22]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[13]
Barusiban	DMWI0X3	Androgen deficiency	5A81.1	Phase 2	[23]
FE-202767	DMDGZ1C	Erectile dysfunction	HA01.1	Phase 2	[20]
GSK-557296	DM3ZL2O	Premature ejaculation	HA03.0Z	Phase 2	[24]
Pyrrolidine derivative 13	DM3VA8P	N. A.	N. A.	Patented	[25]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxytocin receptor (OTR)	TTSCIUP	OXYR_HUMAN	Agonist	[2]
Vasopressin V1a receptor (V1AR)	TT4TFGN	V1AR_HUMAN	Agonist	[3]
Vasopressin V2 receptor (V2R)	TTK8R02	V2R_HUMAN	Agonist	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2178).
• [2] Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin. FEBS Lett. 1996 Nov 18;397(2-3):201-6.
• [3] Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor. EMBO J. 1995 May 15;14(10):2176-82.
• [4] Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88.
• [5] Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 368).
• [7] Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J. 2009 May 1;419(3):577-84.
• [8] Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure. Circulation. 2001 Nov 13;104(20):2417-23.
• [9] Vasopressin receptors: structure/function relationships and signal transduction in target cells. J Soc Biol. 2005;199(4):351-9.
• [10] The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett. 2008 Jan 1;18(1):90-4.
• [11] Emerging drugs for acute and chronic heart failure: current and future developments. Expert Opin Emerg Drugs. 2007 Mar;12(1):75-95.
• [12] Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. Biochem J. 2009 Apr 15;419(2):507-17.
• [13] Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6018-22.
• [14] Nonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene. Exp Clin Endocrinol Diabetes. 1999;107(3):157-65.
• [15] Mapping peptide-binding domains of the human V1a vasopressin receptor with a photoactivatable linear peptide antagonist. J Biol Chem. 1997 Oct 17;272(42):26536-44.
• [16] Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473-512.
• [17] Investigational vasopressin receptor modulators in the pipeline. Expert Opin Investig Drugs. 2009 Aug;18(8):1119-31.
• [18] Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder. J Med Chem. 2020 Feb 27;63(4):1511-1525.
• [19] Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92.
• [20] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369).
• [21] Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9.
• [22] The Effect of an Oxytocin Receptor Antagonist (Retosiban, GSK221149A) on the Response of Human Myometrial Explants to Prolonged Mechanical Stretch.Endocrinology.2015 Oct;156(10):3511-6.
• [23] The effect of barusiban, a selective oxytocin antagonist, in threatened preterm labor at late gestational age: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2009 Jun;200(6):627.e1-10.
• [24] Inhibition of ejaculation by the non-peptide oxytocin receptor antagonist GSK557296: a multi-level site of action. Br J Pharmacol. 2013 Aug;169(7):1477-85.
• [25] A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290.