Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN0LP8)

Drug Name

Polymyxin B Sulfate Drug Info

Synonyms

Aerosporin; Polimixina B; Polymixin B sulfate; Polymxin B sulfate; Polymyxin b; Polymyxine B; Polymyxinum B; Terramycin Ophthalmic; Polimixina B [INN-Spanish]; Polymyxin B Sulfate [USAN:JAN]; Polymyxin B, sulfate; Polymyxine B [INN-French]; Polymyxinum B [INN-Latin]; Aerosporin, PMB, Poly-RX,Polymyxin B sulphate; 4-amino-N-[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-4-hydroxy-1-oxobutan-2-yl]-2-formamidobutanamide

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Blepharoconjunctivitis		Approved	[1]
Corneal abrasion	NA06.4	Approved	[1]
Keratitis		Approved	[1]
Pseudomonas infection	1B92	Approved	[2]
Urinary tract infection	GC08	Approved	[1]
Uveitis	9A96.Z	Investigative	[1]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 5702105
CAS Number: CAS 1405-20-5
TTD Drug ID: DMN0LP8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[4]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[5]
Doripenem	DM9UCJK	Cholecystitis		Approved	[6]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[3]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[7]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[8]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[9]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[10]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[6]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydropteroate synthetase (Bact folP)	TT4ILYC	DHPS_ECOLI	Binder	[3]

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References

1	Polymyxin B Sulfate FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064028.
3	Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.
4	In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
5	Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
6	Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
7	The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
8	Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
9	A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
10	Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.