Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ6YAZ)

• Drug Name: EMD-534085 Drug Info
• Synonyms: EMD-534085; 858668-07-2; EMD534085; EMD 534085; UNII-AL67QX8036; CHEMBL1077204; AL67QX8036; 1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano(3,2-C)quinolin-2-yl)methyl)urea; 1-[2-(dimethylamino)ethyl]-3-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl}urea

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 23634407
  CAS Number: CAS 858668-07-2
  TTD Drug ID: DMQ6YAZ

Molecule-Related Drug Atlas

Drug(s) Targeting Kinesin spindle messenger RNA (KIF11 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALN-VSP	DM89DHO	Liver cancer	2C12	Phase 1	[4]
N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea	DMPVKWG	Discovery agent	N.A.	Investigative	[5]
N-[3'-(trifluoromethyl)-4-biphenylyl]urea	DM7OA4R	Discovery agent	N.A.	Investigative	[5]
4'-(trifluoromethyl)-4-biphenylsulfonamide	DMLP67R	Discovery agent	N.A.	Investigative	[5]
N-(4'-chloro-4-biphenylyl)methanesulfonamide	DM0ARP8	Discovery agent	N.A.	Investigative	[5]
ISIS 183881	DMOU9EP	Discovery agent	N.A.	Investigative	[6]
ISIS 183911	DMTB350	Discovery agent	N.A.	Investigative	[7]
4'-(trifluoromethyl)-4-biphenylyl carbamate	DMT3BX9	Discovery agent	N.A.	Investigative	[5]
ISIS 183910	DMMQ2L7	Discovery agent	N.A.	Investigative	[7]
2-(difluoromethyl)-9H-carbazole	DMZVMDO	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[14]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[21]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[25]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[26]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kinesin spindle messenger RNA (KIF11 mRNA)	TTBGTCW	KIF11_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[3]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Gene/Protein Processing	[3]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[3]

References

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• [19] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [20] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [21] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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