General Information of Drug (ID: DMRHDGN)

Drug Name
TP003 Drug Info
Synonyms TP-003; TP 003
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10001434
CAS Number
CAS 628690-75-5
TTD Drug ID
DMRHDGN

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [4]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [6]
Basmisanil DMQ8J0U Alzheimer disease 8A20 Phase 2 [7]
RG-7816 DMD16JK Autism spectrum disorder 6A02 Phase 1 [8]
TBPS DMFC3XP Discovery agent N.A. Investigative [4]
AMENTOFLAVONE DMLRNV2 Discovery agent N.A. Investigative [9]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [10]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [4]
[3H]Ro154513 DMMBWKL Discovery agent N.A. Investigative [11]
[3H]CGS8216 DMLP68J Inflammation 1A00-CA43.1 Investigative [4]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [5]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [7]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [12]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [5]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [13]
Thiamylal DMHDF7B Anaesthesia 9A78.6 Approved [12]
Ganaxolone DMXJMKF Epileptic seizures 8A61-8A6Z Approved [7]
Mebutamate DM0KYI4 Anxiety disorder 6B00-6B0Z Approved [12]
Metharbital DM5A38V Epilepsy 8A60-8A68 Approved [12]
Etomidate DMZI3WO Anaesthesia 9A78.6 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [2]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [6]
PF-4480682 DMWYJHC Neuropathic pain 8E43.0 Discontinued in Phase 2 [14]
CGS-17867A DMMZJY3 Alcohol dependence 6C40.2 Terminated [15]
TBPS DMFC3XP Discovery agent N.A. Investigative [2]
AMENTOFLAVONE DMLRNV2 Discovery agent N.A. Investigative [9]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [10]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [2]
[3H]Ro154513 DMMBWKL Discovery agent N.A. Investigative [11]
[3H]CGS8216 DMLP68J Inflammation 1A00-CA43.1 Investigative [2]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [3]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [6]
Adipiplon DM821BS Sleep-wake disorder 7A00-7B2Z Phase 2 [16]
NS-2710 DMMUR6V Anxiety disorder 6B00-6B0Z Phase 2 [17]
AZD6280 DMFAZLU Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [18]
TBPS DMFC3XP Discovery agent N.A. Investigative [3]
AMENTOFLAVONE DMLRNV2 Discovery agent N.A. Investigative [9]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [10]
isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [3]
[3H]Ro154513 DMMBWKL Discovery agent N.A. Investigative [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-2 (GABRA2) TTBMV1G GBRA2_HUMAN Modulator (allosteric modulator) [2]
GABA(A) receptor alpha-3 (GABRA3) TT37EDJ GBRA3_HUMAN Modulator (allosteric modulator) [3]
GABA(A) receptor alpha-5 (GABRA5) TTNZPQ1 GBRA5_HUMAN Modulator (allosteric modulator) [4]
GABA(A) receptor gamma-3 (GABRG3) TTEX6LM GBRG3_HUMAN Modulator (allosteric modulator) [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4326).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408).
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
6 New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. J Med Chem. 1980 Jun;23(6):702-4.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
9 Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4.
10 The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8.
11 Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABA... J Med Chem. 1996 Apr 26;39(9):1928-34.
12 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
13 Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.
14 WO patent application no. 2014,1515,17, Methods of improving microvascular integrity.
15 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4.
16 Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3.
17 GABAA receptor subtype-selective modulators. I. alpha2/alpha3-selective agonists as non-sedating anxiolytics. Curr Top Med Chem. 2011;11(9):1176-202.
18 AZD6280, a novel partial -aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers.J Clin Psychopharmacol.2015 Feb;35(1):22-33.