General Information of Drug (ID: DMRK4IE)

Drug Name
Aryl piperazine derivative 15 Drug Info
Synonyms PMID30124346-Compound-33TABLE3
Cross-matching ID
PubChem CID
118190855
TTD Drug ID
DMRK4IE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting 5-HT 1 receptor (5HT1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aryl piperazine derivative 16 DM63XHT N. A. N. A. Patented [1]
Aryl piperazine derivative 14 DMY8NEL N. A. N. A. Patented [1]
RU 24969 DMVW3I9 N. A. N. A. Terminated [2]
Befiperide DMGAPH1 Anxiety disorder 6B00-6B0Z Terminated [3]
FCE-25876 DMR3ZWA Major depressive disorder 6A70.3 Terminated [4]
SRSS-023 DMUGPDB Migraine 8A80 Terminated [5]
Cyanopindolol DMIBLGH Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting 5-HT 1A receptor (HTR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [7]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [8]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [9]
Vilazodone DM4LECQ Major depressive disorder 6A70.3 Approved [10]
Flibanserin DM70DTN Depression 6A70-6A7Z Approved [11]
Gepirone DMGX5Q0 Major depressive disorder 6A70.3 Approved [12]
TERTATOLOL DM2L3D5 Hypertension BA00-BA04 Approved [13]
Urapidil DMD59GI Hypertension BA00-BA04 Approved [14]
Treximet DMU54QB Migraine 8A80 Approved [15]
CM-2395 DMASPWR Schizophrenia 6A20 Phase 3 [16]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1 receptor (5HT1R) TTWT5K7 NOUNIPROTAC Agonist [1]
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Agonist [1]

References

1 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
2 Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. Br J Pharmacol. 1986 Oct;89(2):377-84.
3 Behavioral Pharmacology of 5-ht. Paul Bevan, Paul Bevan Duphar, Alexander R. Cools. 2013. Figure(15.2).
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001389)
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019089)
6 The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT(7) receptor. Brain Res Bull. 2001 Mar 1;54(4):395-8.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
8 Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.
9 Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
10 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
11 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
12 Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
13 Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
14 Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
15 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
16 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)