Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXN9Z5)

Drug Name

UR-7198 Drug Info

Synonyms

UR-7247; UR-7280; Angiotensin II AT-1 antagonists, Uriach; UR-7280 analogs, Uriach

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Angiotensin II receptor type-1 (AGTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[3]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[4]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[3]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[3]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[5]
Telmisartan	DMS3GX2	Hypertension	BA00-BA04	Approved	[6]
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[7]
SARALASIN	DMKS1DV	Hypertension	BA00-BA04	Approved	[8]
Tasosartan	DMM13DI	Hypertension	BA00-BA04	Approved	[9]
Eprosartan	DM07K2I	Hypertension	BA00-BA04	Approved	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Antagonist	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010597)
2	Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6. J Cardiovasc Pharmacol. 2000 Mar;35(3):383-9.
3	Radioligand binding assays: application of [(125)I]angiotensin II receptor binding. Methods Mol Biol. 2009;552:131-41.
4	Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers. J Cardiovasc Pharmacol. 2009 Jul;54(1):47-56.
5	Candesartan: widening indications for this angiotensin II receptor blocker Expert Opin Pharmacother. 2009 Aug;10(12):1995-2007.
6	Deletion of angiotensin II type I receptor reduces hepatic steatosis. J Hepatol. 2009 Jun;50(6):1226-35.
7	The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75.
8	Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69.
9	Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54.
10	Clinical profile of eprosartan: a different angiotensin II receptor blocker. Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):253-7.