Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY8NEL)

• Drug Name: Aryl piperazine derivative 14 Drug Info
• Synonyms: PMID30124346-Compound-31TABLE3
• Cross-matching ID:
  PubChem CID: 118190937
  TTD Drug ID: DMY8NEL

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 1 receptor (5HT1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aryl piperazine derivative 16	DM63XHT	N. A.	N. A.	Patented	[1]
Aryl piperazine derivative 15	DMRK4IE	N. A.	N. A.	Patented	[1]
RU 24969	DMVW3I9	N. A.	N. A.	Terminated	[2]
Befiperide	DMGAPH1	Anxiety disorder	6B00-6B0Z	Terminated	[3]
FCE-25876	DMR3ZWA	Major depressive disorder	6A70.3	Terminated	[4]
SRSS-023	DMUGPDB	Migraine	8A80	Terminated	[5]
Cyanopindolol	DMIBLGH	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[7]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[8]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[9]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[10]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[11]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[12]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[13]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[14]
Treximet	DMU54QB	Migraine	8A80	Approved	[15]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[16]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1 receptor (5HT1R)	TTWT5K7	NOUNIPROTAC	Agonist	[1]
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Agonist	[1]

References

• [1] 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
• [2] Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. Br J Pharmacol. 1986 Oct;89(2):377-84.
• [3] Behavioral Pharmacology of 5-ht. Paul Bevan, Paul Bevan Duphar, Alexander R. Cools. 2013. Figure(15.2).
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001389)
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019089)
• [6] The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT(7) receptor. Brain Res Bull. 2001 Mar 1;54(4):395-8.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [8] Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.
• [9] Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
• [10] 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
• [11] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
• [12] Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
• [13] Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
• [14] Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
• [15] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [16] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)