Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ3EML)

Drug Name

Di(2,6-dimethylphenol) Drug Info

Synonyms

2417-04-1; 2,2',6,6'-tetramethyl-4,4'-biphenol; 3,3',5,5'-tetramethylbiphenyl-4,4'-diol; di(2,6-dimethylphenol); 2,2',6,6'-Tetramethyl-p,p'-biphenol; CHEMBL449983; [1,1'-Biphenyl]-4,4'-diol, 3,3',5,5'-tetramethyl-; 3,3',5,5'-tetramethyl-4,4'-diallyloxybiphenyl; 3,3,5,5-Tetramehtyl [1,1'-biphenyl] 4,4'-diol; 4-(4-hydroxy-3,5-dimethylphenyl)-2,6-dimethylphenol; 3,3',5,5'-TETRAMETHYL-4,4'-DIHYDROXYBIPHENYL; 3,3,5,5-Tetramethylbiphenyl-4,4-diol; 4,4'-dihydroxy-3,3',5,5'-tetramethyl-biphenyl

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 75490
CAS Number: CAS 2417-04-1
TTD Drug ID: DMZ3EML

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[3]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[4]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[5]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[6]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[6]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[7]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[8]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[9]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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References

1	Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11.
2	Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
3	Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
4	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
5	Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
6	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
7	Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
8	Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
9	Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
10	Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.