Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZM6FW)

• Drug Name: Oxazolyl methylthiothiazole derivative 1 Drug Info
• Synonyms: PMID26161698-Compound-52
• Cross-matching ID:
  PubChem CID: 25195503
  TTD Drug ID: DMZM6FW

Molecule-Related Drug Atlas

Drug(s) Targeting Cyclin-dependent kinase 3 (CDK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[2]
Nitrogen mustard derivative 1	DMXDSYU	N. A.	N. A.	Patented	[1]
PMID26161698-Compound-17	DMB92RA	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Cyclin-dependent kinase 9 (CDK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flavopiridol	DMKSUOI	Acute myeloid leukaemia	2A60	Phase 2	[3]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[4]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[2]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
BTX-A51	DMC8XHQ	Advanced solid tumour	2A00-2F9Z	Phase 1	[6]
CYC065	DM9ODT6	Lymphoma	2A80-2A86	Phase 1	[3]
AZD4573	DMOYPTK	Haematological malignancy	2B33.Y	Phase 1	[3]
TP-1287	DM3Z07E	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
VIP-152	DMBQ5OL	Chronic lymphocytic leukaemia	2A82.0	Phase 1	[8]
AZD7503	DM8XJD2	Non-alcoholic steatohepatitis	DB92.1	Phase 1	[9]

Drug(s) Targeting Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[4]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[4]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[11]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[2]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[13]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[14]
Roscovitine derivative 1	DMD1G3Z	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Cyclin-dependent kinase 7 (CDK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[4]
Samuraciclib	DM54FQA	Breast cancer	2C60-2C65	Phase 1/2	[15]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
BTX-A51	DMC8XHQ	Advanced solid tumour	2A00-2F9Z	Phase 1	[6]
SY-1365	DMK48PM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
LY3405105	DMB51K2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[16]
SY-5609	DMNW3LH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[17]
Roscovitine derivative 1	DMD1G3Z	N. A.	N. A.	Patented	[1]
Tricyclic benzimidazole derivative 1	DM5SD9E	N. A.	N. A.	Patented	[1]
Pyrazolo-triazine derivative 2	DML6V78	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Histone deacetylase (HDAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[19]
HBI-8000	DMDWYUN	Non-small-cell lung cancer	2C25.Y	Registered	[3]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[20]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[21]
NVP-LAQ824	DM8JWNA	Mood disorder	6A60-6E23	Phase 3	[22]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[3]
CMS-024-02	DMC4X7L	Solid tumour/cancer	2A00-2F9Z	Phase 3	[23]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[24]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[25]

Drug(s) Targeting Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[4]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
PHA848125	DMS2Q9G	Thymic cancer	2C27	Phase 2	[26]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[27]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[28]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[2]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[29]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]

Drug(s) Targeting Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[30]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[25]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[31]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[32]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[33]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[34]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[4]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[35]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[3]

Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[30]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[25]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[31]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[32]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[33]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[34]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[3]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[36]
FCN-437	DMQ8VUW	Breast cancer	2C60-2C65	Phase 1/2	[37]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 1 (CDK1)	TTH6V3D	CDK1_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 2 (CDK2)	TT7HF4W	CDK2_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 3 (CDK3)	TTMYWL7	CDK3_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 4 (CDK4)	TT0PG8F	CDK4_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 6 (CDK6)	TTO0FDJ	CDK6_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 7 (CDK7)	TTQYF7G	CDK7_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 9 (CDK9)	TT1LVF2	CDK9_HUMAN	Inhibitor	[1]
Histone deacetylase (HDAC)	TTBH0VX	NOUNIPROTAC	Inhibitor	[1]

References

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