Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZUAJ4)

• Drug Name: PMX-53 Drug Info
• Synonyms: YOKBGCTZYPOSQM-HPSWDUTRSA-N; PMX53; CHEMBL41547; (2S)-2-acetamido-N-[(3S,9S,12S,15R,18S)-15-(cyclohexylmethyl)-9-[3-(diaminomethylideneamino)propyl]-12-(1H-indol-3-ylmethyl)-2,8,11,14,17-pentaoxo-1,7,10,13,16-pentazabicyclo[1630]henicosan-3-yl]-3-phenylpropanamide; PMX 53; AcF-[OP(D-Cha)WR]; Ac-Phe-[Orn-Pro-cha-Trp-Arg]; C5aR-AP; AC1OCFH0; GTPL579; SCHEMBL16492460; SCHEMBL12971688; 219639-75-5; BDBM50111445; AcF-[OP(D-Cha)WR]; N-Acetyl-L-phenylalanyl-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-D-arginine N-52-C-16-lactam

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Phase 2	[1] , [2]

• Cross-matching ID:
  PubChem CID: 6918468
  TTD Drug ID: DMZUAJ4

Molecule-Related Drug Atlas

Drug(s) Targeting C5a anaphylatoxin chemotactic receptor (C5AR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CCX-168	DM5LQHB	Anca-associated vasculitis	4A44.A	Phase 3	[5]
NN8209	DM2TDE7	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[6]
NN8210	DM8Z5VH	Rheumatoid arthritis	FA20	Discontinued in Phase 1	[6]
PMX205	DMMXR3L	Central nervous system disease	8A04-8D87	Preclinical	[7]
RPR121154	DM9DXHM	Discovery agent	N.A.	Investigative	[8]
W54011	DMQI7BA	Discovery agent	N.A.	Investigative	[9]
C5aR pepducins	DMEK4HZ	Inflammation	1A00-CA43.1	Investigative	[8]
NDT9520492	DMFKX7Z	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Albendazole monooxygenase (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[11]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[12]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[13]
ML-3163	DM3S5UC	Discovery agent	N.A.	Investigative	[14]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol	DMH8WA2	Discovery agent	N.A.	Investigative	[15]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[16]
ML-3375	DMXJY6W	Discovery agent	N.A.	Investigative	[14]
ML-3403	DMTQWI8	Discovery agent	N.A.	Investigative	[14]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol	DM7ERYJ	Discovery agent	N.A.	Investigative	[17]
2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol	DMUGAT8	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Substance-K receptor (TACR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibodutant	DMT67EH	Irritable bowel syndrome	DD91.0	Phase 3	[18]
Rambazole	DMP2DNS	Psoriasis vulgaris	EA90	Phase 2	[19]
Nepadutant	DMPMF6L	Infantile colics	DD93.1	Phase 1/2	[20]
Saredutant	DMSRJY3	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 3	[21]
CS-003	DM1AEVT	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 2	[22]
FK-224	DM1JUS0	Asthma	CA23	Discontinued in Phase 2	[23]
DNK-333	DM4ZO01	Irritable bowel syndrome	DD91.0	Discontinued in Phase 2	[24]
AVE-5883	DM3P84V	Asthma	CA23	Discontinued in Phase 1/2	[25]
UK-224671	DMDTRJB	Urinary incontinence	MF50.2	Discontinued in Phase 1	[26]
SR 144190	DMK4XT8	Acute or chronic pain	MG30-MG31	Discontinued in Phase 1	[27]

Drug(s) Targeting Nociceptin receptor (OPRL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SER-100	DMDW5ZC	Heart failure	BD10-BD13	Phase 2	[28]
BTRX-246040	DMA9238	Major depressive disorder	6A70.3	Phase 2	[29]
LY-2940094	DMB5L6Q	Major depressive disorder	6A70.3	Phase 2	[30]
NOCICEPTIN	DMUPA7C	Headache	8A80-8A84	Phase 1	[31]
JTC-801	DMV3UN4	Pain	MG30-MG3Z	Discontinued in Phase 2	[32]
ND1251	DMMLESX	Depression	6A70-6A7Z	Discontinued in Phase 1	[33]
ATI-17000	DMZJVR5	Irritable bowel syndrome	DD91.0	Preclinical	[34]
4-phenyl-1-(1-phenylbutyl)piperidin-4-ol	DMVCIJB	Discovery agent	N.A.	Investigative	[35]
1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol	DMLYO8P	Discovery agent	N.A.	Investigative	[35]
1-benzhydryl-4-ethoxy-4-phenylpiperidine	DM6PIL2	Discovery agent	N.A.	Investigative	[35]

Drug(s) Targeting Melanocortin receptor 4 (MC4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylnaltrexone bromide	DMZTGN2	Opioid-induced constipation	DB32.1	Approved	[36]
Bremelanotide	DM20LIM	Hypoactive sexual desire dysfunction	HA00	Approved	[37]
Setmelanotide	DMPVRN9	Obesity	5B81	Approved	[38]
Amylin	DMWDEN0	N. A.	N. A.	Phase 4	[39]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[36]
PF-446687	DML38VU	Female sexual arousal dysfunction	HA01.1	Phase 2	[40]
AP-1030	DMBGA35	Metabolic disorder	5C50-5D2Z	Phase 1/2	[41]
PT-14	DMYM9JL	Erectile dysfunction	HA01.1	Discontinued in Phase 2	[42]
Melanotetan II	DMYK8MV	Obesity	5B81	Preclinical	[36]
IDDBCP-150101	DMQ3BXV	Obesity	5B81	Preclinical	[36]

Drug(s) Targeting Vasopressin V1a receptor (V1AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[43]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[44]
Oxytocin	DMDL27I	Autism spectrum disorder	6A02	Approved	[45]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[46]
Felypressin	DMHLP9C	Localisation	N.A.	Approved	[47]
Terlipressin	DMT9FH3	Hypertension	BA00-BA04	Approved	[48]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[49]
Balovaptan	DMKMTDG	Autism spectrum disorder	6A02	Phase 3	[50]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[51]
VA-111913	DMAYWXD	Dysmenorrhea	GA34.3	Phase 2	[52]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Albendazole monooxygenase (CYP3A4)	TTXV4FI	CP3A4_HUMAN	Inhibitor	[3]
C5a anaphylatoxin chemotactic receptor (C5AR1)	TTHXFA1	C5AR1_HUMAN	Modulator	[4]
Melanocortin receptor 4 (MC4R)	TTD0CIQ	MC4R_HUMAN	Inhibitor	[3]
Nociceptin receptor (OPRL1)	TTNT7K8	OPRX_HUMAN	Inhibitor	[3]
Substance-K receptor (TACR2)	TTYO0A3	NK2R_HUMAN	Inhibitor	[3]
Vasopressin V1a receptor (V1AR)	TT4TFGN	V1AR_HUMAN	Inhibitor	[3]

References

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