Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZY8UW)

• Drug Name: 4-Nitro-benzenesulfonamide Drug Info
• Synonyms: 4-NITROBENZENESULFONAMIDE; 6325-93-5; Benzenesulfonamide, 4-nitro-; p-Nitrobenzenesulfonamide; 4-Nitrobenzolesulfamide; p-Nitrophenylsulfonamide; 4-Nitrobenzenesulphonamide; Benzenesulfonamide, p-nitro-; 4-Nitro-benzenesulfonamide; UNII-TUF52O8Y8B; EINECS 228-691-6; NSC 31148; BRN 2214218; TUF52O8Y8B; CHEMBL282157; 4-Nitrobenzenesulfonamide, 97%; QWKKYJLAUWFPDB-UHFFFAOYSA-N; NsNH2; 4-nitrophenylsulfonamid; 3m8t; 4-Nitrobenzolsulfonamide; p-nitrophenyl sulfonamide; WLN: ZSWR DNW; p-nitrobenzene sulphonamide; AC1Q55AA; Cambridge id 5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 22784
  CAS Number: CAS 6325-93-5
  TTD Drug ID: DMZY8UW

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[3]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[4]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[5]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[6]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[6]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[7]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[8]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[9]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[12]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[14]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[10]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[16]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[14]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

References

• [1] Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.
• [2] Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
• [3] Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
• [4] Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
• [5] Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
• [6] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [7] Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
• [8] Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
• [9] Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
• [10] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
• [11] Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
• [12] Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
• [13] Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for th... Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73.
• [14] Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
• [15] Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
• [16] Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
• [17] Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740.