Details of the Drug Reposition

General Information of This Drug (ID: DMCVJ86)

• Drug Name: Clofarabine (DMCVJ86)
• Synonyms: CAFdA; CFB; Clofarabina; Clofarabinum; Clofarex; Clolar; Evoltra; Clofarabine [USAN]; Clolar (TN); Evoltra (TN); Clofarabine (USAN/INN); Clolar, Evoltra, Clofarabine; Cl-F-Ara-A; (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine; 2-Cl-2'-F-araA; 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine; 3S211048
• Therapeutic Class: Anticancer Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

6 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Leukemia	DISNAKFL	N.A.	Approved	[1]
Langerhans cell histiocytosis	DISDQSW3	N.A.	Approved	[1]
Myelodysplastic syndrome	DISYHNUI	2A37	Approved	[2]
Acute myelogenous leukaemia	DISCSPTN	2A41	Approved	[1]
Plasma cell myeloma	DIS0DFZ0	2A83.1	Approved	[1]
Acute lymphoblastic leukaemia	DIS87TGM	2A85	Approved	[2]

1 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Acute lymphocytic leukaemia	DISPX75S	2B33.3	Discontinued in Phase 3	[3]

1 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Classic Hodgkin lymphoma	DISV1LU6	N.A.	Investigative	[1]

References

• [1] Clofarabine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6802).
• [3] Morphine Versus Methadone As First Line Strong Opioid for Cancer Pain