Details of the Drug Reposition

General Information of This Drug (ID: DMN0LP8)

• Drug Name: Polymyxin B Sulfate (DMN0LP8)
• Synonyms: Aerosporin; Polimixina B; Polymixin B sulfate; Polymxin B sulfate; Polymyxin b; Polymyxine B; Polymyxinum B; Terramycin Ophthalmic; Polimixina B [INN-Spanish]; Polymyxin B Sulfate [USAN:JAN]; Polymyxin B, sulfate; Polymyxine B [INN-French]; Polymyxinum B [INN-Latin]; Aerosporin, PMB, Poly-RX,Polymyxin B sulphate; 4-amino-N-[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-4-hydroxy-1-oxobutan-2-yl]-2-formamidobutanamide
• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

6 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Keratitis	DISMFOEI	N.A.	Approved	[1]
Blepharoconjunctivitis	DIS4PG4J	N.A.	Approved	[1]
Bacteremia	DIS6N9RZ	1A73	Approved	[1]
Pseudomonas infection	DIS9WYLA	1B92	Approved	[2]
Urinary tract infection	DISMT6UV	GC08	Approved	[1]
Corneal abrasion	DIS3SD7J	NA06.4	Approved	[1]

2 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Bacterial conjunctivitis	DIST79FU	N.A.	Discontinued in Phase 2	[3]
Otitis externa	DISYCORK	AA00-AA13	Discontinued in Phase 2	[4]

1 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Uveitis	DISV0RYS	9A96.Z	Investigative	[1]

References

• [1] Polymyxin B Sulfate FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064028.
• [3] Pilot Study of Cyclobenzaprine for Treatment of Sleep Disturbance in Aromatase Inhibitor-treated Breast Cancer Patients
• [4] Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab Plus Carboplatin For Treatment Of Relapsed/Refractory GBM And Anaplastic Astrocytoma