General Information of Disease (ID: DIS6N9RZ)

Disease Name Bacteremia
Synonyms bacterial sepsis; bacteremia; Bacteremias; symptomatic bacteremia
Disease Class 1A70-1A7Z: Gonococcal infection
Definition An infectious disease caused by bacteria causing sepsis.
Disease Hierarchy
DIS5QJ9S: Bacterial infection
DIS6N9RZ: Bacteremia
ICD Code
ICD-11
ICD-11: 1A73
ICD-10
ICD-10: A54.4, A54.8
Disease Identifiers
MONDO ID
MONDO_0005229
MESH ID
D016470
UMLS CUI
C0004610
MedGen ID
482
HPO ID
HP:0031864
SNOMED CT ID
5758002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 32 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Amikacin DM5PDRB Approved Small molecular drug [1]
Ampicillin DMHWE7P Approved Small molecular drug [2]
Azlocillin DMIR5QP Approved Small molecular drug [3]
Cefalotin DMVYSLE Approved Small molecular drug [4]
Cefamandole DMNEXZF Approved Small molecular drug [5]
Cefazolin DMPDYFR Approved Small molecular drug [6]
Cefonicid DMTX2BH Approved Small molecular drug [7]
Cefotaxime DMEB837 Approved NA [8]
Cefotetan DM07TX3 Approved Small molecular drug [9]
Cefoxitin DMY8NC4 Approved NA [10]
Ceftazidime DM41GRA Approved Small molecular drug [11]
Ceftizoxime DM3VOGS Approved Small molecular drug [12]
Ceftriaxone DMCEW64 Approved Small molecular drug [13]
Cefuroxime DMSIMD8 Approved Small molecular drug [14]
Cephapirin DMV2JNY Approved Small molecular drug [15]
Cilastatin DME2H5T Approved Small molecular drug [16]
Clavulanate DM2FGRT Approved Small molecular drug [17]
Clindamycin DM15HL8 Approved Small molecular drug [18]
Erythromycin DM4K7GQ Approved Small molecular drug [19]
Fusidic Acid DMWVCF3 Approved Small molecular drug [20]
Gentamicin DMKINJO Approved Small molecular drug [21]
Imipenem DMI9FBP Approved Small molecular drug [16]
Kanamycin DM2DMPO Approved Small molecular drug [22]
Linezolid DMGFPU2 Approved Small molecular drug [23]
Meticillin DMIKHN0 Approved Small molecular drug [24]
Metronidazole DMTIVEN Approved Small molecular drug [25]
Mezlocillin DMY5JEP Approved Small molecular drug [26]
Piperacillin DMTBKF3 Approved Small molecular drug [27]
Polymyxin B Sulfate DMN0LP8 Approved Small molecular drug [28]
Ticarcillin DM4ME02 Approved Small molecular drug [29]
Tobramycin DMUI0CH Approved Small molecular drug [30]
Vancomycin DM3JFIH Approved NA [31]
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⏷ Show the Full List of 32 Drug(s)
This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Exebacase DMXRCL2 Phase 3 Recombinant protein [32]
SAL-200 DMIWL5P Phase 2 NA [34]
HLF 1-11 DMDFG1O Phase 1/2 Peptide [35]
DSTA-4637S DMHC09K Phase 1 Antibody drug conjugate [36]
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This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial
Drug Name Drug ID Highest Status Drug Type REF
Heparin DM4ZP3W Phase 2/3 Trial Small molecular drug [33]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 19 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CPB2 TTP18AY Limited Biomarker [37]
PLAT TTXAGYU Limited Therapeutic [38]
TIRAP TTKU0LS Limited Biomarker [39]
ITGAM TTB69FJ moderate Altered Expression [40]
NOD2 TTYPUHA moderate Biomarker [41]
ADAMTS13 TTUREBK Strong Altered Expression [42]
CD248 TTYJWT7 Strong Biomarker [43]
CPE TTXPWO6 Strong Biomarker [44]
GALNS TTT9YPO Strong Biomarker [45]
GAST TT4LRVO Strong Biomarker [45]
GPR182 TTT23CG Strong Biomarker [46]
GRHL2 TTUGH4C Strong Altered Expression [47]
LNPEP TTY2KP7 Strong Genetic Variation [48]
SLC25A1 TTTD730 Strong Biomarker [49]
CS TTZA6B3 Definitive Genetic Variation [50]
DAPK3 TTERVQN Definitive Biomarker [51]
F12 TTRJSMV Definitive Biomarker [52]
IRAK4 TTILUKB Definitive Biomarker [53]
LCT TTA0OSE Definitive Biomarker [54]
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⏷ Show the Full List of 19 DTT(s)
This Disease Is Related to 55 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
PGLYRP4 OTI115BR Limited Biomarker [55]
GLRX5 OTE3L48D moderate Biomarker [56]
AMBP OTLU8GU8 Strong Genetic Variation [57]
APBB3 OTNUTR0N Strong Genetic Variation [58]
CAP1 OTYM8A2N Strong Genetic Variation [48]
CISH OT8T5NYL Strong Genetic Variation [59]
EDN3 OTN7Q9BE Strong Genetic Variation [60]
EMP1 OTSZHUHQ Strong Biomarker [61]
FOXD3 OTXYV6GO Strong Biomarker [62]
HACD1 OTEC7EP7 Strong Genetic Variation [48]
KCNMB1 OTO4KNJ4 Strong Biomarker [63]
MRTFA OTCVXASM Strong Genetic Variation [64]
OCLN OTSUTVWL Strong Altered Expression [65]
PAGR1 OTXR5PQ8 Strong Biomarker [45]
PGLYRP2 OTF8319A Strong Biomarker [66]
PIP OTH719AH Strong Biomarker [67]
PTPRG OT9N2WOF Strong Genetic Variation [68]
SAG OTDNS3ZQ Strong Genetic Variation [69]
SERPINB6 OT7G55IK Strong Genetic Variation [48]
SFTPA2 OT6SFOMU Strong Genetic Variation [70]
SORBS1 OTWH8762 Strong Genetic Variation [48]
SUMF2 OT37I8JL Strong Biomarker [71]
TFF2 OTRXB19X Strong Biomarker [72]
ASAP2 OTGEXULW Definitive Biomarker [73]
BRAP OTB7BAFQ Definitive Biomarker [74]
CDON OT81X593 Definitive Biomarker [51]
CSH1 OT33HTRR Definitive Genetic Variation [75]
CSH2 OTW8JVAN Definitive Genetic Variation [75]
DEFB103B OT8RWY64 Definitive Genetic Variation [76]
DEFB104A OTLQZR6K Definitive Biomarker [76]
ERCC8 OT0T4WKI Definitive Genetic Variation [75]
GPSM1 OTA0SJBG Definitive Genetic Variation [77]
HLA-DRA OT7KZMP2 Definitive Altered Expression [78]
IARS1 OT9WXH5N Definitive Biomarker [79]
IL12RB1 OTM1IJO2 Definitive Genetic Variation [80]
IMP4 OTYF1USY Definitive Biomarker [81]
IMPA1 OTBUVW1Z Definitive Biomarker [74]
IPO4 OT2N5020 Definitive Biomarker [81]
MARCHF2 OTADQ0OA Definitive Biomarker [82]
MAVS OTTQ0J64 Definitive Biomarker [83]
MRPS30 OTDXIAGG Definitive Biomarker [73]
MTPAP OT6HQ02S Definitive Biomarker [73]
NFKBIE OTLAYEL9 Definitive Genetic Variation [84]
PAPOLA OTPHD65D Definitive Biomarker [73]
PDAP1 OTJSWMOD Definitive Biomarker [73]
PHB2 OTCAX3AW Definitive Genetic Variation [85]
PHF20 OTCBVH5P Definitive Biomarker [86]
RAB3IL1 OT18H5HD Definitive Altered Expression [87]
RNASEH2C OTJL9ZRN Definitive Genetic Variation [77]
SETD1A OTVVWRIC Definitive Biomarker [88]
SH3BP4 OTVIRKW7 Definitive Biomarker [89]
SIL1 OTDI85I5 Definitive Genetic Variation [85]
SPPL2B OTI1PHMP Definitive Biomarker [81]
SUFU OT0IRYG1 Definitive Genetic Variation [90]
TNMD OTHLVA9G Definitive Genetic Variation [91]
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⏷ Show the Full List of 55 DOT(s)

References

1 Amikacin FDA Label
2 Ampicillin FDA Label
3 Azlocillin FDA Label
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5 Cefamandole FDA Label
6 Cefazolin FDA Label
7 Cefonicid FDA Label
8 Cefotaxime FDA Label
9 Cefotetan FDA Label
10 Cefoxitin FDA Label
11 Ceftazidime FDA Label
12 Ceftizoxime FDA Label
13 Ceftriaxone FDA Label
14 Cefuroxime FDA Label
15 Cephapirin FDA Label
16 Cilastatin FDA Label
17 Clavulanate FDA Label
18 Clindamycin FDA Label
19 Erythromycin FDA Label
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21 Gentamicin FDA Label
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25 Metronidazole FDA Label
26 Mezlocillin FDA Label
27 Piperacillin FDA Label
28 Polymyxin B Sulfate FDA Label
29 Ticarcillin FDA Label
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61 Oral Fluoroquinolone or Trimethoprim-sulfamethoxazole vs. -lactams as Step-Down Therapy for Enterobacteriaceae Bacteremia: Systematic Review and Meta-analysis.Open Forum Infect Dis. 2019 Aug 14;6(10):ofz364. doi: 10.1093/ofid/ofz364. Online ahead of print.
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63 Group A Streptococcus Induces LAPosomes via SLO/1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy.mBio. 2019 Oct 1;10(5):e02148-19. doi: 10.1128/mBio.02148-19.
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74 Molecular and epidemiological characterization of IMP-type metallo--lactamase-producing Enterobacter cloacae in a Large tertiary care hospital in Japan.Antimicrob Agents Chemother. 2014 Jun;58(6):3441-50. doi: 10.1128/AAC.02652-13. Epub 2014 Apr 7.
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