Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM69G8X)

Drug Name

L-glutamine Drug Info

Synonyms

NutreStore; AES-14; Aesgen-14; Glutamine (INN); L-glutamine (oral, short bowel syndrome), Emmaus; L-glutamine (topical, chemotherapy-induced mucositis), Aesgen; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus/University of California Los Angeles

Indication

Disease Entry	ICD 11	Status	REF
Short bowel syndrome	KB89.1	Approved	[1] , [2] , [3]

Cross-matching ID

PubChem CID: 5961
ChEBI ID: CHEBI:18050
CAS Number: CAS 56-85-9
TTD Drug ID: DM69G8X
VARIDT Drug ID: DR00024

Molecule-Related Drug Atlas

Molecule Type:

DTP

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Virus infection	1A24-1D9Z	Approved	[7]
Ganciclovir	DM1MBYQ	Virus infection	1A24-1D9Z	Approved	[7]
Levacecarnine HCL	DMJBOCR	Cognitive impairment	6D71	Approved	[8]
Glycine	DMIOZ29	Malnutrition	5B50-5B71	Approved	[9]
Valaciclovir	DMHKS94	Virus infection	1A24-1D9Z	Approved	[10]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[11]
Nitric Oxide	DM1RBYG	Respiratory failure	CB41	Approved	[12]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[13]
L-threonine	DMFHTBX	Discovery agent	N.A.	Investigative	[13]
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⏷ Show the Full List of 9 Drug(s)

Drug(s) Transported By Sodium-coupled neutral amino acid transporter 1 (SLC38A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 3 (SLC38A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[14]
L-alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
Aminosalicylic acid	DMENSL5	Inflammatory bowel disease	DD72	Approved	[15]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 4 (SLC38A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 5 (SLC38A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
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Drug(s) Transported By Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[16]
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Drug(s) Transported By L-type amino acid transporter 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[17]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[18]
Pregabalin	DMDVP3B	Chronic obstructive pulmonary disease	CA22	Approved	[19]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium-coupled neutral amino acid transporter 3 (SLC38A3)	DTKWJH3	S38A3_HUMAN	Substrate	[4]
Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7)	DT2EGUN	S38A7_HUMAN	Substrate	[4]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5)	DTLX28N	S38A5_HUMAN	Substrate	[4]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4)	DTPJBD5	S38A4_HUMAN	Substrate	[4]
Sodium-coupled neutral amino acid transporter 2 (SLC38A2)	DTTWL58	S38A2_HUMAN	Substrate	[4]
Sodium-coupled neutral amino acid transporter 1 (SLC38A1)	DTD815L	S38A1_HUMAN	Substrate	[4]
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)	DTW7AE3	AAAT_HUMAN	Substrate	[5]
L-type amino acid transporter 1 (SLC7A5)	DT48T0N	LAT1_HUMAN	Substrate	[6]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 723).
2	2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.
5	High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5.
6	Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34.
7	Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64.
8	A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochem Biophys Res Commun. 2008 Nov 14;376(2):267-70.
9	Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53.
10	Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.
11	Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10.
12	Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005 Apr 25;579(11):2499-506.
13	D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.
14	Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol. 1995 Jun 16;49(12):1759-67.
15	Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66.
16	Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2. Clin Pharmacol Ther. 2019 Jan 16.
17	Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. Sci Rep. 2017 Mar 8;7:43580.
18	Transport of gabapentin by LAT1 (SLC7A5). Biochem Pharmacol. 2013 Jun 1;85(11):1672-83.
19	Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246.