Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNX2CS)

• DTT Name: Plasmodium Enoyl-ACP reductase (Malaria fabI) DTT Info
• UniProt ID: Q965D5_PLAFA
• Gene Name: Malaria fabI

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[1], [2], [3], [4]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[5]

36 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[6]
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol	DM4XL8Z	Discovery agent	N.A.	Investigative	[7]
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol	DME3FUD	Discovery agent	N.A.	Investigative	[8]
2-(2,4-dichlorophenoxy)-5-ethylphenol	DMPSR1O	Discovery agent	N.A.	Investigative	[8]
2-(2,4-dichlorophenoxy)-5-isobutylphenol	DMKOFRE	Discovery agent	N.A.	Investigative	[7]
2-(2,4-dichlorophenoxy)-5-isopentylphenol	DME0LZ2	Discovery agent	N.A.	Investigative	[7]
2-(2,4-dichlorophenoxy)-5-methylphenol	DM1L3US	Discovery agent	N.A.	Investigative	[8]
2-(2,4-dichlorophenoxy)-5-phenethylphenol	DM6ZNR3	Discovery agent	N.A.	Investigative	[7]
2-(2,4-dichlorophenoxy)-5-propylphenol	DMKP974	Discovery agent	N.A.	Investigative	[8]
2-(2-((benzylamino)methyl)phenoxy)-5-chlorophenol	DMGZKCT	Discovery agent	N.A.	Investigative	[9]
2-(4-amino-2-chlorophenoxy)-5-chlorophenol	DMUANX1	Discovery agent	N.A.	Investigative	[10]
2-(4-chloro-2-hydroxyphenoxy)benzenaminium	DMBHFIM	Discovery agent	N.A.	Investigative	[7]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[6]
3,7-dihydroxy-flavone	DMH04P7	Discovery agent	N.A.	Investigative	[6]
3-chloro-4-(4-chloro-2-hydroxyphenoxy)benzamide	DMZ5JFG	Discovery agent	N.A.	Investigative	[10]
4-(2,4-dichloro-phenoxy)-2'-methyl-biphenyl-3-ol	DMPKE6G	Discovery agent	N.A.	Investigative	[8]
4-(2,4-dichloro-phenoxy)-4'-fluoro-biphenyl-3-ol	DMAK789	Discovery agent	N.A.	Investigative	[8]
4-(2,4-dichloro-phenoxy)-biphenyl-3-ol	DMB96SY	Discovery agent	N.A.	Investigative	[8]
4-(2,4-dichlorophenoxy)-3'-methylbiphenyl-3-ol	DMY6GWF	Discovery agent	N.A.	Investigative	[7]
4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile	DMS7POY	Discovery agent	N.A.	Investigative	[8]
4-(2,4-dichlorophenoxy)-4'-methylbiphenyl-3-ol	DMRPVO3	Discovery agent	N.A.	Investigative	[7]
4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole	DMX681M	Discovery agent	N.A.	Investigative	[11]
5-benzyl-2-(2,4-dichlorophenoxy)phenol	DM5MJ3I	Discovery agent	N.A.	Investigative	[7]
5-butyl-2-(2,4-dichlorophenoxy)phenol	DMCNU6I	Discovery agent	N.A.	Investigative	[7]
5-chloro-2-(2-chloro-4-hydroxyphenoxy)phenol	DMDZ8NA	Discovery agent	N.A.	Investigative	[10]
5-chloro-2-(2-chloro-4-nitrophenoxy)phenol	DMAJ8BS	Discovery agent	N.A.	Investigative	[10]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[11]
BUTEIN	DM8E54P	Discovery agent	N.A.	Investigative	[5]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[3]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[6]
Indole Naphthyridinone	DMB4ZNW	Discovery agent	N.A.	Investigative	[11]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[6]
Morin	DM2OGZ5	Discovery agent	N.A.	Investigative	[6]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[11]
OROIDIN	DMA2DQT	Discovery agent	N.A.	Investigative	[12]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[1]

References

• [1] Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
• [2] The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
• [3] Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.
• [4] Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
• [5] Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
• [6] Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
• [7] Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19.
• [8] X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44.
• [9] Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan der... Bioorg Med Chem Lett. 2006 Apr 15;16(8):2163-9.
• [10] Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. ... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52.
• [11] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [12] Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tubercul... Bioorg Med Chem. 2007 Nov 1;15(21):6834-45.