Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEO1IE3)

• DME Name: Cytochrome P450 3A43 (CYP3A43) DME Info
• Gene Name: CYP3A43

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethosuximide	DMDZ9LT	Epilepsy	8A60-8A68	Approved	[1]
Oxazepam	DMXNZM4	Alcohol withdrawal delirium		Approved	[2]
Praziquantel	DMOU1PK	Flatworm infection	1F70-1F86	Approved	[3]
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[4]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[5]

References

• [1] Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76.
• [2] Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica. 2000 Jan;30(1):27-46.
• [3] Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers. Clin Pharmacol Ther. 2002 Nov;72(5):505-13.
• [4] cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol. 2001 Feb;59(2):386-92.
• [5] Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209.