Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT0OC1Q)

• DTP Name: Organic anion transporter 2 (SLC22A7) DTP Info
• Gene Name: OAT2

Molecule-Related Drug & Molecule List

15 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[1]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[2]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[3]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[4]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[5]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[6]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[7]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[4]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[9]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[10]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[11]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[7]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[12]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[13]

References

• [1] Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol. 2008 Apr;73(4):1151-8.
• [2] Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14.
• [3] Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82.
• [4] Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
• [5] Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
• [6] Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter. Drug Metab Pharmacokinet. 2017 Feb;32(1):116-119.
• [7] Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22.
• [8] Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158.
• [9] In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica. 2018 Oct;48(10):1037-1049.
• [10] A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
• [11] Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
• [12] Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
• [13] Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802.