General Information of DTP (ID: DTW7AE3)

DTP Name Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTP Info
UniProt ID
AAAT_HUMAN
Gene Name ASCT2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Investigative Drug(s)
9 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Virus infection 1A24-1D9Z Approved [1]
Ganciclovir DM1MBYQ Virus infection 1A24-1D9Z Approved [1]
Glycine DMIOZ29 Malnutrition 5B50-5B71 Approved [2]
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [3]
Levacecarnine HCL DMJBOCR Cognitive impairment 6D71 Approved [4]
Nitric Oxide DM1RBYG Respiratory failure CB41 Approved [5]
Valaciclovir DMHKS94 Virus infection 1A24-1D9Z Approved [6]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [7]
D-Serine DM3YH4I N. A. N. A. Phase 4 [8]
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⏷ Show the Full List of 9 Approved Drug(s)
1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-threonine DMFHTBX Discovery agent N.A. Investigative [8]
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Molecule Interaction Atlas

References

1 Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64.
2 Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53.
3 High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5.
4 A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochem Biophys Res Commun. 2008 Nov 14;376(2):267-70.
5 Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005 Apr 25;579(11):2499-506.
6 Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.
7 Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10.
8 D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.