General Information of DTT (ID: TT6R7JZ)

DTT Name Histone deacetylase 1 (HDAC1) DTT Info
Gene Name HDAC1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Patented Agent(s)
4 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [1]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [2]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [1]
HBI-8000 DMDWYUN Non-small-cell lung cancer 2C25.Y Registered [3]
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12 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [4]
NVP-LAQ824 DM8JWNA Mood disorder 6A60-6E23 Phase 3 [5]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [6]
MGCD-0103 DM726HX Non-small-cell lung cancer 2C25.Y Phase 2 [1]
Phenylbutyrate DMBHPDW Urea cycle disorder 5C50.A Phase 2 [7]
Resminostat DMNE1FR Hepatocellular carcinoma 2C12.02 Phase 2 [8]
SB-623 DM4NY58 Cerebrovascular ischaemia 8B1Z Phase 2 [9]
Sodium butyrate DMKNIVG Acute myeloid leukaemia 2A60 Phase 2 [10]
CHR-3996 DMIXPNG Lymphoma 2A80-2A86 Phase 1/2 [11]
OBP-801 DMPLV9G Solid tumour/cancer 2A00-2F9Z Phase 1 [12]
RG-2833 DM7B650 Friedreich's ataxia 8A03.10 Phase 1 [3]
SB-639 DMSZIP5 Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
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⏷ Show the Full List of 12 Clinical Trial Drug(s)
76 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diaryl amine derivative 2 DMRBYAV N. A. N. A. Patented [13]
Diaryl amine derivative 3 DMLBN1T N. A. N. A. Patented [13]
Isosteric imidazolyl pyrimidine derivative 1 DMP2QDM N. A. N. A. Patented [14]
PMID28092474-Compound-32a DMGZ61E N. A. N. A. Patented [13]
PMID28092474-Compound-32b DMT2B5A N. A. N. A. Patented [13]
PMID28092474-Compound-32c DMGA3XL N. A. N. A. Patented [13]
PMID28092474-Compound-32d DMW21U4 N. A. N. A. Patented [13]
PMID28092474-Compound-32e DM8NHQS N. A. N. A. Patented [13]
PMID28092474-Compound-32f DMEIZ6Y N. A. N. A. Patented [13]
PMID28092474-Compound-32g DMTKLEP N. A. N. A. Patented [13]
PMID28092474-Compound-32h DME1WHT N. A. N. A. Patented [13]
PMID28092474-Compound-32i DMN3ZEF N. A. N. A. Patented [13]
PMID28092474-Compound-32j DMSGWTX N. A. N. A. Patented [13]
PMID28092474-Compound-32k DMHSJ65 N. A. N. A. Patented [13]
PMID28092474-Compound-32l DMSP5IA N. A. N. A. Patented [13]
PMID28092474-Compound-32m DMADMWB N. A. N. A. Patented [13]
PMID28092474-Compound-32n DMJO3RW N. A. N. A. Patented [13]
PMID28092474-Compound-32o DMV9BQN N. A. N. A. Patented [13]
PMID28092474-Compound-32p DM4ZO21 N. A. N. A. Patented [13]
PMID28092474-Compound-32q DMEASZY N. A. N. A. Patented [13]
PMID28092474-Compound-32r DMLTKMS N. A. N. A. Patented [13]
PMID28092474-Compound-32s DMS103B N. A. N. A. Patented [13]
PMID28092474-Compound-32t DM2JF0T N. A. N. A. Patented [13]
PMID28092474-Compound-32u DM805ZN N. A. N. A. Patented [13]
PMID28092474-Compound-32v DMHV3ES N. A. N. A. Patented [13]
PMID28092474-Compound-32x DML79XQ N. A. N. A. Patented [13]
PMID28092474-Compound-32y DMLR03U N. A. N. A. Patented [13]
PMID28092474-Compound-32z DMEPWGH N. A. N. A. Patented [13]
PMID28092474-Compound-33a DM7GH4Y N. A. N. A. Patented [13]
PMID28092474-Compound-33b DMIJQZV N. A. N. A. Patented [13]
PMID28092474-Compound-33c DM51JP6 N. A. N. A. Patented [13]
PMID28092474-Compound-33d DMW38MK N. A. N. A. Patented [13]
PMID28092474-Compound-33e DMGTSXL N. A. N. A. Patented [13]
PMID28092474-Compound-33f DMA360M N. A. N. A. Patented [13]
PMID28092474-Compound-33g DM18DY6 N. A. N. A. Patented [13]
PMID28092474-Compound-33h DM1DN6V N. A. N. A. Patented [13]
PMID28092474-Compound-33i DM16E95 N. A. N. A. Patented [13]
PMID28092474-Compound-33j DMNTRIZ N. A. N. A. Patented [13]
PMID28092474-Compound-33k DMF2ZNT N. A. N. A. Patented [13]
PMID28092474-Compound-33l DMPJSB2 N. A. N. A. Patented [13]
PMID28092474-Compound-33m DMXSPT9 N. A. N. A. Patented [13]
PMID28092474-Compound-33o DM6DJZ7 N. A. N. A. Patented [13]
PMID28092474-Compound-33p DMI8ZBK N. A. N. A. Patented [13]
PMID28092474-Compound-34a DMXQE7C N. A. N. A. Patented [13]
PMID28092474-Compound-34b DM6X2CO N. A. N. A. Patented [13]
PMID28092474-Compound-34c DMMI7DY N. A. N. A. Patented [13]
PMID29671355-Compound-11 DMNKABH N. A. N. A. Patented [15]
PMID29671355-Compound-13 DMALXYR N. A. N. A. Patented [15]
PMID29671355-Compound-18 DMUY53P N. A. N. A. Patented [15]
PMID29671355-Compound-19 DM9LMNB N. A. N. A. Patented [15]
PMID29671355-Compound-21 DMPJN0M N. A. N. A. Patented [15]
PMID29671355-Compound-22 DMRGV83 N. A. N. A. Patented [15]
PMID29671355-Compound-23 DMUBOEX N. A. N. A. Patented [15]
PMID29671355-Compound-24 DMCIGJ1 N. A. N. A. Patented [15]
PMID29671355-Compound-25 DMPV0KZ N. A. N. A. Patented [15]
PMID29671355-Compound-26 DM5K6MG N. A. N. A. Patented [15]
PMID29671355-Compound-27 DMP7S9E N. A. N. A. Patented [15]
PMID29671355-Compound-28 DMLXSHW N. A. N. A. Patented [15]
PMID29671355-Compound-31 DM3H78D N. A. N. A. Patented [15]
PMID29671355-Compound-38a DMYATB5 N. A. N. A. Patented [15]
PMID29671355-Compound-38b DMYXE4J N. A. N. A. Patented [15]
PMID29671355-Compound-39 DM6EJ93 N. A. N. A. Patented [15]
PMID29671355-Compound-42 DMXY103 N. A. N. A. Patented [15]
PMID29671355-Compound-43 DMVPMWJ N. A. N. A. Patented [15]
PMID29671355-Compound-44 DM80A3V N. A. N. A. Patented [15]
PMID29671355-Compound-55 DMJV1SY N. A. N. A. Patented [15]
PMID29671355-Compound-56 DM0VBMI N. A. N. A. Patented [15]
PMID29671355-Compound-57 DM57N3Y N. A. N. A. Patented [15]
PMID29671355-Compound-59 DM2F0CQ N. A. N. A. Patented [15]
PMID29671355-Compound-61 DMXH1G3 N. A. N. A. Patented [15]
PMID29671355-Compound-62 DMWRS34 N. A. N. A. Patented [15]
PMID29671355-Compound-65a DMY3Q58 N. A. N. A. Patented [15]
PMID29671355-Compound-67 DM1RPL4 N. A. N. A. Patented [15]
PMID29671355-Compound-73 DMCNF36 N. A. N. A. Patented [15]
PMID29671355-Compound-8 DM7YQJK N. A. N. A. Patented [15]
PMID29671355-Compound-9 DMXL96M N. A. N. A. Patented [15]
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⏷ Show the Full List of 76 Patented Agent(s)
4 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AN-9 DMGL0Q2 Melanoma 2C30 Discontinued in Phase 2 [10]
Tacedinaline DM1Z74X Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [9]
Pyroxamide DM4LNBQ Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [9]
Oxamflatin DM1TG3C Solid tumour/cancer 2A00-2F9Z Terminated [9]
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8 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
4SC-202 DMXFC3W Solid tumour/cancer 2A00-2F9Z Preclinical [8]
Chlamydocin DM89DQP Solid tumour/cancer 2A00-2F9Z Preclinical [9]
Depudecin DMD0T1U Solid tumour/cancer 2A00-2F9Z Preclinical [9]
HC-Toxin DMPLZ7E Solid tumour/cancer 2A00-2F9Z Preclinical [9]
M-carboxycinnamic acid bishydroxamide DMHJLPS Solid tumour/cancer 2A00-2F9Z Preclinical [9]
Scriptaid DM9JZ21 Solid tumour/cancer 2A00-2F9Z Preclinical [9]
SK-7041 DM7DNOG Solid tumour/cancer 2A00-2F9Z Preclinical [9]
SK-7068 DMCI371 Solid tumour/cancer 2A00-2F9Z Preclinical [9]
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⏷ Show the Full List of 8 Preclinical Drug(s)
146 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 Discovery agent N.A. Investigative [16]
1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one DM6GI4Z Discovery agent N.A. Investigative [17]
1,1,1-Trifluoro-8-phenoxy-octan-2-one DM41R2O Discovery agent N.A. Investigative [17]
2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 Discovery agent N.A. Investigative [18]
4-Benzenesulfonylamino-N-hydroxy-benzamide DMM6UPD Discovery agent N.A. Investigative [19]
4-Benzoylamino-N-hydroxy-benzamide DMYBPFS Discovery agent N.A. Investigative [20]
4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 Discovery agent N.A. Investigative [21]
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 Discovery agent N.A. Investigative [22]
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 Discovery agent N.A. Investigative [23]
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ Discovery agent N.A. Investigative [24]
4-Phenylbutyrohydroxamic acid DMCZKN7 Discovery agent N.A. Investigative [25]
4-tert-butyl-N-hydroxybenzamide DMUWTPX Discovery agent N.A. Investigative [26]
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS Discovery agent N.A. Investigative [27]
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL Discovery agent N.A. Investigative [18]
5-Mercapto-pentanoic acid phenylamide DMET3OJ Discovery agent N.A. Investigative [23]
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD Discovery agent N.A. Investigative [23]
6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide DMQZTS3 Discovery agent N.A. Investigative [28]
6-(9H-carbazol-9-yl)-N-hydroxyhexanamide DMVMDJ3 Discovery agent N.A. Investigative [29]
6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z Discovery agent N.A. Investigative [30]
6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 Discovery agent N.A. Investigative [30]
6-Mercapto-hexanoic acid phenylamide DMD2FW9 Discovery agent N.A. Investigative [23]
6-Phenoxy-hexane-1-thiol DMVYIN2 Discovery agent N.A. Investigative [23]
6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 Discovery agent N.A. Investigative [30]
7-(1H-indol-5-yloxy)-N-hydroxyheptanamide DMOZV9W Discovery agent N.A. Investigative [31]
7-(3-Benzoyl-ureido)-heptanoic acid hydroxyamide DMCFV0X Discovery agent N.A. Investigative [28]
7-(4-(dimethylamino)phenoxy)-N-hydroxyheptanamide DM2TNCK Discovery agent N.A. Investigative [31]
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY Discovery agent N.A. Investigative [16]
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 Discovery agent N.A. Investigative [17]
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P Discovery agent N.A. Investigative [16]
7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide DMO4YLA Discovery agent N.A. Investigative [32]
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 Discovery agent N.A. Investigative [16]
7-Biphenyl-4-yl-heptanoic acid hydroxyamide DMV54MT Discovery agent N.A. Investigative [33]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV Discovery agent N.A. Investigative [23]
7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO Discovery agent N.A. Investigative [23]
7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK Discovery agent N.A. Investigative [23]
7-Mercapto-heptanoic acid phenylamide DM4912P Discovery agent N.A. Investigative [23]
7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA Discovery agent N.A. Investigative [23]
7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 Discovery agent N.A. Investigative [23]
7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide DM03XYF Discovery agent N.A. Investigative [34]
7-Phenoxy-heptanoic acid hydroxyamide DM1FL5G Discovery agent N.A. Investigative [33]
8-(3-Benzoyl-ureido)-octanoic acid hydroxyamide DMW2NJR Discovery agent N.A. Investigative [28]
8-(4-bromophenyl)-N-hydroxy-8-oxooctanamide DMVOCWY Discovery agent N.A. Investigative [35]
8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one DMH3SDO Discovery agent N.A. Investigative [17]
8-(biphenyl-4-yl)-N-hydroxy-8-oxooctanamide DMD6VSY Discovery agent N.A. Investigative [35]
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW Discovery agent N.A. Investigative [17]
8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid DMDIGPW Discovery agent N.A. Investigative [32]
8-Mercapto-octanoic acid phenylamide DMD3FWU Discovery agent N.A. Investigative [23]
8-Oxo-8-phenyl-octanoic acid DMXDQ25 Discovery agent N.A. Investigative [24]
8-Oxo-8-phenyl-octanoic acid hydroxyamide DMWM1UL Discovery agent N.A. Investigative [22]
8-Phenyl-octanoic acid hydroxyamide DM516NE Discovery agent N.A. Investigative [33]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID Discovery agent N.A. Investigative [17]
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 Discovery agent N.A. Investigative [17]
ADS-100380 DM7U4OT Discovery agent N.A. Investigative [36]
ADS-102550 DMEU6MH Discovery agent N.A. Investigative [36]
Azithromycin-N-benzyltriazolyldecahydroxamic Acid DMDQ2VN Discovery agent N.A. Investigative [37]
Azithromycin-N-benzyltriazolylhexahydroxamic Acid DM7KD5Y Discovery agent N.A. Investigative [37]
Azithromycin-N-benzyltriazolylnonahydroxamic Acid DMW0HXO Discovery agent N.A. Investigative [37]
Azithromycin-N-benzyltriazolyloctahydroxamic Acid DMAJ4LI Discovery agent N.A. Investigative [37]
Azithromycinarylalkylhydroxamic Acid DM8ZQG3 Discovery agent N.A. Investigative [37]
AZUMAMIDE B DMXOGE8 Discovery agent N.A. Investigative [38]
AZUMAMIDE C DMEBA61 Discovery agent N.A. Investigative [38]
AZUMAMIDE E DMAX06G Discovery agent N.A. Investigative [38]
Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) DMZF35W Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) DMIVREK Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) DMLBECR Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) DMA76KW Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) DMLNJ0O Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) DMTVMWA Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) DMUSEDF Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) DMSEQ0W Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) DMBKP48 Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) DMVY89X Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) DMTDIM9 Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) DMV23XD Discovery agent N.A. Investigative [39]
Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) DM0VIH4 Discovery agent N.A. Investigative [39]
Cyclostellettamine derivative DMFTDPQ Discovery agent N.A. Investigative [40]
Desclasinose Azithromycinarylalkyl Hydroxamate DMAB9KG Discovery agent N.A. Investigative [37]
Gymnochrome E DM7SLAM Discovery agent N.A. Investigative [41]
LARGAZOLE DMSYLIJ Discovery agent N.A. Investigative [42]
N,8-dihydroxy-8-(naphthalen-2-yl)octanamide DM8G0WX Discovery agent N.A. Investigative [35]
N-(2,3-Dimethylphenyl)-N'-hydroxyoctanediamide DM5R3ZG Discovery agent N.A. Investigative [43]
N-(2,4-Dimethylphenyl)-N'-hydroxyoctanediamide DMXA9MR Discovery agent N.A. Investigative [43]
N-(2,5-Dimethylphenyl)-N'-hydroxyoctanediamide DMOL79W Discovery agent N.A. Investigative [43]
N-(2,6-Dimethylphenyl)-N'-hydroxyoctanediamide DMTBAPH Discovery agent N.A. Investigative [43]
N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide DMFYG79 Discovery agent N.A. Investigative [44]
N-(2-aminophenyl)-4-(chroman-3-ylmethyl)benzamide DMT7JUC Discovery agent N.A. Investigative [45]
N-(2-aminophenyl)-4-methoxybenzamide DMTKWUM Discovery agent N.A. Investigative [46]
N-(2-aminophenyl)nicotinamide DMRDQ1B Discovery agent N.A. Investigative [44]
N-(2-aminophenyl)quinoxaline-6-carboxamide DMJXV7C Discovery agent N.A. Investigative [46]
N-(2-Ethylphenyl)-N'-hydroxyoctanediamide DMDM50P Discovery agent N.A. Investigative [43]
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV Discovery agent N.A. Investigative [47]
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ Discovery agent N.A. Investigative [47]
N-(3,4-Dimethylphenyl)-N'-hydroxyoctanediamide DMEP2VM Discovery agent N.A. Investigative [43]
N-(3,5-Dimethylphenyl)-N'-hydroxyoctanediamide DM1L3FM Discovery agent N.A. Investigative [43]
N-(3-Ethylphenyl)-N'-hydroxyoctanediamide DMC5G6Y Discovery agent N.A. Investigative [43]
N-(4-aminobiphenyl-3-yl)nicotinamide DMXVZIY Discovery agent N.A. Investigative [44]
N-(4-Ethylphenyl)-N'-hydroxyoctanediamide DMKN8U6 Discovery agent N.A. Investigative [43]
N-(4-hydroxybiphenyl-3-yl)benzamide DMC5H8G Discovery agent N.A. Investigative [44]
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M Discovery agent N.A. Investigative [22]
N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT Discovery agent N.A. Investigative [24]
N-(6-Mercapto-hexyl)-benzamide DM01Y37 Discovery agent N.A. Investigative [23]
N-hydroxy-2,2'-bithiophene-5-carboxamide DMWIMR4 Discovery agent N.A. Investigative [36]
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A Discovery agent N.A. Investigative [20]
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 Discovery agent N.A. Investigative [20]
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 Discovery agent N.A. Investigative [20]
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB Discovery agent N.A. Investigative [48]
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY Discovery agent N.A. Investigative [20]
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT Discovery agent N.A. Investigative [20]
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY Discovery agent N.A. Investigative [21]
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 Discovery agent N.A. Investigative [21]
N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 Discovery agent N.A. Investigative [20]
N-hydroxy-5-(pyridin-2-yl)thiophene-2-carboxamide DMYKJZ2 Discovery agent N.A. Investigative [36]
N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide DMK98LE Discovery agent N.A. Investigative [36]
N-hydroxy-5-(pyridin-4-yl)thiophene-2-carboxamide DM653RM Discovery agent N.A. Investigative [36]
N-hydroxy-5-phenylthiophene-2-carboxamide DMA2WUQ Discovery agent N.A. Investigative [36]
N-hydroxy-6-oxo-6-phenylhexanamide DM0JNO2 Discovery agent N.A. Investigative [35]
N-hydroxy-7-(4-methoxyphenyl)-7-oxoheptanamide DMUXZL1 Discovery agent N.A. Investigative [35]
N-hydroxy-7-(naphthalen-2-yl)-7-oxoheptanamide DM8Z4L0 Discovery agent N.A. Investigative [35]
N-hydroxy-7-(naphthalen-2-yloxy)heptanamide DMBUNAP Discovery agent N.A. Investigative [31]
N-hydroxy-7-oxo-7-phenylheptanamide DMQW7JZ Discovery agent N.A. Investigative [35]
N-hydroxy-8-(2-methoxyphenyl)-8-oxooctanamide DMSIMNR Discovery agent N.A. Investigative [35]
N-hydroxy-8-(4-methoxyphenyl)-8-oxooctanamide DMD2K4T Discovery agent N.A. Investigative [35]
N-hydroxy-8-(naphthalen-2-yl)non-8-enamide DMRN1C6 Discovery agent N.A. Investigative [35]
N-hydroxy-8-(naphthalen-2-yl)oct-7-enamide DMGZY1Q Discovery agent N.A. Investigative [35]
N-hydroxy-8-(naphthalen-2-yl)octanamide DMXQICK Discovery agent N.A. Investigative [35]
N-hydroxy-8-oxo-8-(pyridin-3-yl)octanamide DMO4CR7 Discovery agent N.A. Investigative [35]
N-hydroxy-9-oxo-9-phenylnonanamide DMIC2A8 Discovery agent N.A. Investigative [35]
N-Hydroxy-N'-(2-methylphenyl)octanediamide DM865Y2 Discovery agent N.A. Investigative [43]
N-Hydroxy-N'-(3-methylphenyl)octanediamide DMYRC2M Discovery agent N.A. Investigative [43]
N-Hydroxy-N'-(4-methoxyphenyl)octanediamide DMELB07 Discovery agent N.A. Investigative [43]
N-Hydroxy-N'-(4-methylphenyl)octanediamide DM3DPZ8 Discovery agent N.A. Investigative [43]
N-hydroxybenzo[b]thiophene-2-carboxamide DMR4J8G Discovery agent N.A. Investigative [49]
N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide DMMQXON Discovery agent N.A. Investigative [50]
N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide DMZA8NC Discovery agent N.A. Investigative [51]
N1-hydroxy-N8-(4-phenylthiazol-2-yl)octanediamide DMOZARM Discovery agent N.A. Investigative [51]
nexturastat A DM6NS7H Discovery agent N.A. Investigative [52]
NSC-746457 DM2GO7N Discovery agent N.A. Investigative [53]
Octanedioic acid bis-hydroxyamide DMJNQ9K Discovery agent N.A. Investigative [54]
Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 Discovery agent N.A. Investigative [24]
Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK Discovery agent N.A. Investigative [24]
PSAMMAPLIN A DM6T0IQ Discovery agent N.A. Investigative [22]
SK-683 DMM32CF Discovery agent N.A. Investigative [55]
ST-2986 DMNERM6 Discovery agent N.A. Investigative [56]
ST-2987 DMWXTM8 Solid tumour/cancer 2A00-2F9Z Investigative [56]
ST-3050 DM19K2D Discovery agent N.A. Investigative [56]
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF Discovery agent N.A. Investigative [23]
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⏷ Show the Full List of 146 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32.
2 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
5 NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 1;102(7):2615-22.
6 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
7 Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
8 2011 Pipeline of 4SC AG.
9 Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92.
10 Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84.
11 A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors. Clin Cancer Res. 2012 May 1;18(9):2687-94.
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2658).
13 Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236.
14 Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
15 HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17.
16 Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13.
17 Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7.
18 New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7.
19 Design and synthesis of a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2847-50.
20 Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5.
21 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74.
22 Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116.
23 Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32.
24 Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7.
25 Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243.
26 Design of novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4619-24.
27 Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.
28 Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3314-21.
29 Inhibitors selective for HDAC6 in enzymes and cells. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70.
30 Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5.
31 Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2007 Jan 1;17(1):136-41.
32 Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5.
33 A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20.
34 Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38.
35 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76.
36 Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9.
37 Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68.
38 Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4.
39 Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9.
40 Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.
41 Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. J Nat Prod. 2010 Apr 23;73(4):712-5.
42 Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues. J Med Chem. 2010 Jun 24;53(12):4654-67.
43 Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50.
44 Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).
45 N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6729-33.
46 Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6.
47 Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72.
48 Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetyla... Eur J Med Chem. 2009 Nov;44(11):4470-6.
49 Histone deacetylase inhibitors: from bench to clinic. J Med Chem. 2008 Mar 27;51(6):1505-29.
50 Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40.
51 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6.
52 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9.
53 Histone deacetylase inhibitors through click chemistry. J Med Chem. 2008 Dec 11;51(23):7417-27.
54 Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differenti... J Med Chem. 2002 Jul 18;45(15):3296-309.
55 On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors. J Med Chem. 2004 Jun 17;47(13):3409-17.
56 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9.