Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT9SL3Q)

• DTT Name: Polypeptide deformylase (PDF) DTT Info
• UniProt ID: DEFM_HUMAN
• Gene Name: PDF

Molecule-Related Drug & Molecule List

7 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorproguanil	DM1IFGT	Malaria	1F40-1F45	Approved	[1]
MCB-3837	DM0R4Z5	Malaria	1F40-1F45	Approved	[1], [2]
Meprobamate	DMHM93Y	Anxiety disorder	6B00-6B0Z	Approved	[1]
Pralatrexate	DMAO80I	Breast cancer	2C60-2C65	Approved	[3]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[4]
Trimetrexate	DMDEA85	Toxoplasmosis	1F57	Approved	[5], [6]
Ustekinumab	DMHTYK3	Plaque psoriasis	EA90.0	Approved	[7], [4]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY333531	DMGMC8H	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
Metoprine	DM5GQD7	Advanced cancer	2A00-2F9Z	Phase 2	[9]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminopterin	DMQ9RBV	leukaemia	2A60-2B33	Withdrawn from market	[10], [11]

56 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[12]
2'-Monophosphoadenosine-5'-Diphosphate	DMDYRNF	Discovery agent	N.A.	Investigative	[12]
2-(N-Morpholino)-Ethanesulfonic Acid	DMZVHSB	Discovery agent	N.A.	Investigative	[12]
2-Allylthio-3-benzyl-6-nitro-quinazolin-4(3H)-one	DMTO1EJ	Discovery agent	N.A.	Investigative	[13]
2-Allylthio-6-amino-3-benzyl-quinazolin-4(3H)-one	DMBWGCX	Discovery agent	N.A.	Investigative	[13]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[12]
3-Benzyl-2-ethylthio-6-nitro-quinazolin-4(3H)-one	DMQ13Z8	Discovery agent	N.A.	Investigative	[13]
3-benzyl-2-mercapto-6-nitroquinazolin-4(3H)-one	DM4GWAH	Discovery agent	N.A.	Investigative	[13]
3-Phenylsulfanylmethyl-quinoxaline-5,7-diamine	DMRNHXE	Discovery agent	N.A.	Investigative	[14]
4-(2,6-diamino-9H-purin-8-yl)-2,6-dimethoxyphenol	DMH3TBQ	Discovery agent	N.A.	Investigative	[15]
5-((E)-Styryl)-quinazoline-2,4-diamine	DMH0QA7	Discovery agent	N.A.	Investigative	[16]
5-(2-fluorobenzyloxy)quinazoline-2,4-diamine	DMQCYEK	Discovery agent	N.A.	Investigative	[17]
5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine	DM3SQEY	Discovery agent	N.A.	Investigative	[12]
5-Chloryl-2,4,6-Quinazolinetriamine	DMWS3D6	Discovery agent	N.A.	Investigative	[12]
5-Formyl-6-Hydrofolic Acid	DM371WE	Discovery agent	N.A.	Investigative	[12]
5-p-Tolylsulfanyl-quinazoline-2,4-diamine	DMV4ICS	Discovery agent	N.A.	Investigative	[18]
5-Phenethyl-quinazoline-2,4-diamine	DMWI7XJ	Discovery agent	N.A.	Investigative	[16]
5-Phenylsulfanyl-2,4-Quinazolinediamine	DMMWYFR	Discovery agent	N.A.	Investigative	[12], [18]
6,7-Diphenyl-pteridine-2,4-diamine	DM7U8ID	Discovery agent	N.A.	Investigative	[19]
6-(2-Phenylsulfanyl-ethyl)-pteridine-2,4-diamine	DMKXNP0	Discovery agent	N.A.	Investigative	[19]
6-m-Tolyl-pteridine-2,4,7-triamine	DMHU78R	Discovery agent	N.A.	Investigative	[19]
6-Phenylaminomethyl-quinazoline-2,4-diamine	DMG6PZT	Discovery agent	N.A.	Investigative	[20]
6-Phenylsulfanylmethyl-pteridine-2,4-diamine	DM6GWRB	Discovery agent	N.A.	Investigative	[21]
7-Methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine	DMZKO14	Discovery agent	N.A.	Investigative	[22]
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine	DMEGSZD	Discovery agent	N.A.	Investigative	[22]
8-(2,3,4-trimethoxyphenyl)-9H-purine-2,6-diamine	DM3QV95	Discovery agent	N.A.	Investigative	[15]
8-(2,4,5-trimethoxyphenyl)-9H-purine-2,6-diamine	DM4KP5M	Discovery agent	N.A.	Investigative	[15]
8-(2,4,6-trimethoxyphenyl)-9H-purine-2,6-diamine	DM5TSJF	Discovery agent	N.A.	Investigative	[15]
8-(2,4-dimethoxyphenyl)-9H-purine-2,6-diamine	DMJPYIZ	Discovery agent	N.A.	Investigative	[15]
8-(2,5-dimethoxyphenyl)-9H-purine-2,6-diamine	DM0MIGU	Discovery agent	N.A.	Investigative	[15]
8-(2,6-Dichloro-phenyl)-9H-purine-2,6-diamine	DMECWL1	Discovery agent	N.A.	Investigative	[23]
8-(3,4,5-trimethoxyphenyl)-9H-purine-2,6-diamine	DMV63G1	Discovery agent	N.A.	Investigative	[15]
8-(3,4-dichlorophenyl)-9H-purine-2,6-diamine	DMZU0YF	Discovery agent	N.A.	Investigative	[15]
8-(3,4-dimethoxyphenyl)-9H-purine-2,6-diamine	DMYZC3I	Discovery agent	N.A.	Investigative	[15]
8-(3,5-dimethoxyphenyl)-9H-purine-2,6-diamine	DM920XR	Discovery agent	N.A.	Investigative	[15]
8-benzyl-9H-purine-2,6-diamine	DM32OQB	Discovery agent	N.A.	Investigative	[15]
8-Pyridin-4-yl-9H-purine-2,6-diamine	DM1I25F	Discovery agent	N.A.	Investigative	[23]
Biopterin	DMLNQ2F	Discovery agent	N.A.	Investigative	[12]
Brodimoprim-4,6-Dicarboxylate	DM7OF6N	Discovery agent	N.A.	Investigative	[12]
Bromo-WR99210	DMKFTW8	Discovery agent	N.A.	Investigative	[12]
Cycloguanil	DMC520D	Malaria	1F40-1F45	Investigative	[24]
DDATHF	DM6GWAC	Discovery agent	N.A.	Investigative	[12]
Dihydrofolic Acid	DM1BDM8	Discovery agent	N.A.	Investigative	[12]
Edatrexate	DM32O0L	Discovery agent	N.A.	Investigative	[10]
Furo[2,3d]Pyrimidine Antifolate	DMVYEZ1	Discovery agent	N.A.	Investigative	[12]
GNF-PF-173	DMUSAYG	Discovery agent	N.A.	Investigative	[25]
GNF-PF-607	DMJXE6K	Discovery agent	N.A.	Investigative	[26]
N*6*-Benzyl-quinazoline-2,4,6-triamine	DMRNGV0	Discovery agent	N.A.	Investigative	[26]
NB3178	DMNM6GQ	Gram-positive bacterial infection	1B74-1G40	Investigative	[27]
NB3322	DMJHWGS	Gram-positive bacterial infection	1B74-1G40	Investigative	[27]
Pergularinine	DM8OC9F	Discovery agent	N.A.	Investigative	[28]
PREMETREXED	DMVOGT4	Discovery agent	N.A.	Investigative	[29]
Ro 5-4864	DMTQP0K	Gram-positive bacterial infection	1B74-1G40	Investigative	[27]
Sri-9439	DM5GILS	Discovery agent	N.A.	Investigative	[30]
Sri-9662	DMYO4A3	Discovery agent	N.A.	Investigative	[12]
Tylophorinidine	DMHFCZA	Discovery agent	N.A.	Investigative	[28]

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