Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTK3PY9)

• DTT Name: DNA-dependent protein kinase catalytic (PRKDC) DTT Info
• UniProt ID: PRKDC_HUMAN
• Gene Name: PRKDC

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD7648	DMD9Y5T	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
M3814	DMK2L38	Locally advanced rectal cancer	2B92	Phase 1/2	[2]
M9831	DM59TI2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

103 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-Morpholin-4-yl-benzo[f]chromen-3-one	DMYOJ01	Discovery agent	N.A.	Investigative	[3]
2-(1H-indol-5-yl)-6-morpholino-4H-pyran-4-one	DMZNML4	Discovery agent	N.A.	Investigative	[4]
2-(2-aminophenyl)-6-morpholino-4H-pyran-4-one	DMCLSJZ	Discovery agent	N.A.	Investigative	[4]
2-(2-Fluoro-phenyl)-benzo[h]chromen-4-one	DMDUG9M	Discovery agent	N.A.	Investigative	[3]
2-(2-methoxyphenyl)-6-morpholino-4H-pyran-4-one	DMXVCL0	Discovery agent	N.A.	Investigative	[4]
2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one	DMAHZR9	Discovery agent	N.A.	Investigative	[5]
2-(3-acetylphenyl)-6-morpholino-4H-pyran-4-one	DMJ2NPY	Discovery agent	N.A.	Investigative	[4]
2-(3-Fluoro-phenyl)-benzo[h]chromen-4-one	DMNYWAT	Discovery agent	N.A.	Investigative	[3]
2-(3-methoxyphenyl)-6-morpholino-4H-pyran-4-one	DMASH36	Discovery agent	N.A.	Investigative	[4]
2-(4-Amino-phenyl)-benzo[h]chromen-4-one	DM2P9L5	Discovery agent	N.A.	Investigative	[3]
2-(4-chlorophenyl)-6-morpholino-4H-pyran-4-one	DM7EUOX	Discovery agent	N.A.	Investigative	[4]
2-(4-fluorophenyl)-6-morpholino-4H-pyran-4-one	DMECX8S	Discovery agent	N.A.	Investigative	[4]
2-(4-methoxyphenyl)-6-morpholino-4H-pyran-4-one	DMVQU1M	Discovery agent	N.A.	Investigative	[4]
2-(benzofuran-2-yl)-6-morpholino-4H-pyran-4-one	DMO3G6Q	Discovery agent	N.A.	Investigative	[4]
2-(furan-2-yl)-6-morpholino-4H-pyran-4-one	DM6BHUF	Discovery agent	N.A.	Investigative	[4]
2-(piperidin-1-yl)-4H-benzo[h]chromen-4-one	DMGQX1I	Discovery agent	N.A.	Investigative	[6]
2-biphenyl-4-yl-6-morpholin-4-yl-pyran-4-one	DML1W5Z	Discovery agent	N.A.	Investigative	[4]
2-dibenzofuran-4-yl-6-morpholin-4-yl-pyran-4-one	DM4A527	Discovery agent	N.A.	Investigative	[4]
2-morpholin-4-yl-6-phenyl-4H-thiopyran-4-one	DMCVF7R	Discovery agent	N.A.	Investigative	[4]
2-Morpholin-4-yl-6-phenyl-chromen-4-one	DMTB1KV	Discovery agent	N.A.	Investigative	[3]
2-morpholin-4-yl-8-naphthalen-2-ylchromen-4-one	DMC1TWI	Discovery agent	N.A.	Investigative	[6]
2-morpholin-4-yl-8-phenoxathiin-4-ylchromen-4-one	DMVN38H	Discovery agent	N.A.	Investigative	[6]
2-morpholin-4-yl-8-styrylchromen-4-one	DMNHYQ0	Discovery agent	N.A.	Investigative	[6]
2-morpholin-4-yl-8-thiophen-2-ylchromen-4-one	DM5JHT6	Discovery agent	N.A.	Investigative	[6]
2-morpholin-4-yl-8-thiophen-3-ylchromen-4-one	DMCY4EP	Discovery agent	N.A.	Investigative	[6]
2-Morpholin-4-yl-benzo[h]chromene-4-thione	DM3ZWNI	Discovery agent	N.A.	Investigative	[3]
2-Morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one	DMCKSX7	Discovery agent	N.A.	Investigative	[3]
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one	DM79ZOV	Discovery agent	N.A.	Investigative	[3]
2-morpholino-4H-benzo[g]chromen-4-one	DM5J6IT	Discovery agent	N.A.	Investigative	[6]
2-morpholino-6-(naphthalen-1-yl)-4H-chromen-4-one	DMZL6Q1	Discovery agent	N.A.	Investigative	[6]
2-morpholino-6-(naphthalen-1-yl)-4H-pyran-4-one	DMEOI0V	Discovery agent	N.A.	Investigative	[4]
2-morpholino-6-(naphthalen-2-yl)-4H-pyran-4-one	DMO7QCN	Discovery agent	N.A.	Investigative	[4]
2-morpholino-6-(quinolin-8-yl)-4H-pyran-4-one	DMTBRLK	Discovery agent	N.A.	Investigative	[4]
2-morpholino-6-(thianthren-1-yl)-4H-chromen-4-one	DMATVZB	Discovery agent	N.A.	Investigative	[6]
2-morpholino-6-(thiophen-2-yl)-4H-pyran-4-one	DMTWJMN	Discovery agent	N.A.	Investigative	[4]
2-morpholino-6-(thiophen-3-yl)-4H-pyran-4-one	DMF3NPW	Discovery agent	N.A.	Investigative	[4]
2-morpholino-6-phenyl-4H-pyran-4-one	DMMC0ZP	Discovery agent	N.A.	Investigative	[4]
2-morpholino-6-styryl-4H-pyran-4-one	DM8ZPJI	Discovery agent	N.A.	Investigative	[4]
2-morpholinobenzo[h]quinolin-4(1H)-one	DMYP0UI	Discovery agent	N.A.	Investigative	[6]
2-Pyridin-3-yl-benzo[h]chromen-4-one	DMT21UX	Discovery agent	N.A.	Investigative	[3]
2-Pyrrolidin-1-yl-benzo[h]chromen-4-one	DMGPI0C	Discovery agent	N.A.	Investigative	[3]
2-Thiomorpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one	DMSKNBA	Discovery agent	N.A.	Investigative	[3]
2-thiomorpholino-4H-benzo[h]chromen-4-one	DMFXG2E	Discovery agent	N.A.	Investigative	[6]
2-[1,4]Oxazepan-4-yl-benzo[h]chromen-4-one	DMC8IEM	Discovery agent	N.A.	Investigative	[3]
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzaldehyde	DMS9DPO	Discovery agent	N.A.	Investigative	[4]
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid	DM2VNLK	Discovery agent	N.A.	Investigative	[4]
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzonitrile	DM2J63V	Discovery agent	N.A.	Investigative	[4]
3-morpholino-1H-benzo[f]chromen-1-one	DMGWH0E	Discovery agent	N.A.	Investigative	[4]
4-(6-morpholino-4-oxo-4H-pyran-2-yl)benzonitrile	DM9O8VY	Discovery agent	N.A.	Investigative	[4]
4-Morpholin-4-yl-benzo[g]chromen-2-one	DMEJ6G9	Discovery agent	N.A.	Investigative	[3]
4-Morpholin-4-yl-benzo[h]chromen-2-one	DMW2MRP	Discovery agent	N.A.	Investigative	[3]
4-Morpholin-4-yl-chromen-2-one	DM7T3CU	Discovery agent	N.A.	Investigative	[3]
4-morpholino-6-phenyl-2H-pyran-2-one	DM8QPTJ	Discovery agent	N.A.	Investigative	[4]
4-Piperidin-1-yl-chromen-2-one	DMOHDRS	Discovery agent	N.A.	Investigative	[3]
4-Thiomorpholin-4-yl-benzo[g]chromen-2-one	DMA8SHN	Discovery agent	N.A.	Investigative	[3]
6-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one	DMA9LFR	Discovery agent	N.A.	Investigative	[6]
6-(3-hydroxyphenyl)-2-morpholino-4H-chromen-4-one	DM28DPY	Discovery agent	N.A.	Investigative	[6]
6-(4-chlorophenyl)-2-morpholin-4-ylpyridin-4-ol	DMSO2JW	Discovery agent	N.A.	Investigative	[4]
6-(4-chlorophenyl)-4-morpholino-2H-pyran-2-one	DMMTG7L	Discovery agent	N.A.	Investigative	[4]
6-(4-fluorostyryl)-2-morpholino-4H-chromen-4-one	DMKGTRF	Discovery agent	N.A.	Investigative	[6]
6-(4-hydroxyphenyl)-2-morpholino-4H-chromen-4-one	DMTYWCS	Discovery agent	N.A.	Investigative	[6]
6-(4-methoxyphenyl)-4-morpholino-2H-pyran-2-one	DMUHCO8	Discovery agent	N.A.	Investigative	[4]
6-biphenyl-2-yl-2-morpholin-4-yl-chromen-4-one	DMZPY69	Discovery agent	N.A.	Investigative	[6]
6-Chloro-4-morpholin-4-yl-chromen-2-one	DMHJIN0	Discovery agent	N.A.	Investigative	[3]
6-isopropyl-2-morpholin-4-yl-4H-thiopyran-4-one	DMGXMZL	Discovery agent	N.A.	Investigative	[4]
6-Methoxy-4-morpholin-4-yl-chromen-2-one	DMPB9MY	Discovery agent	N.A.	Investigative	[3]
6-Methyl-4-morpholin-4-yl-chromen-2-one	DMO7RPW	Discovery agent	N.A.	Investigative	[3]
6-tert-Butyl-2-morpholin-4-yl-4H-thiopyran-4-one	DMQAG1B	Discovery agent	N.A.	Investigative	[4]
7-benzoyloxy-2-(morpholin-4-yl)-chromen-4-one	DMZDP5S	Discovery agent	N.A.	Investigative	[6]
7-benzyloxy-2-(morpholin-4-yl)-chromen-4-one	DMMXAEN	Discovery agent	N.A.	Investigative	[6]
7-ethyloxyethoxy-2-morpholin-4-yl-chromen-4-one	DMXM2G7	Discovery agent	N.A.	Investigative	[6]
7-hydroxy-2-(morpholin-4-yl)chromen-4-one	DMIKSTL	Discovery agent	N.A.	Investigative	[6]
7-Methoxy-2-morpholin-4-yl-chromen-4-one	DMR713M	Discovery agent	N.A.	Investigative	[3]
7-Methoxy-4-morpholin-4-yl-chromen-2-one	DMNFIZD	Discovery agent	N.A.	Investigative	[3]
7-phenylethoxy-2-morpholin-4-yl-chromen-4-one	DMEDOFB	Discovery agent	N.A.	Investigative	[6]
7-phenyloxyethoxy-2-morpholin-4-yl-chromen-4-one	DMSBJ4M	Discovery agent	N.A.	Investigative	[6]
7-propoxy-2-(morpholin-4-yl)-chromen-4-one	DMO8WB2	Discovery agent	N.A.	Investigative	[6]
8-(1H-indol-5-yl)-2-morpholin-4-ylchromen-4-one	DMMBH9N	Discovery agent	N.A.	Investigative	[6]
8-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one	DM8SRM0	Discovery agent	N.A.	Investigative	[6]
8-(3-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one	DM15LVG	Discovery agent	N.A.	Investigative	[6]
8-(4-acetylphenyl)-2-morpholin-4-ylchromen-4-one	DMAK0P3	Discovery agent	N.A.	Investigative	[6]
8-(4-chlorophenyl)-2-morpholin-4-ylchromen-4-one	DM4186A	Discovery agent	N.A.	Investigative	[6]
8-(4-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one	DMLANGY	Discovery agent	N.A.	Investigative	[6]
8-biphenyl-2-yl-2-morpholin-4-ylchromen-4-one	DMMCAZG	Discovery agent	N.A.	Investigative	[6]
8-dibenzofuran-4-yl-2-morpholin-4-ylchromen-4-one	DMUR97N	Discovery agent	N.A.	Investigative	[6]
8-furan-2-yl-2-morpholin-4-ylchromen-4-one	DMPY9OI	Discovery agent	N.A.	Investigative	[6]
8-Methoxy-2-morpholin-4-yl-chromen-4-one	DMYE1X2	Discovery agent	N.A.	Investigative	[3]
8-Methoxy-4-morpholin-4-yl-chromen-2-one	DMHLKAE	Discovery agent	N.A.	Investigative	[3]
8-Methyl-2-morpholin-4-yl-chromen-4-one	DMLQ90D	Discovery agent	N.A.	Investigative	[3]
8-Methyl-4-morpholin-4-yl-chromen-2-one	DMVAOIG	Discovery agent	N.A.	Investigative	[3]
8-Phenyl-2-piperidin-1-yl-chromen-4-one	DM29L4D	Discovery agent	N.A.	Investigative	[3]
8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one	DMJMWOE	Discovery agent	N.A.	Investigative	[3]
Alpha-naphthoflavone	DMELOIQ	Discovery agent	N.A.	Investigative	[3]
AMA37	DMIZQOG	Discovery agent	N.A.	Investigative	[7]
Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate	DM3FH02	Discovery agent	N.A.	Investigative	[6]
IC86621	DMWRVGE	Discovery agent	N.A.	Investigative	[8]
KU-0060648	DMQWS6U	Discovery agent	N.A.	Investigative	[9]
KU-55933	DMDT42X	Solid tumour/cancer	2A00-2F9Z	Investigative	[4]
LY-292223	DML36ZE	Discovery agent	N.A.	Investigative	[5]
NU-7432	DMDNUM5	Discovery agent	N.A.	Investigative	[6]
PIK-75	DM9BQTX	Discovery agent	N.A.	Investigative	[10]
PP121	DMU8KTO	Discovery agent	N.A.	Investigative	[11]
ShRNA molecule silencing DNAPK radiosensitizer	DMTKHR3	Prostate cancer	2C82.0	Investigative	[12]

References

• [1] AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10(1):5065.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85.
• [4] Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72.
• [5] Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7.
• [6] Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46.
• [7] Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70.
• [8] Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5352-9.
• [9] 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401.
• [10] A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.
• [11] Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.
• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2800).