Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTLFGBV)

• DTT Name: Bacterial 23S ribosomal RNA (Bact 23S rRNA) DTT Info
• Gene Name: Bact 23S rRNA

Molecule-Related Drug & Molecule List

7 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[1]
Lefamulin	DME6G97	Community-acquired pneumonia	CA40.Z	Approved	[2]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[3]
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[4]
Macrolides	DM3BS97	Bacterial infection	1A00-1C4Z	Approved	[5]
Spiramycin	DM20R5F	Bacterial infection	1A00-1C4Z	Approved	[6]
Thiamphenicol	DMDRKH2	Bacterial infection	1A00-1C4Z	Approved	[7]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cethromycin	DMIGX84	Bacterial infection	1A00-1C4Z	Phase 3	[8]
EDP-420	DM5WZ0O	Bacterial infection	1A00-1C4Z	Phase 2	[9]
Oxazolidinones	DMBM47Z	Gram-positive bacterial infection	1B74-1G40	Phase 2	[10]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Micrococcin	DMJ4D1P	Discovery agent	N.A.	Investigative	[6]
Thiostrepton	DML7Y1R	Discovery agent	N.A.	Investigative	[6]

References

• [1] Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Mol Microbiol. 2004 Dec;54(5):1287-94.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [3] Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23.
• [4] Company report (JMI Laboratories)
• [5] Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
• [6] The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
• [7] The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-9-13.
• [8] How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
• [9] EDP-420, a Bicyclolide (Bridged Bicyclic Macrolide), Is Active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May; 51(5): 1666-1670.
• [10] Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.