General Information of DTT (ID: TTVG215)

DTT Name Debrisoquine 4-hydroxylase (CYP2D6) DTT Info
Gene Name CYP2D6

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glutethimide DMGE0CW Insomnia 7A00-7A0Z Approved [1]
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1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISOQUINE DMR17YI Malaria 1F40-1F45 Phase 1 [2]
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45 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine DMCHJL1 Discovery agent N.A. Investigative [3]
(5-(pyridin-3-yl)furan-2-yl)methanamine DMTC5VF Discovery agent N.A. Investigative [4]
(5-phenylfuran-2-yl)methanamine DMORD8S Discovery agent N.A. Investigative [4]
(5-pyridin-3-yl-furan-2-yl)methanethiol DMKC2BE Discovery agent N.A. Investigative [4]
1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one DMPOAB7 Discovery agent N.A. Investigative [5]
1-(3,4-DICHLOROPHENYL)-6-(METHOXYMETHYL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) DMYZ548 Discovery agent N.A. Investigative [6]
1-(4-Butoxy-phenyl)-1H-imidazole DMOEGZV Discovery agent N.A. Investigative [7]
1-(METHOXYMETHYL)-6-(NAPHTHALEN-2-YL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) DMI479T Discovery agent N.A. Investigative [6]
1H-1,2,3-benzotriazol-1-amine DM9KAI5 Discovery agent N.A. Investigative [8]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG Discovery agent N.A. Investigative [9]
2-(4-Imidazol-1-yl-phenoxymethyl)-pyridine DMUIVS9 Discovery agent N.A. Investigative [7]
2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol DMUGAT8 Discovery agent N.A. Investigative [10]
2-Hexyloxy-5-imidazol-1-yl-pyridine DMKORTS Discovery agent N.A. Investigative [7]
2-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DM8A3NI Discovery agent N.A. Investigative [7]
3-(6-Methoxynaphthalen-2-yl)pyridin-4-amine DMN75RD Discovery agent N.A. Investigative [11]
3-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DMTLJMF Discovery agent N.A. Investigative [7]
4-(3-Pent-1-ynyl-benzyl)-1H-imidazole DMEYV1B Discovery agent N.A. Investigative [12]
4-(3-Phenylethynyl-benzyl)-1H-imidazole DMS4JVT Discovery agent N.A. Investigative [12]
4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide DM0XDG6 Discovery agent N.A. Investigative [13]
4-methylaminomethyl-7-methoxycoumarin DMI1L6Q Discovery agent N.A. Investigative [14]
4-[2-(4-Imidazol-1-yl-phenoxy)-ethyl]-morpholine DM9UGO0 Discovery agent N.A. Investigative [7]
4-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DM7LV5A Discovery agent N.A. Investigative [7]
4-[5-(3-Hydroxyphenyl)-2-thienyl)-2-methyl]phenol DMK4ICB Discovery agent N.A. Investigative [10]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ Discovery agent N.A. Investigative [10]
6-(3,4-DICHLOROPHENYL)-1-[1-(METHYLOXY)-3-BUTEN-1-YL]-3-AZABICYCLO[4.1.0]HEPTANE (DIASTEREOMERIC MIX) DMZHFWX Discovery agent N.A. Investigative [6]
Bis-(5-pyridin-3-yl-thiophen-2-ylmethyl)-amine DMQ98H5 Discovery agent N.A. Investigative [15]
BMS-694153 DM8PA3U Migraine 8A80 Investigative [16]
BS 7581 DM1VF6H Discovery agent N.A. Investigative [17]
BS 7840 DMDYNBT Discovery agent N.A. Investigative [17]
BS 9106 DMQ2FDA Discovery agent N.A. Investigative [17]
Desethyl isoquine DM47JFS Discovery agent N.A. Investigative [2]
DIHYDROCUBEBIN DMZL7R6 Discovery agent N.A. Investigative [18]
GB-12819 DM7B5HA Discovery agent N.A. Investigative [17]
GBR 12530 DMPOML4 Discovery agent N.A. Investigative [17]
GBR-12289 DM2CUNP Discovery agent N.A. Investigative [17]
GNF-PF-2094 DM9J35R Discovery agent N.A. Investigative [19]
GNF-PF-4292 DMXWYMH Discovery agent N.A. Investigative [20]
GNF-PF-5411 DMZNAEQ Discovery agent N.A. Investigative [20]
Go-Y022 DMZNUAD Discovery agent N.A. Investigative [5]
ICI-199441 DMEWZ80 Discovery agent N.A. Investigative [21]
Kaempferol-3-O-methyl ether DMBG7X1 Discovery agent N.A. Investigative [22]
Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine DMQU9VD Discovery agent N.A. Investigative [15]
ML-3163 DM3S5UC Discovery agent N.A. Investigative [23]
Prodipine DMGIF1L Discovery agent N.A. Investigative [20]
SB-210313 DM5EWQN Discovery agent N.A. Investigative [24]
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⏷ Show the Full List of 45 Investigative Drug(s)
Molecule Interaction Atlas

References

1 A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses. Toxicol Ind Health. 2008 Feb-Mar;24(1-2):69-78.
2 Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15.
3 A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3816-20.
4 Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001.
5 Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31.
6 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001.
7 Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6.
8 Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5.
9 Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4.
10 New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43.
11 Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74.
12 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. J Med Chem. 2008 May 22;51(10):2944-53.
13 Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702.
14 Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. J Med Chem. 2010 Oct 14;53(19):7129-39.
15 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13;48(1):224-39.
16 Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan... J Med Chem. 2008 Aug 28;51(16):4858-61.
17 Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. J Med Chem. 2006 Apr 20;49(8):2417-30.
18 Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8.
19 Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines. Bioorg Med Chem Lett. 2010 Jan 1;20(1):228-31.
20 Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45.
21 Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity. Bioorg Med Chem Lett. 2005 May 16;15(10):2647-52.
22 Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities. J Nat Prod. 2004 Jul;67(7):1079-83.
23 Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44.
24 Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3111-6.