Details of Disease

General Information of Disease (ID: DISIHC6A)

Disease Name Autoimmune thyroid disease
Synonyms
thyroiditides, autoimmune; lymphocytic thyroiditides; thyroiditides, lymphocytic; lymphomatous thyroiditides; autoimmune thyroiditides; lymphomatous thyroiditis; thyroiditides, lymphomatous; thyroiditis, lymphocytic; thyroiditis, lymphomatous; lymphocytic thyroiditis; autoimmune thyroiditis; autoimmune thyroid gland inflammation
Definition
Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.|Disease of the thyroid gland due to autoimmunity in which the patient's immune system attacks and damages their thyroid. It can be either hyper- or hypothyroidism. (http://www.medicinenet.com/script/main/art.asp?articlekey=24314 - accessed 20th July, 2015)
Disease Hierarchy
DISTCV24: Thyroiditis
DISORMTM: Autoimmune disease
DISTWCN9: Autoimmune disorder of endocrine system
DISIHC6A: Autoimmune thyroid disease
Disease Identifiers
MONDO ID
MONDO_0005623
MESH ID
D013967
UMLS CUI
C0920350
MedGen ID
183088
SNOMED CT ID
66944004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 20 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
IKZF2 TTKT5NV Limited Biomarker [1]
TIGIT TTWNL74 Limited Altered Expression [1]
CD3G TTV3XPL moderate Biomarker [2]
DAG1 TT4X7PG moderate Genetic Variation [3]
ERAP2 TTVGS1C moderate Genetic Variation [3]
GPR35 TT254XD moderate Genetic Variation [3]
IL23R TT6H4QR moderate Genetic Variation [3]
LRRK2 TTK0FEA moderate Genetic Variation [3]
NCOA4 TT8OY02 moderate Biomarker [4]
TNFSF15 TTEST6I moderate Genetic Variation [3]
CFB TTA0P7K Strong Genetic Variation [5]
CXCL10 TTQOVYA Strong Biomarker [6]
CYP21A2 TTP4GLG Strong Genetic Variation [5]
GJA1 TT4F7SL Strong Biomarker [7]
GJB1 TTSJIRP Strong Biomarker [7]
GJB2 TTRGZX3 Strong Biomarker [7]
IL2RA TT10Y9E Strong Altered Expression [8]
IL4 TTLGTKB Strong Biomarker [9]
TSHR TT6NYJA Strong Biomarker [10]
RARG TT1Q3IE Definitive Altered Expression [11]
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⏷ Show the Full List of 20 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC5A8 DTE3TAW Limited Biomarker [12]
SLC25A27 DT0HW5C Strong Genetic Variation [13]
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This Disease Is Related to 29 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
SLAMF1 OTBTT3ZQ Limited Biomarker [14]
ADCY7 OTAWMGP3 moderate Genetic Variation [3]
ADGRL2 OTCXD2YR moderate Genetic Variation [3]
ANKRD30A OTJXYAE5 moderate Genetic Variation [3]
ANKRD55 OT62KZII moderate Genetic Variation [3]
ATG16L1 OTEOYC5D moderate Genetic Variation [3]
ATXN2L OTP5M3R9 moderate Genetic Variation [3]
C1orf141 OTASPHL0 moderate Genetic Variation [3]
CARD9 OTJ81AWD moderate Genetic Variation [3]
CRB1 OTXYUNG0 moderate Genetic Variation [3]
FNBP1 OTSJ5KKA moderate Genetic Variation [3]
FUT2 OTLXM6WI moderate Genetic Variation [3]
INS-IGF2 OTZR74BO moderate Genetic Variation [3]
LURAP1L OTSJ29M5 moderate Genetic Variation [3]
NKD1 OTY3MO97 moderate Genetic Variation [3]
SUOX OTEJQ9FC moderate Genetic Variation [3]
ATN1 OTNZFLKY Strong Biomarker [15]
BACH2 OT17GS18 Strong Genetic Variation [16]
BCL2L15 OTD943W0 Strong Genetic Variation [5]
BTNL2 OTTTEMZA Strong Genetic Variation [5]
FCRL3 OTIFXFWL Strong Altered Expression [1]
H2AC14 OT5Y4MMC Strong Biomarker [17]
HLA-DRB4 OTNXIHQU Strong Biomarker [18]
ISG20 OTCWRJJW Strong Altered Expression [8]
LPP OT6TU8SE Strong Genetic Variation [16]
MAGI3 OTDJ5QUH Strong Genetic Variation [5]
TAP2 OTWSYFI7 Strong Genetic Variation [5]
TRIM31 OT7VW6RP Strong Genetic Variation [5]
TSHB OTFDI39D Strong Altered Expression [19]
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⏷ Show the Full List of 29 DOT(s)

References

1 Expression of TIGIT and FCRL3 is Altered in T Cells from Patients with Distinct Patterns of Chronic Autoimmune Thyroiditis.Exp Clin Endocrinol Diabetes. 2019 May;127(5):281-288. doi: 10.1055/a-0597-8948. Epub 2018 Jun 11.
2 CD3G gene defects in familial autoimmune thyroiditis.Scand J Immunol. 2014 Nov;80(5):354-61. doi: 10.1111/sji.12200.
3 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.Nat Med. 2015 Sep;21(9):1018-27. doi: 10.1038/nm.3933. Epub 2015 Aug 24.
4 Papillary thyroid carcinoma: 6 cases from 2 families with associated lymphocytic thyroiditis harbouring RET/PTC rearrangements.Br J Cancer. 2001 Dec 14;85(12):1831-7. doi: 10.1054/bjoc.2001.2187.
5 Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes.J Autoimmun. 2015 Jun;60:32-9. doi: 10.1016/j.jaut.2015.03.006. Epub 2015 Apr 27.
6 Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C?.J Immunol Res. 2019 Aug 8;2019:5878960. doi: 10.1155/2019/5878960. eCollection 2019.
7 Reduced cell-cell communication in experimentally induced autoimmune thyroid disease.Endocrinology. 1996 Jul;137(7):2823-32. doi: 10.1210/endo.137.7.8770903.
8 Effect of Halofuginone on the Pathogenesis of Autoimmune Thyroid Disease in Different Mice Models.Endocr Metab Immune Disord Drug Targets. 2017;17(2):141-148. doi: 10.2174/1871530317666170424101256.
9 Vitamin D Deficiency and Immune Disorders in Combined Endocrine Pathology.Front Endocrinol (Lausanne). 2018 Oct 9;9:600. doi: 10.3389/fendo.2018.00600. eCollection 2018.
10 Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.Nat Genet. 2007 Nov;39(11):1329-37. doi: 10.1038/ng.2007.17. Epub 2007 Oct 21.
11 Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets.Oncol Lett. 2019 Oct;18(4):4270-4277. doi: 10.3892/ol.2019.10770. Epub 2019 Aug 22.
12 The impact of autoimmune thyroiditis on skin microcirculation in children with non-complicated type 1 diabetes mellitus.Microvasc Res. 2019 May;123:68-73. doi: 10.1016/j.mvr.2019.01.002. Epub 2019 Jan 3.
13 Identification of a Hashimoto thyroiditis susceptibility locus via a genome-wide comparison with Graves' disease.J Clin Endocrinol Metab. 2015 Feb;100(2):E319-24. doi: 10.1210/jc.2014-3431. Epub 2014 Nov 27.
14 Expression and Function of the Costimulatory Receptor SLAMF1 Is Altered in Lymphocytes From Patients With Autoimmune Thyroiditis.J Clin Endocrinol Metab. 2017 Feb 1;102(2):672-680. doi: 10.1210/jc.2016-2322.
15 To reflect human autoimmune thyroiditis, thyroid peroxidase (not thyroglobulin) antibodies should be measured in female (not sex-independent) NOD.H2(h4) mice.Clin Exp Immunol. 2019 Apr;196(1):52-58. doi: 10.1111/cei.13249. Epub 2019 Jan 11.
16 Seven newly identified loci for autoimmune thyroid disease.Hum Mol Genet. 2012 Dec 1;21(23):5202-8. doi: 10.1093/hmg/dds357. Epub 2012 Aug 24.
17 A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes.Cell Immunol. 2008 Jan;251(1):1-7. doi: 10.1016/j.cellimm.2008.02.002. Epub 2008 Apr 14.
18 HLA antigen expression in autoimmune endocrinopathies.Physiol Res. 2004;53(2):191-7.
19 A newly identified TSH splice variant is involved in the pathology of Hashimoto's thyroiditis.Mol Biol Rep. 2012 Dec;39(12):10019-30. doi: 10.1007/s11033-012-1871-x. Epub 2012 Jul 3.