Details of Disease

General Information of Disease (ID: DISRCR6D)

Disease Name	Vulvovaginal Candidiasis
Synonyms	monilial vulvovaginitis; candidal: [vulvovaginitis NOS] or [cervix]; candidal vulvovaginitis; vulvovaginal candidiasis; vaginal candidiasis; candidal: cervix; candidiasis of vulva and vagina
Disease Class	1F23: Candidosis
Definition	Infection of the vulva and vagina with a fungus of the genus CANDIDA. It is a disease associated with HIV infection.
Disease Hierarchy	DISS1UT7: Vulvovaginitis DISVXFB7: Vaginal infection DIS2U1JN: Cutaneous candidiasis DISIRYMU: Candidiasis DISRCR6D: Vulvovaginal Candidiasis
ICD Code	ICD-11 ICD-11: 1F23.10
Disease Identifiers	MONDO ID MONDO_0006014 MESH ID D002181 UMLS CUI C0700345 MedGen ID 195979 SNOMED CT ID 72605008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ibrexafungerp	DMK1IPV	Approved	Small molecular drug	[1]
Oteseconazole	DM7R145	Approved	Small molecular drug	[2]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
MGCD290	DMRSK2I	Phase 2	Small molecular drug	[3]
NDV-3A	DM4S5UO	Phase 2	Vaccine	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GM2A	TTGOFW6	moderate	Biomarker	[5]
LTF	TTSZDQU	moderate	Therapeutic	[6]
APCS	TTB7VAT	Strong	Altered Expression	[5]
ELK3	TT5OJMV	Strong	Altered Expression	[5]
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This Disease Is Related to 11 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CDR2	OTD3ZJST	moderate	Altered Expression	[7]
ELK4	OTVSSEOE	moderate	Biomarker	[5]
NLRC4	OTAIA3NA	moderate	Biomarker	[8]
PTPRH	OTDUHQGF	moderate	Biomarker	[5]
RNASE7	OTIXO0Z4	moderate	Altered Expression	[5]
SCLT1	OT2ZSSP4	moderate	Biomarker	[5]
CD101	OT4QX6BR	Strong	Biomarker	[9]
CLEC7A	OTRTBH27	Strong	Biomarker	[10]
LRRCC1	OTVEBJ1V	Strong	Altered Expression	[5]
PSAP	OTUOEKY7	Strong	Biomarker	[5]
SH2D1A	OTLU49I5	Strong	Altered Expression	[5]
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⏷ Show the Full List of 11 DOT(s)

References

1	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 214900.
2	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215888.
3	ClinicalTrials.gov (NCT01497223) MGCD290 and Fluconazole Versus Fluconazole Alone for the Treatment of Moderate to Severe Vulvovaginal Candidiasis. U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT01926028) Safety, Tolerability, Immunogenicity and Efficacy of NDV-3A Vaccine in Preventing Recurrent Vulvovaginal Candidiasis. U.S. National Institutes of Health.
5	Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis.Mycoses. 2007 Sep;50(5):383-90. doi: 10.1111/j.1439-0507.2007.01384.x.
6	Therapeutic potential of iron chelators in diseases associated with iron mismanagement.J Pharm Pharmacol. 2006 May;58(5):575-84. doi: 10.1211/jpp.58.5.0001.
7	Alcohol dehydrogenase I expression correlates with CDR1, CDR2 and FLU1 expression in Candida albicans from patients with vulvovaginal candidiasis.Chin Med J (Engl). 2013;126(11):2098-102.
8	Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk.Front Immunol. 2019 Oct 11;10:2364. doi: 10.3389/fimmu.2019.02364. eCollection 2019.
9	CD101 Topical Compared With Oral Fluconazole for Acute Vulvovaginal Candidiasis: A Randomized Controlled Trial.J Low Genit Tract Dis. 2019 Jul;23(3):226-229. doi: 10.1097/LGT.0000000000000473.
10	Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway.J Ethnopharmacol. 2018 Sep 15;223:51-62. doi: 10.1016/j.jep.2018.05.018. Epub 2018 May 26.