General Information of Drug Off-Target (DOT) (ID: OT4FJ0K3)

DOT Name Cholinephosphotransferase 1 (CHPT1)
Synonyms hCPT1; EC 2.7.8.2; AAPT1-like protein; Diacylglycerol cholinephosphotransferase 1
Gene Name CHPT1
Related Disease
Gastrointestinal mucositis ( )
Glioblastoma multiforme ( )
Liver cirrhosis ( )
Psoriatic arthritis ( )
Triple negative breast cancer ( )
Advanced cancer ( )
Breast neoplasm ( )
Carcinoma ( )
Carnitine palmitoyltransferase II deficiency ( )
Cataract ( )
Clear cell renal carcinoma ( )
Colon cancer ( )
Colon carcinoma ( )
Colorectal carcinoma ( )
Colorectal neoplasm ( )
Dilated cardiomyopathy 1A ( )
Epithelial ovarian cancer ( )
Fatty liver disease ( )
Hypoglycemia ( )
Lung adenocarcinoma ( )
Lung carcinoma ( )
Metabolic disorder ( )
Mitochondrial trifunctional protein deficiency ( )
Neuroblastoma ( )
Non-alcoholic fatty liver disease ( )
Non-insulin dependent diabetes ( )
Non-small-cell lung cancer ( )
Obesity ( )
Ovarian cancer ( )
Ovarian neoplasm ( )
Prostate cancer ( )
Rectal carcinoma ( )
Renal cell carcinoma ( )
Schizophrenia ( )
Small-cell lung cancer ( )
Tourette syndrome ( )
Type-1/2 diabetes ( )
Acute myelogenous leukaemia ( )
Breast cancer ( )
Hepatocellular carcinoma ( )
Leukopenia ( )
Medulloblastoma ( )
Hyperlipidemia ( )
Lung cancer ( )
Adenocarcinoma ( )
Attention deficit hyperactivity disorder ( )
Breast carcinoma ( )
Pancreatic cancer ( )
Prostate carcinoma ( )
Psychotic disorder ( )
UniProt ID
CHPT1_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
2.7.8.2
Pfam ID
PF01066
Sequence
MAAGAGAGSAPRWLRALSEPLSAAQLRRLEEHRYSAAGVSLLEPPLQLYWTWLLQWIPLW
MAPNSITLLGLAVNVVTTLVLISYCPTATEEAPYWTYLLCALGLFIYQSLDAIDGKQARR
TNSCSPLGELFDHGCDSLSTVFMAVGASIAARLGTYPDWFFFCSFIGMFVFYCAHWQTYV
SGMLRFGKVDVTEIQIALVIVFVLSAFGGATMWDYTIPILEIKLKILPVLGFLGGVIFSC
SNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATDVFEKHPCLYILM
FGCVFAKVSQKLVVAHMTKSELYLQDTVFLGPGLLFLDQYFNNFIDEYVVLWMAMVISSF
DMVIYFSALCLQISRHLHLNIFKTACHQAPEQVQVLSSKSHQNNMD
Function
Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes.
Tissue Specificity
Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines.
KEGG Pathway
Phospho.te and phosphi.te metabolism (hsa00440 )
Glycerophospholipid metabolism (hsa00564 )
Ether lipid metabolism (hsa00565 )
Metabolic pathways (hsa01100 )
Choline metabolism in cancer (hsa05231 )
Reactome Pathway
Synthesis of PC (R-HSA-1483191 )

Molecular Interaction Atlas (MIA) of This DOT

50 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Gastrointestinal mucositis DIS140OB Definitive Biomarker [1]
Glioblastoma multiforme DISK8246 Definitive Biomarker [2]
Liver cirrhosis DIS4G1GX Definitive Biomarker [3]
Psoriatic arthritis DISLWTG2 Definitive Biomarker [4]
Triple negative breast cancer DISAMG6N Definitive Biomarker [5]
Advanced cancer DISAT1Z9 Strong Biomarker [6]
Breast neoplasm DISNGJLM Strong Altered Expression [7]
Carcinoma DISH9F1N Strong Biomarker [8]
Carnitine palmitoyltransferase II deficiency DIS3GFD9 Strong Altered Expression [9]
Cataract DISUD7SL Strong Biomarker [10]
Clear cell renal carcinoma DISBXRFJ Strong Biomarker [11]
Colon cancer DISVC52G Strong Biomarker [12]
Colon carcinoma DISJYKUO Strong Biomarker [12]
Colorectal carcinoma DIS5PYL0 Strong Biomarker [13]
Colorectal neoplasm DISR1UCN Strong Biomarker [14]
Dilated cardiomyopathy 1A DIS0RK9Z Strong Altered Expression [15]
Epithelial ovarian cancer DIS56MH2 Strong Biomarker [16]
Fatty liver disease DIS485QZ Strong Altered Expression [17]
Hypoglycemia DISRCKR7 Strong Biomarker [18]
Lung adenocarcinoma DISD51WR Strong Biomarker [19]
Lung carcinoma DISTR26C Strong Biomarker [20]
Metabolic disorder DIS71G5H Strong Biomarker [21]
Mitochondrial trifunctional protein deficiency DIS2MYYR Strong Altered Expression [22]
Neuroblastoma DISVZBI4 Strong Biomarker [23]
Non-alcoholic fatty liver disease DISDG1NL Strong Biomarker [24]
Non-insulin dependent diabetes DISK1O5Z Strong Genetic Variation [25]
Non-small-cell lung cancer DIS5Y6R9 Strong Biomarker [26]
Obesity DIS47Y1K Strong Biomarker [27]
Ovarian cancer DISZJHAP Strong Biomarker [16]
Ovarian neoplasm DISEAFTY Strong Biomarker [16]
Prostate cancer DISF190Y Strong Biomarker [28]
Rectal carcinoma DIS8FRR7 Strong Biomarker [29]
Renal cell carcinoma DISQZ2X8 Strong Biomarker [11]
Schizophrenia DISSRV2N Strong Genetic Variation [30]
Small-cell lung cancer DISK3LZD Strong Biomarker [31]
Tourette syndrome DISX9D54 Strong Biomarker [32]
Type-1/2 diabetes DISIUHAP Strong Biomarker [33]
Acute myelogenous leukaemia DISCSPTN moderate Biomarker [34]
Breast cancer DIS7DPX1 moderate Biomarker [5]
Hepatocellular carcinoma DIS0J828 moderate Biomarker [35]
Leukopenia DISJMBMM moderate Genetic Variation [36]
Medulloblastoma DISZD2ZL moderate Biomarker [37]
Hyperlipidemia DIS61J3S Disputed Biomarker [33]
Lung cancer DISCM4YA Disputed Biomarker [38]
Adenocarcinoma DIS3IHTY Limited Biomarker [39]
Attention deficit hyperactivity disorder DISL8MX9 Limited Biomarker [40]
Breast carcinoma DIS2UE88 Limited Biomarker [5]
Pancreatic cancer DISJC981 Limited Biomarker [41]
Prostate carcinoma DISMJPLE Limited Biomarker [28]
Psychotic disorder DIS4UQOT Limited Genetic Variation [42]
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⏷ Show the Full List of 50 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Cholinephosphotransferase 1 (CHPT1). [43]
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9 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of Cholinephosphotransferase 1 (CHPT1). [44]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Cholinephosphotransferase 1 (CHPT1). [45]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate decreases the expression of Cholinephosphotransferase 1 (CHPT1). [46]
Vorinostat DMWMPD4 Approved Vorinostat increases the expression of Cholinephosphotransferase 1 (CHPT1). [47]
Progesterone DMUY35B Approved Progesterone increases the expression of Cholinephosphotransferase 1 (CHPT1). [48]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the expression of Cholinephosphotransferase 1 (CHPT1). [49]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 increases the expression of Cholinephosphotransferase 1 (CHPT1). [50]
THAPSIGARGIN DMDMQIE Preclinical THAPSIGARGIN increases the expression of Cholinephosphotransferase 1 (CHPT1). [51]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Cholinephosphotransferase 1 (CHPT1). [52]
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⏷ Show the Full List of 9 Drug(s)

References

1 Preventative effects of selenium-enriched Bifidobacterium longum on irinotecan-induced small intestinal mucositis in mice.Benef Microbes. 2019 May 28;10(5):569-577. doi: 10.3920/BM2018.0096. Epub 2019 Apr 9.
2 Phase 2 Study of Radiation Therapy Plus Low-Dose Temozolomide Followed by Temozolomide and Irinotecan for Glioblastoma: NRG Oncology RTOG Trial 0420.Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):878-886. doi: 10.1016/j.ijrobp.2018.11.008. Epub 2018 Nov 27.
3 Non-transplant therapies for patients with hepatocellular carcinoma and Child-Pugh-Turcotte class B cirrhosis.Lancet Oncol. 2017 Feb;18(2):e101-e112. doi: 10.1016/S1470-2045(16)30569-1.
4 Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells.Nutrients. 2019 Nov 17;11(11):2806. doi: 10.3390/nu11112806.
5 Apatinib + CPT-11 + S-1 for treatment of refractory brain metastases in patient with triple-negative breast cancer: Case report and literature review.Medicine (Baltimore). 2018 Apr;97(15):e0349. doi: 10.1097/MD.0000000000010349.
6 Development and validation of a UHPLC-MS/MS method for the identification of irinotecan photodegradation products in water samples.Environ Pollut. 2020 Jan;256:113370. doi: 10.1016/j.envpol.2019.113370. Epub 2019 Oct 10.
7 Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist.Biochem Biophys Res Commun. 2005 Jul 22;333(1):35-41. doi: 10.1016/j.bbrc.2005.05.071.
8 Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?.Cancer Biol Ther. 2007 Oct;6(10):1606-13. doi: 10.4161/cbt.6.10.4742. Epub 2007 Jul 13.
9 Normal protein content but abnormally inhibited enzyme activity in muscle carnitine palmitoyltransferase II deficiency.J Neurol Sci. 2014 Apr 15;339(1-2):183-8. doi: 10.1016/j.jns.2014.02.011. Epub 2014 Feb 20.
10 Racial/ethnic differences in rates of complex cataract surgery among United States Medicare beneficiaries.J Cataract Refract Surg. 2018 Feb;44(2):140-143. doi: 10.1016/j.jcrs.2017.10.049. Epub 2018 Mar 7.
11 Impact of Perioperative Infection on Cancer Specific Survival after Nephrectomy for Renal Cell Carcinoma.J Urol. 2017 Nov;198(5):1027-1032. doi: 10.1016/j.juro.2017.05.070. Epub 2017 May 25.
12 Synergy between dihydromyricetin intervention and irinotecan chemotherapy delays the progression of colon cancer in mouse models.Food Funct. 2019 Apr 17;10(4):2040-2049. doi: 10.1039/c8fo01756e.
13 Protective effect of curcumin against irinotecaninduced intestinal mucosal injury via attenuation of NFB activation, oxidative stress and endoplasmic reticulum stress.Int J Oncol. 2019 Apr;54(4):1376-1386. doi: 10.3892/ijo.2019.4714. Epub 2019 Feb 11.
14 Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells.Oncotarget. 2018 Jun 12;9(45):27835-27850. doi: 10.18632/oncotarget.25600. eCollection 2018 Jun 12.
15 4-O-methylhonokiol protects against diabetic cardiomyopathy in type 2 diabetic mice by activation of AMPK-mediated cardiac lipid metabolism improvement.J Cell Mol Med. 2019 Aug;23(8):5771-5781. doi: 10.1111/jcmm.14493. Epub 2019 Jun 14.
16 The role of natural killer cells in combinatorial anti-cancer therapy using Sindbis viral vectors and irinotecan.Cancer Gene Ther. 2012 Aug;19(8):588-91. doi: 10.1038/cgt.2012.33. Epub 2012 Jun 8.
17 The adiponectin promoter activator NP-1 induces high levels of circulating TNF and weight loss in obese (fa/fa) Zucker rats.Sci Rep. 2018 Jun 29;8(1):9858. doi: 10.1038/s41598-018-27871-7.
18 Fatty acid oxidation disorders: outcome and long-term prognosis.J Inherit Metab Dis. 2010 Oct;33(5):501-6. doi: 10.1007/s10545-009-9001-1. Epub 2010 Jan 5.
19 Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of -glucuronidase in tumors.Cancer Gene Ther. 2011 Jun;18(6):381-9. doi: 10.1038/cgt.2011.3. Epub 2011 Feb 25.
20 Gefitinib enhances the antitumor activity of CPT-11 in vitro and in vivo by inhibiting ABCG2 but not ABCB1: a new clue to circumvent gastrointestinal toxicity risk.Chemotherapy. 2013;59(4):260-72. doi: 10.1159/000357772. Epub 2014 Jan 17.
21 Establishing a relationship between prolactin and altered fatty acid -oxidation via carnitine palmitoyl transferase 1 in breast cancer cells.BMC Cancer. 2011 Feb 4;11:56. doi: 10.1186/1471-2407-11-56.
22 Pharmacological inhibition of carnitine palmitoyltransferase 1 restores mitochondrial oxidative phosphorylation in human trifunctional protein deficient fibroblasts.Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1292-1299. doi: 10.1016/j.bbadis.2017.04.005. Epub 2017 Apr 6.
23 Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model.Clin Cancer Res. 2018 Jun 1;24(11):2585-2593. doi: 10.1158/1078-0432.CCR-17-3811. Epub 2018 Mar 7.
24 Nonalcoholic fatty liver disease does not predict worse perioperative outcomes in bariatric surgery.Obes Res Clin Pract. 2019 Jul-Aug;13(4):416-418. doi: 10.1016/j.orcp.2019.06.006. Epub 2019 Jul 12.
25 Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: A randomised controlled clinical trial.Int J Cardiol. 2018 Nov 15;271:263-268. doi: 10.1016/j.ijcard.2018.05.019. Epub 2018 Aug 1.
26 Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer.Int J Cancer. 2010 Dec 1;127(11):2699-706. doi: 10.1002/ijc.25282.
27 Lentivirus-mediated CTRP6 silencing ameliorates diet-induced obesity in mice.Exp Cell Res. 2018 Jun 1;367(1):15-23. doi: 10.1016/j.yexcr.2018.01.027. Epub 2018 Jan 31.
28 Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade.Oncotarget. 2017 Apr 21;8(34):56051-56065. doi: 10.18632/oncotarget.17359. eCollection 2017 Aug 22.
29 Operative Mortality Prediction for Primary Rectal Cancer: Age Matters.J Am Coll Surg. 2019 Apr;228(4):627-633. doi: 10.1016/j.jamcollsurg.2018.12.014. Epub 2019 Jan 8.
30 Neurophysiological Characterization of Attentional Performance Dysfunction in Schizophrenia Patients in a Reverse-Translated Task.Neuropsychopharmacology. 2017 May;42(6):1338-1348. doi: 10.1038/npp.2016.268. Epub 2016 Dec 5.
31 Banxia Xiexin Decoction Is Effective to Prevent and Control Irinotecan-Induced Delayed Diarrhea in Recurrent Small Cell Lung Cancer.Integr Cancer Ther. 2018 Dec;17(4):1109-1114. doi: 10.1177/1534735418801532. Epub 2018 Sep 19.
32 The 5 choice continuous performance test (5C-CPT): A novel tool to assess cognitive control across species.J Neurosci Methods. 2017 Dec 1;292:53-60. doi: 10.1016/j.jneumeth.2017.07.011. Epub 2017 Jul 25.
33 Lipid-associated metabolic signalling networks in pancreatic beta cell function.Diabetologia. 2020 Jan;63(1):10-20. doi: 10.1007/s00125-019-04976-w. Epub 2019 Aug 19.
34 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
35 Synthesis of Dual Target CPT-Ala-Nor Conjugates and Their Biological Activity Evaluation.Anticancer Agents Med Chem. 2019;19(4):502-508. doi: 10.2174/1871520619666190121121933.
36 Prediction of irinotecan toxicity in metastatic colorectal cancer patients based on machine learning models with pharmacokinetic parameters.J Pharmacol Sci. 2019 May;140(1):20-25. doi: 10.1016/j.jphs.2019.03.004. Epub 2019 May 4.
37 Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma.Gene Ther. 2013 Feb;20(2):143-50. doi: 10.1038/gt.2012.12. Epub 2012 Mar 8.
38 Co-treatment with therapeutic neural stem cells expressing carboxyl esterase and CPT-11 inhibit growth of primary and metastatic lung cancers in mice.Oncotarget. 2014 Dec 30;5(24):12835-48. doi: 10.18632/oncotarget.2547.
39 Gene-specific damage produced by topoisomerase inhibitors in human lung cancer cells and peripheral mononuclear cells as assayed by polymerase chain reaction-stop assay.Anticancer Res. 1998 Sep-Oct;18(5A):3389-93.
40 Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis.J Cyst Fibros. 2018 Mar;17(2):281-285. doi: 10.1016/j.jcf.2017.11.020. Epub 2017 Dec 19.
41 Excipient-free nanodispersion of 7-ethyl-10-hydroxycamptothecin exerts potent therapeutic effects against pancreatic cancer cell lines and patient-derived xenografts.Cancer Lett. 2019 Nov 28;465:36-44. doi: 10.1016/j.canlet.2019.08.019. Epub 2019 Aug 31.
42 AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder.Neuropsychopharmacology. 2011 Nov;36(12):2529-37. doi: 10.1038/npp.2011.141. Epub 2011 Jul 20.
43 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
44 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
45 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
46 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
47 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
48 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
49 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
50 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
51 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
52 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.