Details of the Drug Combination

General Information of Drug Combination (ID: DCUYJY2)

• Drug Combination Name: Vinblastine + Dasatinib
• Indication: Germ cell tumour; Status: Investigative [1]
• Component Drugs:
  Vinblastine (DM5TVS3): Small molecular drug
  Dasatinib (DMJV2EK): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: PA1
  Zero Interaction Potency (ZIP) Score: 0.85
  Bliss Independence Score: 0.93
  Loewe Additivity Score: 0.41
  LHighest Single Agent (HSA) Score: 1.91

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Vinblastine

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Approved	[2]
Anterior urethra cancer	N.A.	Approved	[2]
Extragonadal germ cell tumor	N.A.	Approved	[2]
Gestational trophoblastic neoplasia	2F33-2F76	Approved	[2]
Kaposi sarcoma	2B57	Approved	[2]
Mycosis fungoides	2B01	Approved	[2]
Posterior urethra cancer	N.A.	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Testicular cancer	2C80	Approved	[2]
Testicular germ cell tumor	N.A.	Approved	[2]
Classic Hodgkin lymphoma	N.A.	Investigative	[2]

Vinblastine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Tubulin beta-2 chain (TUBB2)	TTJ2PTI	TBB2A_HUMAN	Inhibitor	[9]

Vinblastine Interacts with 5 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[10]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[11]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[12]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[13]
Multidrug resistance protein 3 (ABCB4)	DTZRMK5	MDR3_HUMAN	Substrate	[14]

Vinblastine Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[15]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[16]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[17]

Vinblastine Interacts with 201 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Response To Substance	[18]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Response To Substance	[19]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Affects Transport	[20]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[21]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)	OT9RDS3H	IKKB_HUMAN	Increases Phosphorylation	[22]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[23]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[24]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Stability	[25]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[26]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Phosphorylation	[27]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Stability	[25]
Integrin alpha-L (ITGAL)	OTCUQAIS	ITAL_HUMAN	Decreases Expression	[26]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Phosphorylation	[22]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[27]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Phosphorylation	[27]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[28]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Affects Localization	[24]
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4)	OTTDCUAO	NFAC4_HUMAN	Decreases Localization	[29]
Transcriptional regulator QRICH1 (QRICH1)	OTPVAX04	QRIC1_HUMAN	Increases Phosphorylation	[30]
Sorting nexin-10 (SNX10)	OT05B7BT	SNX10_HUMAN	Affects Response To Substance	[8]
Histone H1.2 (H1-2)	OT0AVI4M	H12_HUMAN	Affects Response To Substance	[8]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Affects Response To Substance	[8]
Friend leukemia integration 1 transcription factor (FLI1)	OT0EV3LX	FLI1_HUMAN	Affects Response To Substance	[8]
Sulfotransferase 1A1 (SULT1A1)	OT0K7JIE	ST1A1_HUMAN	Affects Response To Substance	[8]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Affects Response To Substance	[8]
DNA polymerase zeta catalytic subunit (REV3L)	OT0OP8EJ	REV3L_HUMAN	Affects Response To Substance	[8]
Rab11 family-interacting protein 1 (RAB11FIP1)	OT0T71OW	RFIP1_HUMAN	Affects Response To Substance	[8]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Affects Response To Substance	[8]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13)	OT0UOKIT	NDUAD_HUMAN	Affects Response To Substance	[8]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[8]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Affects Response To Substance	[8]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Affects Response To Substance	[8]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Response To Substance	[31]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Affects Response To Substance	[8]
m7GpppX diphosphatase (DCPS)	OT1FZVC9	DCPS_HUMAN	Affects Response To Substance	[8]
KN motif and ankyrin repeat domain-containing protein 1 (KANK1)	OT2E7A6W	KANK1_HUMAN	Affects Response To Substance	[8]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Affects Response To Substance	[8]
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25)	OT2MR6O2	SNR25_HUMAN	Affects Response To Substance	[8]
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB)	OT2NHE5E	ODPB_HUMAN	Affects Response To Substance	[8]
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB)	OT2Z03OB	GNPTA_HUMAN	Affects Response To Substance	[8]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Affects Response To Substance	[8]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Affects Response To Substance	[8]
Chromosome-associated kinesin KIF4A (KIF4A)	OT3UWL7D	KIF4A_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)	OT4717TF	NDUB2_HUMAN	Affects Response To Substance	[8]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Affects Response To Substance	[8]
c-Myc-binding protein (MYCBP)	OT4IZR4R	MYCBP_HUMAN	Affects Response To Substance	[8]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Affects Response To Substance	[8]
Transcription termination factor 2 (TTF2)	OT5LJOWM	TTF2_HUMAN	Affects Response To Substance	[8]
Neprilysin (MME)	OT5Q39P8	NEP_HUMAN	Affects Response To Substance	[8]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)	OT6285L4	FKB1A_HUMAN	Affects Response To Substance	[8]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Affects Response To Substance	[8]
Electron transfer flavoprotein subunit beta (ETFB)	OT6Q6FBD	ETFB_HUMAN	Affects Response To Substance	[8]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Affects Response To Substance	[8]
G-protein-signaling modulator 2 (GPSM2)	OT6RPMRM	GPSM2_HUMAN	Affects Response To Substance	[8]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Affects Response To Substance	[8]
CD40 ligand (CD40LG)	OT75Z6A6	CD40L_HUMAN	Decreases Response To Substance	[32]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Affects Response To Substance	[8]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Affects Response To Substance	[8]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Affects Response To Substance	[8]
Pirin (PIR)	OT8ALXHU	PIR_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7)	OT8CV3H5	NDUA7_HUMAN	Affects Response To Substance	[8]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Affects Response To Substance	[8]
Replication protein A 14 kDa subunit (RPA3)	OT8JAQGL	RFA3_HUMAN	Affects Response To Substance	[8]
Deoxyribose-phosphate aldolase (DERA)	OT8SMO3N	DEOC_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase iron-sulfur protein 6, mitochondrial (NDUFS6)	OT9IOONQ	NDUS6_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase 1 subunit C2 (NDUFC2)	OT9M119L	NDUC2_HUMAN	Affects Response To Substance	[8]
Beta-glucuronidase (GUSB)	OT9N1DK3	BGLR_HUMAN	Affects Response To Substance	[8]
Fos-related antigen 1 (FOSL1)	OT9YTYMB	FOSL1_HUMAN	Affects Response To Substance	[8]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)	OTA2TBWS	HMGN3_HUMAN	Affects Response To Substance	[8]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)	OTA6ICI2	NUD4B_HUMAN	Affects Response To Substance	[8]
Cysteine-rich PDZ-binding protein (CRIPT)	OTA6M8M4	CRIPT_HUMAN	Affects Response To Substance	[8]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Affects Response To Substance	[8]
ATP synthase subunit e, mitochondrial (ATP5ME)	OTADVEE2	ATP5I_HUMAN	Affects Response To Substance	[8]
Transmembrane protein 14A (TMEM14A)	OTANQA6G	TM14A_HUMAN	Affects Response To Substance	[8]
MAP kinase-activated protein kinase 5 (MAPKAPK5)	OTAZHPVK	MAPK5_HUMAN	Affects Response To Substance	[8]
Shootin-1 (SHTN1)	OTB07MOG	SHOT1_HUMAN	Affects Response To Substance	[8]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Affects Response To Substance	[8]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Affects Response To Substance	[8]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)	OTB97VIK	IF2B3_HUMAN	Affects Response To Substance	[8]
Membrane-associated progesterone receptor component 1 (PGRMC1)	OTBE6WAC	PGRC1_HUMAN	Affects Response To Substance	[8]
Probable ATP-dependent RNA helicase DDX23 (DDX23)	OTBJHS8C	DDX23_HUMAN	Affects Response To Substance	[8]
Protein FAM3C (FAM3C)	OTBR6U9G	FAM3C_HUMAN	Affects Response To Substance	[8]
Transmembrane protein 134 (TMEM134)	OTBX9H9D	TM134_HUMAN	Affects Response To Substance	[8]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Affects Response To Substance	[8]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Affects Response To Substance	[8]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Affects Response To Substance	[8]
Cytoskeleton-associated protein 2 (CKAP2)	OTCLTC0J	CKAP2_HUMAN	Affects Response To Substance	[8]
Cytochrome c oxidase copper chaperone (COX17)	OTCP4LH2	COX17_HUMAN	Affects Response To Substance	[8]
Tetraspanin-13 (TSPAN13)	OTCS9BZY	TSN13_HUMAN	Affects Response To Substance	[8]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Affects Response To Substance	[8]
Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1)	OTDCSPXH	SUCA_HUMAN	Affects Response To Substance	[8]
Proteasome activator complex subunit 4 (PSME4)	OTDGF53O	PSME4_HUMAN	Affects Response To Substance	[8]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Affects Response To Substance	[8]
Superkiller complex protein 8 (SKIC8)	OTDSQYDN	SKI8_HUMAN	Affects Response To Substance	[8]
Dickkopf-related protein 3 (DKK3)	OTDU94EY	DKK3_HUMAN	Affects Response To Substance	[8]
Geminin (GMNN)	OTDYKNIY	GEMI_HUMAN	Affects Response To Substance	[8]
EF-hand calcium-binding domain-containing protein 7 (EFCAB7)	OTE0EG10	EFCB7_HUMAN	Affects Response To Substance	[8]
Vitamin K-dependent gamma-carboxylase (GGCX)	OTE0FNAP	VKGC_HUMAN	Affects Response To Substance	[8]
ATP synthase subunit f, mitochondrial (ATP5MF)	OTE4TBG9	ATPK_HUMAN	Affects Response To Substance	[8]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Affects Response To Substance	[8]
Protein pelota homolog (PELO)	OTF3WLIM	PELO_HUMAN	Affects Response To Substance	[8]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Affects Response To Substance	[8]
Sortilin (SORT1)	OTFCQ4B1	SORT_HUMAN	Affects Response To Substance	[8]
Exosome complex component RRP45 (EXOSC9)	OTFKB37F	EXOS9_HUMAN	Affects Response To Substance	[8]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Affects Response To Substance	[8]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Affects Response To Substance	[8]
Phospholipid-transporting ATPase ABCA3 (ABCA3)	OTH6MSKQ	ABCA3_HUMAN	Decreases Response To Substance	[33]
Sigma intracellular receptor 2 (TMEM97)	OTH76ZWK	SGMR2_HUMAN	Affects Response To Substance	[8]
Transmembrane protein 156 (TMEM156)	OTH7YJID	TM156_HUMAN	Affects Response To Substance	[8]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Affects Response To Substance	[8]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Affects Response To Substance	[8]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Affects Response To Substance	[8]
Kinesin-like protein KIF11 (KIF11)	OTHRGLCQ	KIF11_HUMAN	Affects Response To Substance	[8]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Affects Response To Substance	[8]
U6 snRNA-associated Sm-like protein LSm7 (LSM7)	OTHZ2XPX	LSM7_HUMAN	Affects Response To Substance	[8]
Kinesin-like protein KIF1B (KIF1B)	OTI1XQTO	KIF1B_HUMAN	Affects Response To Substance	[8]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Affects Response To Substance	[8]
Protein Mis18-beta (OIP5)	OTI5C2DE	MS18B_HUMAN	Affects Response To Substance	[8]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Affects Response To Substance	[8]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Affects Response To Substance	[8]
Baculoviral IAP repeat-containing protein 7 (BIRC7)	OTITCGHB	BIRC7_HUMAN	Decreases Response To Substance	[34]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1)	OTJ5TNHB	NDUC1_HUMAN	Affects Response To Substance	[8]
Low molecular weight phosphotyrosine protein phosphatase (ACP1)	OTJ9CKLU	PPAC_HUMAN	Affects Response To Substance	[8]
G/T mismatch-specific thymine DNA glycosylase (TDG)	OTJB0YIH	TDG_HUMAN	Affects Response To Substance	[8]
E3 ubiquitin-protein ligase FANCL (FANCL)	OTJC7QPQ	FANCL_HUMAN	Affects Response To Substance	[8]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Affects Response To Substance	[8]
Lysophosphatidic acid receptor 1 (LPAR1)	OTJNJQPF	LPAR1_HUMAN	Affects Response To Substance	[8]
Kinesin-like protein KIF15 (KIF15)	OTJRJEXL	KIF15_HUMAN	Affects Response To Substance	[8]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Affects Response To Substance	[8]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Affects Response To Substance	[8]
Gamma-glutamylcyclotransferase (GGCT)	OTKAICP5	GGCT_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase 1 alpha subcomplex subunit 1 (NDUFA1)	OTKBUQXP	NDUA1_HUMAN	Affects Response To Substance	[8]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Affects Response To Substance	[8]
Sideroflexin-1 (SFXN1)	OTL66767	SFXN1_HUMAN	Affects Response To Substance	[8]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Affects Response To Substance	[8]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Increases Response To Substance	[31]
Striatin (STRN)	OTLOZL5I	STRN_HUMAN	Affects Response To Substance	[8]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLA2)	OTMZD4PW	SUCB1_HUMAN	Affects Response To Substance	[8]
Protein downstream neighbor of Son (DONSON)	OTN5HE0W	DONS_HUMAN	Affects Response To Substance	[8]
Cytochrome c oxidase subunit 6B1 (COX6B1)	OTNKXYQI	CX6B1_HUMAN	Affects Response To Substance	[8]
Keratinocyte-associated transmembrane protein 2 (C5ORF15)	OTO126A1	KCT2_HUMAN	Affects Response To Substance	[8]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Affects Response To Substance	[35]
tRNA (TRMT5)	OTOAZBPD	TRM5_HUMAN	Affects Response To Substance	[8]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Affects Response To Substance	[8]
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A)	OTP0961M	COX5A_HUMAN	Affects Response To Substance	[8]
DNA fragmentation factor subunit beta (DFFB)	OTPBW5N5	DFFB_HUMAN	Affects Response To Substance	[8]
Interleukin-13 receptor subunit alpha-2 (IL13RA2)	OTPC2G0X	I13R2_HUMAN	Affects Response To Substance	[8]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Affects Response To Substance	[8]
Kazrin (KAZN)	OTPM7BYM	KAZRN_HUMAN	Affects Response To Substance	[8]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Affects Response To Substance	[8]
Prostaglandin E synthase 3 (PTGES3)	OTPPQWI0	TEBP_HUMAN	Affects Response To Substance	[8]
Epithelial membrane protein 2 (EMP2)	OTPS2H0L	EMP2_HUMAN	Affects Response To Substance	[8]
Ornithine decarboxylase antizyme 1 (OAZ1)	OTPT0PKZ	OAZ1_HUMAN	Affects Response To Substance	[8]
Sister chromatid cohesion protein DCC1 (DSCC1)	OTPUVLZT	DCC1_HUMAN	Affects Response To Substance	[8]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Affects Response To Substance	[36]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Affects Response To Substance	[8]
Ran-specific GTPase-activating protein (RANBP1)	OTQE226K	RANG_HUMAN	Affects Response To Substance	[8]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Affects Response To Substance	[8]
MAPK/MAK/MRK overlapping kinase (MOK)	OTQK7M9V	MOK_HUMAN	Affects Response To Substance	[8]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)	OTQRET2B	S5A1_HUMAN	Affects Response To Substance	[8]
Solute carrier family 22 member 3 (SLC22A3)	OTQYGVXX	S22A3_HUMAN	Affects Response To Substance	[8]
Large ribosomal subunit protein mL63 (MRPL57)	OTRB659E	RT63_HUMAN	Affects Response To Substance	[8]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Affects Response To Substance	[8]
Olfactory receptor 1I1 (OR1I1)	OTRFD8BH	OR1I1_HUMAN	Affects Response To Substance	[8]
Protein CREG1 (CREG1)	OTRHJ8HK	CREG1_HUMAN	Affects Response To Substance	[8]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Affects Response To Substance	[8]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Affects Response To Substance	[8]
Latent-transforming growth factor beta-binding protein 2 (LTBP2)	OTS88GSD	LTBP2_HUMAN	Affects Response To Substance	[8]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Affects Response To Substance	[8]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Affects Response To Substance	[8]
Leucine-rich repeat-containing protein 1 (LRRC1)	OTSVD30Q	LRRC1_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2)	OTSZF7D6	NDUV2_HUMAN	Affects Response To Substance	[8]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Affects Response To Substance	[8]
Rho GTPase-activating protein SYDE1 (SYDE1)	OTTIAF4D	SYDE1_HUMAN	Affects Response To Substance	[8]
Isocitrate dehydrogenase , mitochondrial (IDH2)	OTTQA4PB	IDHP_HUMAN	Affects Response To Substance	[8]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Affects Response To Substance	[8]
General transcription factor II-I (GTF2I)	OTUYL1TQ	GTF2I_HUMAN	Affects Response To Substance	[8]
Integrin beta-1-binding protein 1 (ITGB1BP1)	OTVQFNGS	ITBP1_HUMAN	Affects Response To Substance	[8]
Transcription factor IIIA (GTF3A)	OTVROUVQ	TF3A_HUMAN	Affects Response To Substance	[8]
ATP-binding cassette sub-family A member 2 (ABCA2)	OTVSYK0X	ABCA2_HUMAN	Decreases Response To Substance	[33]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Affects Response To Substance	[8]
Serine/threonine-protein kinase 26 (STK26)	OTW4QE0D	STK26_HUMAN	Affects Response To Substance	[8]
Homer protein homolog 1 (HOMER1)	OTWFD3SI	HOME1_HUMAN	Affects Response To Substance	[8]
Acyl-coenzyme A thioesterase 13 (ACOT13)	OTWRUST1	ACO13_HUMAN	Affects Response To Substance	[8]
Divergent protein kinase domain 1A (DIPK1A)	OTWS5V2I	DIK1A_HUMAN	Affects Response To Substance	[8]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Affects Response To Substance	[8]
Hematopoietic lineage cell-specific protein (HCLS1)	OTX7WGYN	HCLS1_HUMAN	Affects Response To Substance	[8]
Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)	OTX8SZOT	NUD15_HUMAN	Affects Response To Substance	[8]
NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3)	OTXL10N9	NDUA3_HUMAN	Affects Response To Substance	[8]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Affects Response To Substance	[8]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Affects Response To Substance	[8]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Affects Response To Substance	[8]
Kinesin-like protein KIF23 (KIF23)	OTY850JC	KIF23_HUMAN	Affects Response To Substance	[8]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Affects Response To Substance	[8]
Proteasome subunit beta type-1 (PSMB1)	OTYRFBAH	PSB1_HUMAN	Affects Response To Substance	[8]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Affects Response To Substance	[8]
G-protein coupled receptor 176 (GPR176)	OTZ8PL9B	GP176_HUMAN	Affects Response To Substance	[8]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Affects Response To Substance	[8]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Affects Response To Substance	[8]

Indication(s) of Dasatinib

Disease Entry	ICD 11	Status	REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive	N.A.	Approved	[4]
Brain disease	8C70-8E61	Approved	[4]
Central nervous system disease	8A04-8D87	Approved	[4]
Chronic myelogenous leukaemia	2A20.0	Approved	[5]
Chronic myeloid leukaemia	2A20	Approved	[6]
Glioblastoma	2A00	Approved	[4]
Leukemia	N.A.	Approved	[4]
Lung cancer	2C25.0	Approved	[4]
Non-small-cell lung cancer	2C25.Y	Approved	[4]
Plasma cell myeloma	2A83.1	Approved	[4]
Multiple myeloma	2A83	Phase 2	[5]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[7]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[7]

Dasatinib Interacts with 5 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[40]
Fyn tyrosine protein kinase (FYN)	TT2B9KF	FYN_HUMAN	Inhibitor	[40]
Fusion protein Bcr-Abl (Bcr-Abl)	TTS7G69	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[40]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[40]
HUMAN fusion protein Bcr-Abl (Bcr-Abl)	TTE63HY	BCR_HUMAN/ABL1_HUMAN	Inhibitor	[7]

Dasatinib Interacts with 4 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[41]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[42]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[43]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[43]

Dasatinib Interacts with 4 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[44]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[44]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[44]
Dimethylaniline oxidase 3 (FMO3)	DEP76YL	FMO3_HUMAN	Metabolism	[45]

Dasatinib Interacts with 453 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Binding	[37]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)	OTB6YLFT	ENPP3_HUMAN	Decreases Expression	[37]
Tyrosine-protein kinase HCK (HCK)	OTRL6OSI	HCK_HUMAN	Decreases Phosphorylation	[37]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Decreases Expression	[37]
Tyrosine-protein kinase Fgr (FGR)	OTCUYU9F	FGR_HUMAN	Affects Binding	[37]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Affects Binding	[37]
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Decreases Expression	[37]
Tyrosine-protein kinase CSK (CSK)	OTP03OD0	CSK_HUMAN	Affects Binding	[37]
Tyrosine-protein kinase Tec (TEC)	OTU6QJAJ	TEC_HUMAN	Affects Binding	[37]
Tyrosine-protein kinase FRK (FRK)	OTEKV1SC	FRK_HUMAN	Affects Binding	[37]
Ephrin type-A receptor 5 (EPHA5)	OTAM0CVX	EPHA5_HUMAN	Affects Binding	[37]
Ephrin type-B receptor 4 (EPHB4)	OTKLPVXJ	EPHB4_HUMAN	Affects Binding	[37]
Sialomucin core protein 24 (CD164)	OTZ7FIU8	MUC24_HUMAN	Decreases Expression	[37]
Amidophosphoribosyltransferase (PPAT)	OTXK12ZB	PUR1_HUMAN	Affects Binding	[37]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Affects Binding	[37]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)	OT0ALMEG	M3K20_HUMAN	Affects Binding	[37]
ATP-dependent RNA helicase DDX39A (DDX39A)	OT0Z6E1K	DX39A_HUMAN	Decreases Expression	[38]
Cell division cycle 7-related protein kinase (CDC7)	OT5133XY	CDC7_HUMAN	Decreases Expression	[38]
Serine/threonine-protein kinase PLK4 (PLK4)	OTV8KZDZ	PLK4_HUMAN	Decreases Expression	[38]
Nuclear envelope integral membrane protein 1 (NEMP1)	OTWN3S47	NEMP1_HUMAN	Decreases Expression	[38]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Decreases Expression	[38]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[38]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Decreases Expression	[38]
Fanconi anemia group A protein (FANCA)	OTPEFJD4	FANCA_HUMAN	Decreases Expression	[38]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[38]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Decreases Expression	[38]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[38]
Protein sprouty homolog 2 (SPRY2)	OTH0CRCZ	SPY2_HUMAN	Decreases Expression	[38]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[38]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[38]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)	OTDVVNS0	EDIL3_HUMAN	Increases Expression	[38]
NUAK family SNF1-like kinase 1 (NUAK1)	OTLLHJJQ	NUAK1_HUMAN	Increases Expression	[38]
Neuropilin-2 (NRP2)	OTZL256E	NRP2_HUMAN	Increases Expression	[38]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[38]
Tetraspanin-2 (TSPAN2)	OTTDPQF1	TSN2_HUMAN	Increases Expression	[38]
Leupaxin (LPXN)	OTUNV3CK	LPXN_HUMAN	Decreases Expression	[38]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[38]
DNA polymerase theta (POLQ)	OTBHK0E6	DPOLQ_HUMAN	Decreases Expression	[38]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Decreases Expression	[38]
Glypican-4 (GPC4)	OTUJ14DW	GPC4_HUMAN	Increases Expression	[38]
Serpin B7 (SERPINB7)	OTZ95LR2	SPB7_HUMAN	Decreases Expression	[38]
Transient receptor potential cation channel subfamily A member 1 (TRPA1)	OTRDIR5M	TRPA1_HUMAN	Decreases Expression	[38]
Ribonuclease H2 subunit A (RNASEH2A)	OT8G3G7K	RNH2A_HUMAN	Decreases Expression	[38]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[38]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Decreases Expression	[38]
Centrosomal protein of 152 kDa (CEP152)	OTOKZR9B	CE152_HUMAN	Decreases Expression	[38]
Potassium channel subfamily K member 2 (KCNK2)	OTWBT8MG	KCNK2_HUMAN	Decreases Expression	[38]
Chromosome-associated kinesin KIF4A (KIF4A)	OT3UWL7D	KIF4A_HUMAN	Decreases Expression	[38]
Structural maintenance of chromosomes protein 2 (SMC2)	OT5S0DV4	SMC2_HUMAN	Decreases Expression	[38]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Increases Expression	[38]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)	OT9QIHEQ	RECK_HUMAN	Increases Expression	[38]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Decreases Expression	[38]
Histone-lysine N-methyltransferase NSD2 (NSD2)	OTQ6SW4R	NSD2_HUMAN	Decreases Expression	[38]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Increases Expression	[38]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Decreases Expression	[38]
Complement C1r subcomponent (C1R)	OTA0ZNIU	C1R_HUMAN	Increases Expression	[38]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[38]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Increases Expression	[38]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Increases Expression	[38]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Increases Expression	[38]
Collagen alpha-1(IV) chain (COL4A1)	OTL6D1YE	CO4A1_HUMAN	Increases Expression	[38]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Increases Expression	[38]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Decreases Expression	[38]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[38]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Increases Expression	[38]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Decreases Expression	[38]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[38]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[38]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Increases Expression	[38]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Expression	[38]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Decreases Expression	[38]
Laminin subunit beta-1 (LAMB1)	OT6J9LJR	LAMB1_HUMAN	Increases Expression	[38]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Increases Expression	[38]
Matrix Gla protein (MGP)	OTZWU3FU	MGP_HUMAN	Increases Expression	[38]
Collagen alpha-2(IV) chain (COL4A2)	OTJK1LKN	CO4A2_HUMAN	Increases Expression	[38]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Increases Expression	[38]
Complement C1s subcomponent (C1S)	OTCIZU2A	C1S_HUMAN	Increases Expression	[38]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[38]
Histone H2A.Z (H2AZ1)	OT3KJJNQ	H2AZ_HUMAN	Decreases Expression	[38]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Decreases Expression	[38]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Decreases Expression	[38]
Histone H1.4 (H1-4)	OTQ450A3	H14_HUMAN	Decreases Expression	[38]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[38]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[38]
Fibroblast growth factor 5 (FGF5)	OTQXGHBY	FGF5_HUMAN	Decreases Expression	[38]
Collagen alpha-1(XI) chain (COL11A1)	OTB0DRMS	COBA1_HUMAN	Increases Expression	[38]
Elastin (ELN)	OTFSO7PG	ELN_HUMAN	Increases Expression	[38]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Increases Expression	[38]
Histone H1.5 (H1-5)	OTAN7RD9	H15_HUMAN	Decreases Expression	[38]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Decreases Expression	[38]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Decreases Expression	[38]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Increases Expression	[38]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)	OT3MPPYX	ENPP1_HUMAN	Decreases Expression	[38]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Expression	[38]
Integrin alpha-6 (ITGA6)	OT3FA39C	ITA6_HUMAN	Decreases Expression	[38]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Decreases Expression	[38]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[38]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[38]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[38]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Decreases Expression	[38]
Cardiac phospholamban (PLN)	OTT3RRJN	PPLA_HUMAN	Increases Expression	[38]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Decreases Expression	[38]
Dipeptidyl peptidase 4 (DPP4)	OT16MVL9	DPP4_HUMAN	Increases Expression	[38]
Leiomodin-1 (LMOD1)	OTZ2MEMG	LMOD1_HUMAN	Increases Expression	[38]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[38]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Decreases Expression	[38]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[38]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Increases Expression	[38]
Sodium- and chloride-dependent taurine transporter (SLC6A6)	OT67U7G3	SC6A6_HUMAN	Increases Expression	[38]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[38]
Histone H2B type 1-B (H2BC3)	OT1BLFJO	H2B1B_HUMAN	Decreases Expression	[38]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[38]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[38]
Syndecan-2 (SDC2)	OTEEHY1D	SDC2_HUMAN	Increases Expression	[38]
Replication factor C subunit 4 (RFC4)	OTWALD2R	RFC4_HUMAN	Decreases Expression	[38]
Replication factor C subunit 2 (RFC2)	OTJ9N6BD	RFC2_HUMAN	Decreases Expression	[38]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Increases Expression	[38]
Myosin-10 (MYH10)	OTXN2WXS	MYH10_HUMAN	Increases Expression	[38]
Myosin-11 (MYH11)	OTVNVWY3	MYH11_HUMAN	Increases Expression	[38]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Increases Expression	[38]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[38]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Decreases Expression	[38]
Nicotinamide N-methyltransferase (NNMT)	OTFM38GU	NNMT_HUMAN	Increases Expression	[38]
Pre-B-cell leukemia transcription factor 1 (PBX1)	OTORABGO	PBX1_HUMAN	Increases Expression	[38]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Decreases Expression	[38]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Decreases Expression	[38]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Increases Expression	[38]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[38]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[38]
Condensin-2 complex subunit D3 (NCAPD3)	OTOZY2UL	CNDD3_HUMAN	Decreases Expression	[38]
Neutral amino acid transporter A (SLC1A4)	OTVODHAE	SATT_HUMAN	Increases Expression	[38]
Cell surface glycoprotein MUC18 (MCAM)	OTT8XKGE	MUC18_HUMAN	Increases Expression	[38]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[38]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[38]
Glutathione S-transferase Mu 5 (GSTM5)	OTMMBFY8	GSTM5_HUMAN	Increases Expression	[38]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Decreases Expression	[38]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[38]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Decreases Expression	[38]
DNA primase large subunit (PRIM2)	OTGT0KTF	PRI2_HUMAN	Decreases Expression	[38]
Thrombospondin-3 (THBS3)	OTDKMUBD	TSP3_HUMAN	Increases Expression	[38]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[38]
Selenoprotein P (SELENOP)	OT02B8IR	SEPP1_HUMAN	Increases Expression	[38]
Kinetochore-associated protein 1 (KNTC1)	OTI2OOFN	KNTC1_HUMAN	Decreases Expression	[38]
Ras association domain-containing protein 2 (RASSF2)	OT2JHDO4	RASF2_HUMAN	Increases Expression	[38]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)	OT4DJFFU	DNA2_HUMAN	Decreases Expression	[38]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[38]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Increases Expression	[38]
Calponin-1 (CNN1)	OTVPG39Z	CNN1_HUMAN	Increases Expression	[38]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[38]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Decreases Expression	[38]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Decreases Expression	[38]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[38]
Microfibril-associated glycoprotein 4 (MFAP4)	OT5W64QY	MFAP4_HUMAN	Increases Expression	[38]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Decreases Expression	[38]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B)	OTNUPLUJ	CKS1_HUMAN	Decreases Expression	[38]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Expression	[38]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Increases Expression	[38]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Increases Expression	[38]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Increases Expression	[38]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Increases Expression	[38]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Increases Expression	[38]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Decreases Expression	[38]
Kinesin-like protein KIF23 (KIF23)	OTY850JC	KIF23_HUMAN	Decreases Expression	[38]
Histone H1.1 (H1-1)	OTSS815G	H11_HUMAN	Decreases Expression	[38]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Decreases Expression	[38]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Decreases Expression	[38]
Transcription factor SOX-4 (SOX4)	OTSS40SS	SOX4_HUMAN	Increases Expression	[38]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Increases Expression	[38]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[38]
Lactadherin (MFGE8)	OTQKE41R	MFGM_HUMAN	Increases Expression	[38]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Increases Expression	[38]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Decreases Expression	[38]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)	OTA0UNHM	ECH1_HUMAN	Increases Expression	[38]
MAL-like protein (MALL)	OTKGZ89D	MALL_HUMAN	Decreases Expression	[38]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[38]
Centromere protein R (ITGB3BP)	OT6Q7GR3	CENPR_HUMAN	Decreases Expression	[38]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Decreases Expression	[38]
Limbic system-associated membrane protein (LSAMP)	OTYXVQX2	LSAMP_HUMAN	Increases Expression	[38]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Increases Expression	[38]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)	OT6KFNMS	CAC1C_HUMAN	Increases Expression	[38]
DNA polymerase alpha subunit B (POLA2)	OTTWQ73N	DPOA2_HUMAN	Decreases Expression	[38]
Fibroleukin (FGL2)	OT8M3H72	FGL2_HUMAN	Increases Expression	[38]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)	OTKUW1WT	PDE3A_HUMAN	Increases Expression	[38]
Semaphorin-3A (SEMA3A)	OTQJSV7W	SEM3A_HUMAN	Decreases Expression	[38]
DNA replication licensing factor MCM6 (MCM6)	OTKLIAWT	MCM6_HUMAN	Decreases Expression	[38]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)	OTX7MWW1	ITPR1_HUMAN	Increases Expression	[38]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Decreases Expression	[38]
DNA replication complex GINS protein PSF1 (GINS1)	OTVQZMMQ	PSF1_HUMAN	Decreases Expression	[38]
Transmembrane glycoprotein NMB (GPNMB)	OTB7KQKV	GPNMB_HUMAN	Increases Expression	[38]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Decreases Expression	[38]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[38]
Condensin complex subunit 1 (NCAPD2)	OT8VGE2O	CND1_HUMAN	Decreases Expression	[38]
Disks large-associated protein 5 (DLGAP5)	OTWCN39U	DLGP5_HUMAN	Decreases Expression	[38]
SCL-interrupting locus protein (STIL)	OT9799VN	STIL_HUMAN	Decreases Expression	[38]
Pachytene checkpoint protein 2 homolog (TRIP13)	OTFM3TI9	PCH2_HUMAN	Decreases Expression	[38]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Increases Expression	[38]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Decreases Expression	[38]
Insulin-like growth factor-binding protein 7 (IGFBP7)	OT1D416P	IBP7_HUMAN	Increases Expression	[38]
Neuronal regeneration-related protein (NREP)	OT2AZPKK	NREP_HUMAN	Increases Expression	[38]
Prostacyclin synthase (PTGIS)	OTT3RW6N	PTGIS_HUMAN	Increases Expression	[38]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[38]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[38]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)	OTJ8LX4N	PCKGM_HUMAN	Increases Expression	[38]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Increases Expression	[38]
Flap endonuclease GEN homolog 1 (GEN1)	OT1XFQXF	GEN_HUMAN	Decreases Expression	[38]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)	OTCH86VF	AL1L2_HUMAN	Increases Expression	[38]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)	OTOBICRD	SVEP1_HUMAN	Increases Expression	[38]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[38]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Increases Expression	[38]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Decreases Expression	[38]
Centromere protein W (CENPW)	OTZL05QN	CENPW_HUMAN	Decreases Expression	[38]
Shugoshin 1 (SGO1)	OTIP6IRN	SGO1_HUMAN	Decreases Expression	[38]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4)	OTU4DSDE	HERC4_HUMAN	Decreases Expression	[38]
Testis-expressed protein 30 (TEX30)	OT87WEPQ	TEX30_HUMAN	Decreases Expression	[38]
DEP domain-containing protein 1A (DEPDC1)	OT0JWE1B	DEP1A_HUMAN	Decreases Expression	[38]
Tensin-3 (TNS3)	OTPG2D8Z	TENS3_HUMAN	Increases Expression	[38]
Cell division cycle-associated protein 2 (CDCA2)	OTX8UF9J	CDCA2_HUMAN	Decreases Expression	[38]
Protein FAM72D (FAM72D)	OTCQVOXB	FA72D_HUMAN	Decreases Expression	[38]
Repulsive guidance molecule B (RGMB)	OT2DROYU	RGMB_HUMAN	Decreases Expression	[38]
STEAP family member 1B (STEAP1B)	OTZJDFWK	STEAL_HUMAN	Decreases Expression	[38]
Mis18-binding protein 1 (MIS18BP1)	OT41T0FB	M18BP_HUMAN	Decreases Expression	[38]
Mitochondrial fission regulator 2 (MTFR2)	OTLOR68D	MTFR2_HUMAN	Decreases Expression	[38]
Rho GTPase-activating protein 11A (ARHGAP11A)	OTVQCFVP	RHGBA_HUMAN	Decreases Expression	[38]
E3 ubiquitin-protein ligase RFWD3 (RFWD3)	OTDUULBQ	RFWD3_HUMAN	Decreases Expression	[38]
Podocan-like protein 1 (PODNL1)	OTL72ES9	PONL1_HUMAN	Increases Expression	[38]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[38]
Neutral cholesterol ester hydrolase 1 (NCEH1)	OTZ66CKX	NCEH1_HUMAN	Decreases Expression	[38]
Fidgetin-like protein 1 (FIGNL1)	OTKII63K	FIGL1_HUMAN	Decreases Expression	[38]
ATPase family AAA domain-containing protein 2 (ATAD2)	OT8MCRNY	ATAD2_HUMAN	Decreases Expression	[38]
Serine protease FAM111B (FAM111B)	OT9IQ9NV	F111B_HUMAN	Decreases Expression	[38]
Protein FAM180A (FAM180A)	OTKQ7XUG	F180A_HUMAN	Decreases Expression	[38]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Increases Expression	[38]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Increases Expression	[38]
ALK and LTK ligand 1 (ALKAL1)	OTZGAZ79	ALKL1_HUMAN	Increases Expression	[38]
Protein MMS22-like (MMS22L)	OTJI0HM9	MMS22_HUMAN	Decreases Expression	[38]
Centrosomal protein of 128 kDa (CEP128)	OT922YCJ	CE128_HUMAN	Decreases Expression	[38]
DNA-binding protein RFX8 (RFX8)	OT27SFGQ	RFX8_HUMAN	Decreases Expression	[38]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Decreases Expression	[38]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Decreases Expression	[38]
Treslin (TICRR)	OT2HKWOC	TICRR_HUMAN	Decreases Expression	[38]
MAM domain-containing protein 2 (MAMDC2)	OT4GICNY	MAMC2_HUMAN	Increases Expression	[38]
LisH domain-containing protein ARMC9 (ARMC9)	OT0MZER2	ARMC9_HUMAN	Increases Expression	[38]
Rho GTPase-activating protein 22 (ARHGAP22)	OTXUQEFL	RHG22_HUMAN	Decreases Expression	[38]
Podocan (PODN)	OTV3P7P5	PODN_HUMAN	Increases Expression	[38]
Schlafen family member 11 (SLFN11)	OTJWFPMY	SLN11_HUMAN	Decreases Expression	[38]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Increases Expression	[38]
Alpha-protein kinase 2 (ALPK2)	OTWZZDQ9	ALPK2_HUMAN	Increases Expression	[38]
Myopalladin (MYPN)	OTHTOFDU	MYPN_HUMAN	Decreases Expression	[38]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)	OT89V4N5	MARH3_HUMAN	Decreases Expression	[38]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3)	OT4RZV2M	IQGA3_HUMAN	Decreases Expression	[38]
Condensin-2 complex subunit G2 (NCAPG2)	OTZYENKO	CNDG2_HUMAN	Decreases Expression	[38]
GAS2-like protein 3 (GAS2L3)	OTWPVI29	GA2L3_HUMAN	Decreases Expression	[38]
Histone H2A type 2-B (H2AC21)	OTH7W2NJ	H2A2B_HUMAN	Decreases Expression	[38]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2)	OT3TK3NN	PKHH2_HUMAN	Increases Expression	[38]
Extracellular sulfatase Sulf-2 (SULF2)	OTIXMUVL	SULF2_HUMAN	Increases Expression	[38]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Increases Expression	[38]
CD302 antigen (CD302)	OTX580VU	CD302_HUMAN	Increases Expression	[38]
Spindle and kinetochore-associated protein 3 (SKA3)	OTLHEVJD	SKA3_HUMAN	Decreases Expression	[38]
DNA damage-induced apoptosis suppressor protein (DDIAS)	OTTGG2PM	DDIAS_HUMAN	Decreases Expression	[38]
Cytoskeleton-associated protein 2-like (CKAP2L)	OT4T73GG	CKP2L_HUMAN	Decreases Expression	[38]
Fanconi anemia group M protein (FANCM)	OTNJG99Z	FANCM_HUMAN	Decreases Expression	[38]
Lung adenoma susceptibility protein 2 (C18ORF54)	OT4WJKTF	LAS2_HUMAN	Decreases Expression	[38]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Decreases Expression	[38]
Retinol dehydrogenase 10 (RDH10)	OTL9FSGF	RDH10_HUMAN	Increases Expression	[38]
Centromere protein L (CENPL)	OT7P006B	CENPL_HUMAN	Decreases Expression	[38]
Rho GTPase-activating protein 18 (ARHGAP18)	OTYMJP6H	RHG18_HUMAN	Decreases Expression	[38]
T-complex protein 11-like protein 2 (TCP11L2)	OTTIZO7B	T11L2_HUMAN	Increases Expression	[38]
Aminopeptidase O (AOPEP)	OT0MMANL	AMPO_HUMAN	Increases Expression	[38]
Junction-mediating and -regulatory protein (JMY)	OTH5FFVK	JMY_HUMAN	Increases Expression	[38]
Holliday junction recognition protein (HJURP)	OTWMV16B	HJURP_HUMAN	Decreases Expression	[38]
SHC SH2 domain-binding protein 1 (SHCBP1)	OT3A21CM	SHCBP_HUMAN	Decreases Expression	[38]
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1)	OTVXEF85	MDGA1_HUMAN	Increases Expression	[38]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Increases Expression	[38]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[38]
Protein CIP2A (CIP2A)	OTVS2GXA	CIP2A_HUMAN	Decreases Expression	[38]
Sodium-dependent phosphate transporter 1 (SLC20A1)	OTC3D894	S20A1_HUMAN	Decreases Expression	[38]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Decreases Expression	[38]
Basic helix-loop-helix ARNT-like protein 2 (BMAL2)	OTIBDGQC	BMAL2_HUMAN	Decreases Expression	[38]
Centromere protein I (CENPI)	OTWRIMZ3	CENPI_HUMAN	Decreases Expression	[38]
Serine protease HTRA1 (HTRA1)	OTR8ACBF	HTRA1_HUMAN	Increases Expression	[38]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Decreases Expression	[38]
Neogenin (NEO1)	OTGJ1997	NEO1_HUMAN	Increases Expression	[38]
Histone H2B type 1-H (H2BC9)	OTQ9XX72	H2B1H_HUMAN	Decreases Expression	[38]
F-box only protein 32 (FBXO32)	OTUE978R	FBX32_HUMAN	Increases Expression	[38]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[38]
Transcription factor E2F7 (E2F7)	OTWW358N	E2F7_HUMAN	Decreases Expression	[38]
Spindle and kinetochore-associated protein 1 (SKA1)	OTDYJ12A	SKA1_HUMAN	Decreases Expression	[38]
Mdm2-binding protein (MTBP)	OTWLCW9C	MTBP_HUMAN	Decreases Expression	[38]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Decreases Expression	[38]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[38]
Serine/threonine-protein kinase greatwall (MASTL)	OTQ7YKK5	GWL_HUMAN	Decreases Expression	[38]
Centromere protein N (CENPN)	OTRO7XPD	CENPN_HUMAN	Decreases Expression	[38]
Proline-rich protein 11 (PRR11)	OT2JJ08Z	PRR11_HUMAN	Decreases Expression	[38]
Lymphokine-activated killer T-cell-originated protein kinase (PBK)	OT5Z27TW	TOPK_HUMAN	Decreases Expression	[38]
Leucine-rich repeat protein 1 (LRR1)	OTSWDXVY	LLR1_HUMAN	Decreases Expression	[38]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1)	OT5TS6P7	PCMD1_HUMAN	Increases Expression	[38]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)	OTB71I02	DCBD2_HUMAN	Decreases Expression	[38]
Kinesin-like protein KIF20B (KIF20B)	OTS68AHH	KI20B_HUMAN	Decreases Expression	[38]
ATPase family AAA domain-containing protein 5 (ATAD5)	OTI8ABKF	ATAD5_HUMAN	Decreases Expression	[38]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Expression	[38]
Hyaluronan and proteoglycan link protein 3 (HAPLN3)	OTB853Z1	HPLN3_HUMAN	Increases Expression	[38]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Decreases Expression	[38]
Cell division cycle-associated protein 3 (CDCA3)	OTUI8QK3	CDCA3_HUMAN	Decreases Expression	[38]
Kinesin-like protein KIF2C (KIF2C)	OTJ8G3NP	KIF2C_HUMAN	Decreases Expression	[38]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[38]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[38]
Histone H2B type 1-M (H2BC14)	OTSDZZZY	H2B1M_HUMAN	Decreases Expression	[38]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Decreases Expression	[38]
Mitochondrial genome maintenance exonuclease 1 (MGME1)	OTC5LPXX	MGME1_HUMAN	Decreases Expression	[38]
Synaptotagmin-15 (SYT15)	OT7Q088G	SYT15_HUMAN	Increases Expression	[38]
Hephaestin (HEPH)	OTZ2F15Z	HEPH_HUMAN	Increases Expression	[38]
DNA replication complex GINS protein SLD5 (GINS4)	OTCVOO3S	SLD5_HUMAN	Decreases Expression	[38]
Centromere protein K (CENPK)	OTKPUF8K	CENPK_HUMAN	Decreases Expression	[38]
Protein PIMREG (PIMREG)	OTKC8T3E	PIMRE_HUMAN	Decreases Expression	[38]
Nucleoporin NDC1 (NDC1)	OTF2GQC1	NDC1_HUMAN	Decreases Expression	[38]
Centromere protein O (CENPO)	OTXAH83Y	CENPO_HUMAN	Decreases Expression	[38]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[38]
TIMELESS-interacting protein (TIPIN)	OT9PZHXV	TIPIN_HUMAN	Decreases Expression	[38]
Kinesin-like protein KIFC1 (KIFC1)	OTNQDS00	KIFC1_HUMAN	Decreases Expression	[38]
Meiotic nuclear division protein 1 homolog (MND1)	OTS87F3H	MND1_HUMAN	Decreases Expression	[38]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Decreases Expression	[38]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Decreases Expression	[38]
Transmembrane 6 superfamily member 1 (TM6SF1)	OTQR4I2N	TM6S1_HUMAN	Increases Expression	[38]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Increases Expression	[38]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Decreases Expression	[38]
Centromere protein H (CENPH)	OTPOO9LK	CENPH_HUMAN	Decreases Expression	[38]
Kinetochore-associated protein DSN1 homolog (DSN1)	OTHROI0H	DSN1_HUMAN	Decreases Expression	[38]
Uncharacterized protein C1orf198 (C1ORF198)	OTK3L4G7	CA198_HUMAN	Increases Expression	[38]
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2)	OTFTH6ZY	GAPR1_HUMAN	Increases Expression	[38]
Very long chain fatty acid elongase 6 (ELOVL6)	OTB26UJJ	ELOV6_HUMAN	Decreases Expression	[38]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Increases Expression	[38]
Gremlin-2 (GREM2)	OTE91EWT	GREM2_HUMAN	Increases Expression	[38]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Increases Expression	[38]
Protein ECT2 (ECT2)	OTQDUCT6	ECT2_HUMAN	Decreases Expression	[38]
Claspin (CLSPN)	OTZZXNDK	CLSPN_HUMAN	Decreases Expression	[38]
Mineralization regulator ANKH (ANKH)	OTCN25R5	ANKH_HUMAN	Increases Expression	[38]
Ribonucleoprotein PTB-binding 2 (RAVER2)	OT0MDL7K	RAVR2_HUMAN	Increases Expression	[38]
Neurexin-3-beta (NRXN3)	OTJ0I7HJ	NRX3B_HUMAN	Increases Expression	[38]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Increases Expression	[38]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[38]
Phospholipid scramblase 4 (PLSCR4)	OT2AMYLY	PLS4_HUMAN	Increases Expression	[38]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[38]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM)	OTALLHT1	FIRRM_HUMAN	Decreases Expression	[38]
Protein diaphanous homolog 3 (DIAPH3)	OTPOT23F	DIAP3_HUMAN	Decreases Expression	[38]
Structural maintenance of chromosomes protein 4 (SMC4)	OTEJE6AG	SMC4_HUMAN	Decreases Expression	[38]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Increases Expression	[38]
Tyrosyl-DNA phosphodiesterase 1 (TDP1)	OTYINMBR	TYDP1_HUMAN	Decreases Expression	[38]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Decreases Expression	[38]
Histone chaperone ASF1B (ASF1B)	OTKXX12I	ASF1B_HUMAN	Decreases Expression	[38]
PCNA-interacting partner (PARPBP)	OTPZDGW7	PARI_HUMAN	Decreases Expression	[38]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[38]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Increases Expression	[38]
Protein Mis18-alpha (MIS18A)	OTD80K5X	MS18A_HUMAN	Decreases Expression	[38]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Decreases Expression	[38]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Decreases Expression	[38]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Increases Expression	[38]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)	OT1PAIN0	CACO1_HUMAN	Increases Expression	[38]
Homologous-pairing protein 2 homolog (PSMC3IP)	OT9UB5UO	HOP2_HUMAN	Decreases Expression	[38]
Fibulin-5 (FBLN5)	OTLVNZ8U	FBLN5_HUMAN	Increases Expression	[38]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)	OTHLNI51	ABC3B_HUMAN	Decreases Expression	[38]
STEAP1 protein (STEAP1)	OTJMW5R9	STEA1_HUMAN	Decreases Expression	[38]
Carboxypeptidase A4 (CPA4)	OT66MP0F	CBPA4_HUMAN	Decreases Expression	[38]
DNA helicase MCM8 (MCM8)	OTC93H3S	MCM8_HUMAN	Decreases Expression	[38]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Decreases Expression	[38]
Angiopoietin-related protein 2 (ANGPTL2)	OTB6JG41	ANGL2_HUMAN	Increases Expression	[38]
Integrin alpha-11 (ITGA11)	OTBWSRA1	ITA11_HUMAN	Increases Expression	[38]
Protein HEG homolog 1 (HEG1)	OT3CUXA7	HEG1_HUMAN	Increases Expression	[38]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[38]
Synaptopodin-2 (SYNPO2)	OTC3U0YH	SYNP2_HUMAN	Increases Expression	[38]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)	OT953SV2	ATS5_HUMAN	Increases Expression	[38]
Protein timeless homolog (TIMELESS)	OTD8DCBJ	TIM_HUMAN	Decreases Expression	[38]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Increases Expression	[38]
Exonuclease 1 (EXO1)	OTI87RS5	EXO1_HUMAN	Decreases Expression	[38]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Increases Expression	[38]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Decreases Expression	[38]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Decreases Expression	[38]
Serine/threonine-protein kinase 38-like (STK38L)	OTI00JVW	ST38L_HUMAN	Increases Expression	[38]
Small kinetochore-associated protein (KNSTRN)	OTYA7UXS	SKAP_HUMAN	Decreases Expression	[38]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Decreases Expression	[38]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Expression	[38]
Carboxypeptidase Q (CPQ)	OTTNZNLD	CBPQ_HUMAN	Increases Expression	[38]
Transforming acidic coiled-coil-containing protein 3 (TACC3)	OTRNEZTA	TACC3_HUMAN	Decreases Expression	[38]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)	OTMRW5U5	IRAG1_HUMAN	Increases Expression	[38]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Decreases Expression	[38]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[46]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS)	OTFBFPV4	ADAS_HUMAN	Increases Expression	[47]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[47]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[47]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Decreases Phosphorylation	[47]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Phosphorylation	[47]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[47]
cAMP-regulated phosphoprotein 19 (ARPP19)	OTZS3IT6	ARP19_HUMAN	Increases Expression	[47]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Increases Expression	[48]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Affects Localization	[49]
Tyrosine-protein kinase ABL1 (ABL1)	OT09YVXH	ABL1_HUMAN	Decreases Activity	[50]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[48]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Activity	[51]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[52]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[52]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Increases Expression	[48]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Decreases Expression	[52]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Activity	[53]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Decreases Expression	[52]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Decreases Expression	[54]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Decreases Activity	[39]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Decreases Phosphorylation	[55]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[52]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Increases Expression	[56]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Activity	[54]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[52]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[57]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Decreases Phosphorylation	[58]
Integrin alpha-M (ITGAM)	OTAG6HWU	ITAM_HUMAN	Increases Expression	[48]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Activity	[50]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Decreases Expression	[52]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Activity	[54]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Decreases Expression	[52]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Decreases Expression	[52]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Decreases Phosphorylation	[59]
C-C motif chemokine 1 (CCL1)	OT23NON8	CCL1_HUMAN	Decreases Expression	[52]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[60]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[39]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[39]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Decreases Expression	[52]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[60]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Decreases Phosphorylation	[58]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Phosphorylation	[61]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Phosphorylation	[57]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[50]
Tyrosine-protein kinase ABL2 (ABL2)	OTS8F4GD	ABL2_HUMAN	Affects Binding	[62]
Crk-like protein (CRKL)	OTOYSD1R	CRKL_HUMAN	Decreases Phosphorylation	[63]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[60]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[52]
Paxillin (PXN)	OTVMMUOF	PAXI_HUMAN	Decreases Phosphorylation	[61]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Cleavage	[39]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[64]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Expression	[52]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[52]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Phosphorylation	[51]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Increases Phosphorylation	[48]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Phosphorylation	[60]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Decreases Expression	[52]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[39]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[39]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[64]
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1)	OTF91GTL	FIP1_HUMAN	Decreases Phosphorylation	[59]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Phosphorylation	[65]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)	OTYRXD2T	PMYT1_HUMAN	Decreases Activity	[66]
Transcription factor SOX-17 (SOX17)	OT9H4WWE	SOX17_HUMAN	Decreases Localization	[67]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Affects Localization	[49]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Increases Response To Substance	[60]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)	OTK3EJFD	NSDHL_HUMAN	Decreases Response To Substance	[68]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Decreases Response To Substance	[68]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DCK80M5	COLO320DM	Investigative	[1]
Adenocarcinoma	DCLXJV2	DLD1	Investigative	[1]
Malignant melanoma	DCUAMO9	A375	Investigative	[1]
Malignant melanoma	DCU06SH	UACC62	Investigative	[1]
Mesothelioma	DCKS62T	MSTO	Investigative	[1]
Ovarian endometrioid adenocarcinoma	DCNIIED	A2780	Investigative	[1]
Ovarian serous cystadenocarcinoma	DCMGHD5	SK-OV-3	Investigative	[1]
Prostate carcinoma	DC71XEL	VCAP	Investigative	[1]
Breast carcinoma	DCTZ56Y	OCUBM	Investigative	[69]
Carcinoma	DCXBHET	OV90	Investigative	[69]
Carcinoma	DCNKI39	MDAMB436	Investigative	[69]
Rectal adenocarcinoma	DCDHJ3P	SW837	Investigative	[69]

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