Details of the Drug Combinations

General Information of This Drug (ID: DMQ2FKJ)

• Drug Name: Teriflunomide (DMQ2FKJ)

Indication

Hyperlipidaemia; ICD 11: 5C80; Status: Approved [1]; Lupus nephritis; ICD 11: 4A40.0Y; Status: Approved [2]; Multiple sclerosis; ICD 11: 8A40; Status: Approved [3]; Psoriatic arthritis; ICD 11: FA21; Status: Approved [2]; Rheumatoid arthritis; ICD 11: FA20; Status: Phase 3 [3]; Hepatitis B virus infection; ICD 11: 1E51.0; Status: Phase 1 [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

59 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Teriflunomide	DCE4TCO	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Amodiaquine + Teriflunomide	DCWYLTX	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
AS-1949490 + Teriflunomide	DCCS77S	AS-1949490	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Asenapine + Teriflunomide	DC95YEL	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Brincidofovir + Teriflunomide	DCMQBST	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Cerivastatin + Teriflunomide	DCALCBC	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Chlorphenesin + Teriflunomide	DC7R5CH	Chlorphenesin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Chlorzoxazone + Teriflunomide	DCGANGZ	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Clopidogrel + Teriflunomide	DCE0095	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Crotamiton + Teriflunomide	DCZ3FMF	Crotamiton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dichlorphenamide + Teriflunomide	DCQ75ZN	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Flavonoid derivative 1 + Teriflunomide	DCSA17I	Flavonoid derivative 1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
IT-141 + Teriflunomide	DCK9OXA	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Loperamide + Teriflunomide	DCVI721	Loperamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mefloquine + Teriflunomide	DCZY87T	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Methotrexate + Teriflunomide	DCXRCZM	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Mitapivat + Teriflunomide	DCRYP69	Mitapivat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Mycophenolic acid + Teriflunomide	DC5E7I8	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pazopanib HCl + Teriflunomide	DC37WFG	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
PHA-739358 + Teriflunomide	DCV7TKZ	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Pyrazinamide + Teriflunomide	DCB5SS3	Pyrazinamide	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + Baclofen	DCA62QC	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Buparlisib	DCENDT8	Buparlisib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + Imipramine	DC2J7ZX	Imipramine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Epinephrine	DC0UOWO	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + MK-1775	DCCJH6Y	MK-1775	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + Anamorelin	DC3O2J5	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Fomepizole	DCD94IQ	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Everolimus	DCDFNLR	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Everolimus	DCEEEJ2	Everolimus	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + LY2835219	DCR1DUW	LY2835219	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + Pepstatin	DCBJI3V	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + 10-hydroxycamptothecin	DCPN6D0	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Selumetinib	DCV0N0Q	Selumetinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + SCH 727965	DCCX49J	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Plinabulin	DC84I2I	Plinabulin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + Daidzin	DCJRHDK	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + VR-776	DCX2MIO	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Triflupromazine	DC0MCS9	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Etonogestrel	DCT1TVU	Etonogestrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Ibutilide	DC7O7TA	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + LEE011	DC8DCYG	LEE011	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + Methylene blue	DCP43UX	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Mebendazole	DC63YRU	Mebendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Artemisinin	DC41BNC	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + BMS-754807	DCIP3M8	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Teriflunomide + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	DCHOZEQ	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Hyodeoxycholic acid	DC536OD	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Mycophenolic acid	DCX3CHG	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Silver sulfadiazine	DCG0DEQ	Silver sulfadiazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Hydroxychloroquine	DCONJH0	Hydroxychloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Albendazole	DCF8T62	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Tetracycline	DC0UV24	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Teriflunomide + Cytarabine	DCR8I5Z	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Tiagabine + Teriflunomide	DCB553J	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Triamterene + Teriflunomide	DCHIJA7	Triamterene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Venglustat + Teriflunomide	DCKC98B	Venglustat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Vinblastine + Teriflunomide	DCVEEEV	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Vorinostat + Teriflunomide	DC2YGUE	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cholestyramine + Teriflunomide	DCROYX3	Cholestyramine	Renal Impairment	[5]
Cholestyramine + Teriflunomide	DCNEQCJ	Cholestyramine	Multiple Sclerosis	[6]
Colestipol + Teriflunomide	DCLCVTQ	Colestipol	Teriflunomide Elimination	[7]
Glatiramer acetate + Teriflunomide	DCI99KB	Glatiramer acetate	Multiple Sclerosis	[8]
Danazol + Teriflunomide	DCQ1YXO	Danazol	Immune Thrombocytopenia	[9]
Dexamethasone + Teriflunomide	DCQSEGR	Dexamethasone	Immune Thrombocytopenia	[10]

References

• [1] Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
• [2] Teriflunomide FDA Label
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6844).
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT01239459) Pharmacokinetic and Tolerability Study of 14 mg Single Dose of Teriflunomide in Subjects With Severe Renal Impairment
• [6] ClinicalTrials.gov (NCT02046629) A Study to Evaluate the Pharmacokinetic Profiles of Single 14 mg Teriflunomide Tablet in Healthy Chinese Volunteers
• [7] ClinicalTrials.gov (NCT02263547) Rapid Elimination Procedure of Teriflunomide With Colestipol Hydrochloride
• [8] ClinicalTrials.gov (NCT00811395) Long Term Safety of Teriflunomide When Added to Interferon-Beta or Glatiramer Acetate in Patients With Multiple Sclerosis
• [9] ClinicalTrials.gov (NCT06176911) The Combination of Teriflunomide and Danazol for Steroid-resistant/Relapse Immune Thrombocytopenia
• [10] ClinicalTrials.gov (NCT06176235) Teriflunomide Plus High-dose Dexamethasone as First-line Treatment in Newly Diagnosed Primary Immune Thrombocytopenia