Details of the Drug Combinations

General Information of This Drug (ID: DMT9K74)

Drug Name
MK-4815   DMT9K74
Synonyms Antimalarial compound (oral), Merck & Co/MMV
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Investigative [1]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

47 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Bifemelane + MK-4815 DCKT16H Bifemelane Hepatoblastoma (Cell Line: HB3) [2]
BREQUINAR + MK-4815 DC6VOBB BREQUINAR DD2 (Cell Line: DD2) [3]
Dihydroergotamine + MK-4815 DCL2CMH Dihydroergotamine Hepatoblastoma (Cell Line: HB3) [3]
Doxepin + MK-4815 DCI9NSZ Doxepin Hepatoblastoma (Cell Line: HB3) [2]
Ivermectin + MK-4815 DCGO26Z Ivermectin DD2 (Cell Line: DD2) [3]
JTC-801 + MK-4815 DCK88JC JTC-801 DD2 (Cell Line: DD2) [3]
Lumefantrine + MK-4815 DCAD8AM Lumefantrine DD2 (Cell Line: DD2) [3]
Lumefantrine + MK-4815 DCTVGE2 Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
MK-4815 + Artemether DC4G84F Artemether DD2 (Cell Line: DD2) [3]
MK-4815 + Dydrogesterone DC6A03K Dydrogesterone DD2 (Cell Line: DD2) [3]
MK-4815 + Thiolactomycin DCGMEL0 Thiolactomycin DD2 (Cell Line: DD2) [3]
MK-4815 + Sarpogrelate DCO8QME Sarpogrelate DD2 (Cell Line: DD2) [3]
MK-4815 + MK-4815 DCNENWO MK-4815 DD2 (Cell Line: DD2) [3]
MK-4815 + Pyronaridine DC1KIOO Pyronaridine DD2 (Cell Line: DD2) [3]
MK-4815 + JTC-801 DCY5HH8 JTC-801 DD2 (Cell Line: DD2) [3]
MK-4815 + Nitisinone DC4WM6F Nitisinone DD2 (Cell Line: DD2) [3]
MK-4815 + Atovaquone DCU9GXV Atovaquone DD2 (Cell Line: DD2) [3]
MK-4815 + Lumefantrine DC8FAPZ Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + SB-612111 DCS4T2R SB-612111 Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + Artemether DC64Y1B Artemether Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + Dydrogesterone DCEQGMU Dydrogesterone Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + Sarpogrelate DCUMQL3 Sarpogrelate Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + Epothilone B DCBD6H5 Epothilone B Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + Omacetaxine mepesuccinate DCEUUIX Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + JTC-801 DCHXCZK JTC-801 Hepatoblastoma (Cell Line: HB3) [2]
MK-4815 + Atovaquone DCYNSFK Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + MK-4815 DCP51LR Nitisinone DD2 (Cell Line: DD2) [3]
Nitisinone + MK-4815 DC1R37L Nitisinone Hepatoblastoma (Cell Line: HB3) [3]
Omacetaxine mepesuccinate + MK-4815 DCC6JKG Omacetaxine mepesuccinate DD2 (Cell Line: DD2) [3]
Omacetaxine mepesuccinate + MK-4815 DCG09SV Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [2]
Proguanil + MK-4815 DC0016S Proguanil Hepatoblastoma (Cell Line: HB3) [3]
Pyrimethamine + MK-4815 DCNJSQH Pyrimethamine DD2 (Cell Line: DD2) [3]
Pyrimethamine + MK-4815 DCPBDWG Pyrimethamine Hepatoblastoma (Cell Line: HB3) [3]
Quinine + MK-4815 DCBS0NK Quinine Hepatoblastoma (Cell Line: HB3) [3]
Ritonavir + MK-4815 DC3MXAG Ritonavir DD2 (Cell Line: DD2) [3]
Ritonavir + MK-4815 DCMUMUW Ritonavir Hepatoblastoma (Cell Line: HB3) [3]
Sarpogrelate + MK-4815 DC6CWYI Sarpogrelate DD2 (Cell Line: DD2) [3]
Sarpogrelate + MK-4815 DC5GAUN Sarpogrelate Hepatoblastoma (Cell Line: HB3) [2]
SB 228357 + MK-4815 DCWQNXU SB 228357 DD2 (Cell Line: DD2) [3]
SB 228357 + MK-4815 DC0JQD2 SB 228357 Hepatoblastoma (Cell Line: HB3) [2]
T-3.5 + MK-4815 DCCCO03 T-3.5 DD2 (Cell Line: DD2) [3]
T-3.5 + MK-4815 DC39677 T-3.5 Hepatoblastoma (Cell Line: HB3) [2]
Thiolactomycin + MK-4815 DCU30NQ Thiolactomycin DD2 (Cell Line: DD2) [3]
Verapamil + MK-4815 DCERZAA Verapamil DD2 (Cell Line: DD2) [2]
Vorinostat + MK-4815 DCTISXK Vorinostat DD2 (Cell Line: DD2) [3]
Vorinostat + MK-4815 DC305TY Vorinostat Hepatoblastoma (Cell Line: HB3) [3]
ZM-447439 + MK-4815 DCUGMA8 ZM-447439 DD2 (Cell Line: DD2) [3]
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⏷ Show the Full List of 47 DrugCom(s)

References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.