Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0MUKQ)

Drug Name
Guanosine-5'-Diphosphate Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
135398619
ChEBI ID
CHEMBL384759
CAS Number
CAS 146-91-8
TTD Drug ID
DM0MUKQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tissue transglutaminase (TG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ZED1227 DMDXEN5 Coeliac disease DA95 Phase 2 [4]
PMID26560530-Compound-13 DMKF26Z N. A. N. A. Patented [5]
PMID26560530-Compound-54 DM2X4R0 N. A. N. A. Patented [5]
Triazole derivative 1 DM9QB2S N. A. N. A. Patented [5]
Acyl piperidine derivative 3 DMIDUB4 N. A. N. A. Patented [5]
PMID26560530-Compound-14 DM52MIK N. A. N. A. Patented [5]
PMID26560530-Compound-1 DMSI7F2 N. A. N. A. Patented [5]
PMID26560530-Compound-3 DM92OT0 N. A. N. A. Patented [5]
PMID26560530-Compound-11 DMZ5UST N. A. N. A. Patented [5]
Chloroacetyl ester derivative 1 DMW4J0P N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Candida Elongation factor 2 (Candi EFT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Adenosine-5-Diphosphoribose DM96LBV Discovery agent N.A. Investigative [2]
Diphthamide DMRWD9M Discovery agent N.A. Investigative [6]
Drug(s) Targeting Ras-related protein Rab-9A (RAB9A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [2]
Drug(s) Targeting Bacterial Celldivision protein FtsZ (Bact ftsZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TXA709 DMZIK8R MRSA infection 1D01.0Y Phase 1 [7]
Phosphomethylphosphonic Acid Guanylate Ester DM4IRU5 Discovery agent N.A. Investigative [2]
5'-Guanosine-Diphosphate-Monothiophosphate DMIARG7 Discovery agent N.A. Investigative [2]
Drug(s) Targeting Plasmodium Elongation factor 1-alpha 1 (Malaria MEF-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ge2270a DMJK7V0 Bacterial infection 1A00-1C4Z Phase 1 [2]
Amythiamicin DM7SHQ1 Discovery agent N.A. Investigative [8]
Drug(s) Targeting Streptococcus Elongation factor G (Stre-coc fusA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fusidic Acid DMWVCF3 Acne vulgaris ED80 Approved [9]
Drug(s) Targeting Bacterial GTP-binding protein YihA (Bact engB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanosine-5'-Triphosphate DMV2OJX Discovery agent N.A. Investigative [2]
Drug(s) Targeting Plasmodium Adenylosuccinate synthetase (Malaria Adss)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [2]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [2]
Diphosphate DMHY30B Discovery agent N.A. Investigative [2]
6-Cl-IMP DMNTDFV Discovery agent N.A. Investigative [10]
(Carboxyhydroxyamino)Ethanoic Acid DMZB0C3 Discovery agent N.A. Investigative [2]
(C8-R)-Hydantocidin 5'-Phosphate DM5WH6R Discovery agent N.A. Investigative [2]
(C8-S)-Hydantocidin 5'-Phosphate DMMH179 Discovery agent N.A. Investigative [2]
6-O-Phosphoryl Inosine Monophosphate DM6YHBR Discovery agent N.A. Investigative [2]
Hydantocidin-5'-Monophosphate DMOTXP1 Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Alpha-(1,6)-fucosyltransferase (FUT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [11]
Quercetin DM3NC4M Obesity 5B81 Approved [12]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [13]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [14]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [17]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [18]
Pyridoxal Phosphate DMO2K0J Malnutrition 5B50-5B71 Approved [3]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [19]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Celldivision protein FtsZ (Bact ftsZ) TT4W1VJ FTSZ_WOLSP Inhibitor [2]
Bacterial GTP-binding protein YihA (Bact engB) TTO3MV6 ENGB_ECOLI Inhibitor [2]
Candida Elongation factor 2 (Candi EFT2) TTCNGJ5 EF2_CANAL Inhibitor [2]
Plasmodium Adenylosuccinate synthetase (Malaria Adss) TTYQ4AE PURA_PLAFA Inhibitor [2]
Plasmodium Elongation factor 1-alpha 1 (Malaria MEF-1) TTG45NU EF1A_PLAFK Inhibitor [2]
Ras-related protein Rab-9A (RAB9A) TT958S6 RAB9A_HUMAN Inhibitor [2]
Streptococcus Elongation factor G (Stre-coc fusA) TT6HP1T EFG_STRZJ Inhibitor [2]
Tissue transglutaminase (TG2) TT2F4OL TGM2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Gene/Protein Processing [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2410).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Chemical modifications of alpha1,6-fucosyltransferase define amino acid residues of catalytic importance. Biochimie. 2003 Mar-Apr;85(3-4):303-10. doi: 10.1016/s0300-9084(03)00074-9.
4 Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease. Cells. 2022 May 17;11(10):1667.
5 Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63.
6 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7 Clinical pipeline report, company report or official report of TAXIS Pharmaceuticals.
8 The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
9 Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65.
10 High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants. Biol Reprod. 1994 Jun;50(6):1403-12.
11 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
12 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
13 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
14 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
15 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
16 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
17 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
18 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
19 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.